Yale Cooperative Center of Excellence in Hematology

耶鲁大学血液学卓越合作中心

• 批准号: 10677840
• 负责人: JOHN HWA
• 金额: $ 81.38万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677840
• 关键词: Area; Bioinformatics; Biology; Biomedical Research; Blood Cells; Blood Platelets; Bone Marrow; Cell Communication; Cells; Cellular biology; Collaborations; Core Facility; Country; Development; Disease; Education; Educational process of instructing; Emerging Technologies; Environment; Erythrocyte Transfusion; Faculty; Genomics; Goals; Hematological Disease; Hematology; Hematopoiesis; Hematopoietic stem cells; Image; Inherited; Institution; Leadership; Learning; Medical Informatics; Medical center; Microscopy; Molecular Biology; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Malignant; Performance; Play; Process; Proteins; Proteomics; RNA; Regulation; Research; Research Personnel; Research Support; Resources; Role; Scientist; Signal Transduction; Systems Biology; Techniques; Technology; Training; Training Activity; Training and Education; Universities; base; clinical center; clinical investigation; cost effectiveness; gene function; genome analysis; hematopoietic differentiation; hematopoietic stem cell self-renewal; improved; innovation; interest; medical schools; member; new technology; next generation; novel therapeutic intervention; progenitor; programs; self-renewal; stem cell biology; stem cells; synergism

Abstract The purpose of the Yale Cooperative Center of Excellence in Hematology (YCCEH) is to facilitate and enhance research by investigators engaged in nonmalignant hematology-related research. Our unique focus is the application of emerging technologies to the study of normal and perturbed hematopoiesis. This includes understanding stem cell biology, hematopoiesis, including the processes of self renewal, expansion and differentiation of hematopoietic stem cells, through intermediate progenitor and precursor stages, to mature differentiated and functional blood cells of different lineages. Members of our Research Base are actively engaged in a wide range of topics in the field of hematology, from the stem cell to the bone marrow microenvironment, from understanding mechanisms of hematologic disease to development of novel therapeutic strategies for inherited and acquired disorders, from transfusion of red blood cells and platelets to study of related complications. In parallel, specific technologies utilized across the YCCEH reflect this diversity, with techniques from many fields utilized including cell signaling, genomics, proteomics, RNA biology, molecular biology, advanced imaging and microscopy, to better understand hematologic processes. The resources and environment of the Yale University School of Medicine have been and continue to be particularly well suited to the Center because of the interests and expertise of many of its faculty in the areas of hematology, stem cell biology, genomic analyses and bioinformatics. The availability of a large range of existing core facilities at Yale that directly interface with the YCCEH’s cores, such as the Yale Stem Cell Center, the Yale Center for Genome Analysis, the Yale Center for Clinical Investigation, the Yale Center for Medical Informatics, the Yale Center for High-Performance Computation in Biomedicine, the Yale Systems Biology Institute and the newly established DeLuca Center for Research in Hematology further synergize hematology research across the university. Together, these resources support numerous critical core facilities relevant to hematology investigators. The YCCEH will continue to serve our Research Base (both at Yale and external) by providing training and expertise through the Emerging Technology Research Cores, while providing enhanced opportunities for education and interactions through the Enrichment Core. The Emerging Technology Research Cores will not only enhance research by providing access to cutting edge technologies, but also improve cost-effectiveness of supported research. The long term goal of the YCCEH is to play a key role in the integrated program of hematologic diseases-related research support provided by other NIDDK Cooperative Centers of Excellence in Hematology by providing opportunities to promote increased collaboration within our Research Base and with investigators at other institutions, supporting a broad and deep hematologic diseases research base.

摘要 耶鲁大学血液学卓越合作中心（YCCEH）的目的是促进和 加强从事非恶性血液学相关研究的研究者的研究。我们独特 重点是新兴技术在正常和受干扰造血研究中的应用。这 包括理解干细胞生物学，造血，包括自我更新的过程， 造血干细胞的扩增和分化，通过中间祖细胞和前体 阶段，以使不同谱系的分化和功能性血细胞成熟。我们的研究成员 基地积极从事广泛的主题在血液学领域，从干细胞， 骨髓微环境，从了解血液病的机制到发展 遗传性和获得性疾病的新治疗策略，从输注红细胞， 血小板相关并发症的研究。与此同时，整个YCCEH使用的特定技术 反映了这种多样性，利用了许多领域的技术，包括细胞信号传导，基因组学， 蛋白质组学，RNA生物学，分子生物学，先进的成像和显微镜，以更好地了解 血液学过程耶鲁大学医学院的资源和环境， 一直并将继续特别适合该中心，因为利益和专业知识， 其许多教师从事血液学、干细胞生物学、基因组分析和生物信息学领域的工作。 耶鲁现有的大量核心设施的可用性，直接与YCCEH的接口， 核心，如耶鲁干细胞中心，耶鲁基因组分析中心，耶鲁基因组研究中心， 临床研究，耶鲁大学医学信息学中心，耶鲁大学高性能研究中心 生物医学计算，耶鲁系统生物学研究所和新成立的DeLuca中心 在血液学研究进一步协同血液学研究在整个大学。所有这些 资源支持与血液学研究者相关的许多关键核心设施。青年会将 通过提供培训和专业知识，继续为我们的研究基地（包括耶鲁大学和外部）服务 通过新兴技术研究核心，同时提供更多的教育机会 以及通过浓缩核心的互动新兴技术研究核心不仅将 通过提供尖端技术来加强研究，同时提高成本效益 支持的研究。青年中心的长期目标是在以下综合方案中发挥关键作用： 其他NIDDK合作中心提供的血液病相关研究支持， 通过提供机会促进我们内部的合作， 研究基地和其他机构的研究人员，支持广泛而深入的血液学研究。 疾病研究基地。

项目成果

Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis.

• DOI: 10.1038/s12276-022-00770-8
• 发表时间: 2022-05
• 期刊: EXPERIMENTAL AND MOLECULAR MEDICINE
• 影响因子: 12.8
• 作者: Di Pietro, Caterina;Oz, Hasan H.;Zhang, Ping-xia;Cheng, Ee-chun;Martis, Valentino;Bonfield, Tracey L.;Kelley, Thomas J.;Jubin, Ronald;Abuchowski, Abraham;Krause, Diane S.;Egan, Marie E.;Murray, Thomas S.;Bruscia, Emanuela M.
• 通讯作者: Bruscia, Emanuela M.

Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.

• DOI: 10.1016/j.molcel.2022.02.025
• 发表时间: 2022-03-17
• 期刊: Molecular cell
• 影响因子: 16
• 作者: Biancon G;Joshi P;Zimmer JT;Hunck T;Gao Y;Lessard MD;Courchaine E;Barentine AES;Machyna M;Botti V;Qin A;Gbyli R;Patel A;Song Y;Kiefer L;Viero G;Neuenkirchen N;Lin H;Bewersdorf J;Simon MD;Neugebauer KM;Tebaldi T;Halene S
• 通讯作者: Halene S

Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction.

• DOI: 10.1101/gr.276578.122
• 发表时间: 2022-09-27
• 期刊: GENOME RESEARCH
• 影响因子: 7
• 作者: Griffin, Kimberly N.;Walters, Benjamin William;Li, Haixin;Wang, Huafeng;Biancon, Giulia;Tebaldi, Toma;Kaya, Carolyn B.;Kanyo, Jean;Lam, TuKiet T.;Cox, Andy L.;Halene, Stephanie;Chung, Jean-Ju;Lesch, Bluma J.
• 通讯作者: Lesch, Bluma J.

Spatial confinement downsizes the inflammