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Skin Biology and Diseases Resource-based Center at Mount Sinai

西奈山皮肤生物学和疾病资源中心

基本信息

批准号：
10676779
负责人：
Elena Ezhkova
金额：
$ 84.5万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676779
关键词：
ATAC-seq Acceleration Adoption Advertising Archives Area Award Bioinformatics Biology Biometry CRISPR/Cas technology Candidate Disease Gene Cells ChIP-seq Clinical Collaborations Communication Communication Barriers Communities Complement Consult Consultations Data Data Analyses Dermatology Development Disease Disease model Educational process of instructing Electronic Mail Ensure Environment Epigenetic Process Evaluation Faculty Faculty Recruitment Financial Support Fostering Funding Future Gene Expression Generations Genes Genomics Geography Goals Grant Health Hi-C High School Student Hospitals Human Individual Infrastructure Institution Interdisciplinary Communication Internships Laboratories Leadership Mentors Minority Modeling Molecular Mus National Institute of Arthritis, and Musculoskeletal, and Skin Diseases New York Patients Persons Physicians Population Heterogeneity Positioning Attribute Productivity Reporting Research Research Personnel Resources Sampling Scholars Program Scholarship Scientist Services Skin Small RNA Standardization Structure Study models Technology Testing Therapeutic Training Training Support Translations Universities analysis pipeline combat cost data integration data visualization design exome sequencing genetic analysis genome sequencing human disease improved induced pluripotent stem cell innovation innovative technologies laboratory experience member minority children minority scientist minority student mouse model novel outreach programs racial disparity recruit screening single cell analysis single-cell RNA sequencing skin barrier skin disorder skin organogenesis social media success synergism technology development transcriptome sequencing transcriptomics underserved minority user-friendly virtual web site whole genome

项目摘要

Summary - Overall The overall goal of the Skin Biology Resource-Based Center (SBDRC) at Mount Sinai is to accelerate research in skin biology and diseases and promote its translation to benefit human health. To achieve this, we will harness the technical innovations, high-end infrastructure and computing power available at Mount Sinai to specifically advance and innovate skin research. In parallel we will ensure a vibrant future for skin biology and diseases research by expanding our research community and increasing its diversity. Administrative Core A will provide management, structure and oversight; award User Scholarships to reduce cost barriers to high end technologies; communicate SBDRC programs through a website and social media; organize research talks, seminars and retreats to promote scientific interchange and collaborations; attract new investigators and support development of junior and physician-scientists through Pilot Grants and Individual Mentoring Committees; and improve diversity through Mount Sinai's newly established Laureates Program that facilitates targeted faculty recruitment, and by establishing the SBDRC Sinai Skin Scholars Program, which will introduce underserved East Harlem high school students to skin biology and diseases research. Our Resource Cores are designed to capitalize on Mount Sinai's institutionally-supported and highly innovative technological infrastructure and expertise. We will support effort for technological experts to prioritize SBDRC goals and immerse themselves in skin research labs. Each Resource Core will provide unique expertise from leaders in diverse research areas, and technology, training and services customized to users' needs. The 3 Resource Cores will interact seamlessly: Resource Core B, “Modeling of Skin Disease for Mechanistic Analysis and Therapeutic Discovery,” will facilitate access to human skin samples, and provide technology, consultation and assistance with multiplexed immunostaining, isolation of skin cell subpopulations, generation and analysis of genetic mouse models, and gene editing and gene expression manipulation in human iPSC-derived skin cells. Skin cells or samples from Core B will be analyzed at the molecular level in Resource Core C, “Skin Genomics, Transcriptomics, and Epigenetics Core,” which will provide access to genomics (exome sequencing, whole genome sequencing, and targeted capture), transcriptomics (RNA-seq, ISO-seq, small RNA seq), epigenetic (ATAC-seq, ChIP-seq, CUT&RUN, Hi-C), and single-cell (scRNA-seq, scATAC-seq, spatial transcriptomics) technologies. Resource Core D, “Data Analysis and Integration Core,” will provide standardized biostatistical and bioinformatics analysis and integration of Core C data and make these easily available through Skin-GLOW, a novel user-friendly interface for data visualization. In turn, data analyzed in Core D will yield candidate genes and mechanisms that will be tested through functional analyses provided in Core B. Our plans will create a productive, impactful and extensive skin Research Community including strong external hubs at NYU and at Yale University.

总结-总体西奈山皮肤生物学资源中心（SBDRC）的总体目标是加速研究在皮肤生物学和疾病，并促进其翻译，以造福人类健康。为了实现这一目标，我们将利用西奈山可用的技术创新、高端基础设施和计算能力，特别是先进和创新皮肤研究。与此同时，我们将确保皮肤生物学充满活力的未来，通过扩大我们的研究社区并增加其多样性来进行疾病研究。行政核心A 将提供管理，结构和监督;授予用户奖学金，以减少成本障碍，高端技术;通过网站和社交媒体交流SBDRC计划;组织研究会谈，研讨会和务虚会，以促进科学交流和合作;吸引新的研究人员，通过试点赠款和个人指导支持青年科学家和医生科学家的发展委员会;并通过西奈山新成立的获奖者计划，促进多样性有针对性的教师招聘，并通过建立SBDRC西奈皮肤学者计划，这将介绍东哈莱姆高中的贫困学生皮肤生物学和疾病的研究。我们的资源核心旨在利用西奈山的机构支持和高度创新的技术，基础设施和专业知识。我们将支持技术专家优先考虑SBDRC目标的努力，沉浸在皮肤研究实验室里每个资源核心将提供来自领导者的独特专业知识，多样化的研究领域，以及根据用户需求定制的技术、培训和服务。3资源核心将无缝地相互作用：资源核心B，“皮肤病的机制分析和治疗发现”将促进获得人类皮肤样本，并提供技术，咨询，并协助多重免疫染色、皮肤细胞亚群的分离、生成和分析基因小鼠模型，以及人类iPSC衍生皮肤中的基因编辑和基因表达操作细胞来自核心B的皮肤细胞或样品将在资源核心C“皮肤”中在分子水平上进行分析。基因组学、转录组学和表观遗传学核心”，这将提供对基因组学（外显子组测序、全基因组测序和靶向捕获）、转录组学（RNA-seq、ISO-seq、小 RNA seq）、表观遗传（ATAC-seq、ChIP-seq、CUT&RUN、Hi-C）和单细胞（scRNA-seq、scATAC-seq、空间转录组学）技术。资源核心D“数据分析和集成核心”将提供标准化的生物统计学和生物信息学分析以及Core C数据的整合，并使这些数据更容易可通过Skin-GLOW，一种新颖的用户友好的数据可视化界面。反过来，分析的数据核心D将产生候选基因和机制，这些基因和机制将通过中提供的功能分析进行测试核心B。我们的计划将创建一个富有成效，有影响力和广泛的皮肤研究社区，包括强大的在纽约大学和耶鲁大学的外部中心。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate-to-severe disease.

DOI：
10.1111/exd.14389
发表时间：
2021-11
期刊：
Experimental dermatology
影响因子：
3.6
作者：
Sims JT;Chang CY;Higgs RE;Engle SM;Liu Y;Sissons SE;Rodgers GH;Simpson EL;Silverberg JI;Forman SB;Janes JM;Colvin SC;Guttman-Yassky E
通讯作者：
Guttman-Yassky E

Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing.

DOI：
10.1038/s41467-021-26717-7
发表时间：
2021-11-03
期刊：
Nature communications
影响因子：
16.6
作者：
Chakraborty S;Sampath D;Yu Lin MO;Bilton M;Huang CK;Nai MH;Njah K;Goy PA;Wang CC;Guccione E;Lim CT;Hong W
通讯作者：
Hong W

Toxic epidermal necrolysis-like linear IgA bullous dermatosis after third Moderna COVID-19 vaccine in the setting of oral terbinafine.

DOI：
10.1016/j.jdcr.2022.04.021
发表时间：
2022-06
期刊：
JAAD case reports
影响因子：
0
作者：
Han, Joseph;Russo, Gerardo;Stratman, Scott;Psomadakis, Corinna E;Rigo, Rachel;Owji, Shayan;Luu, Yen;Mubasher, Adnan;Gonzalez, Belen Rubio;Ungar, Jonathan;Harp, Joanna;Magro, Cynthia;Ungar, Benjamin;Lamb, Angela;Gulati, Nicholas
通讯作者：
Gulati, Nicholas

Skin proteomic analysis of immune activation associated with regression of melanoma metastases induced by diphencyprone.

皮肤蛋白质组学分析的免疫激活与辅助链酮诱导的黑色素瘤转移的消退有关。

DOI：
10.1016/j.jdin.2022.08.006
发表时间：
2022-12
期刊：
JAAD international
影响因子：
0
作者：
Han, Joseph;da Rosa, Joel Correa;Owji, Shayan;Yassky, Daniel;Lu, Yen;Estrada, Yeriel;Ungar, Jonathan;Ji, Andrew;Krueger, James G.;Gulati, Nicholas
通讯作者：
Gulati, Nicholas

Integration of Single-Cell Transcriptomics With a High Throughput Functional Screening Assay to Resolve Cell Type, Growth Kinetics, and Stemness Heterogeneity Within the Comma-1D Cell Line.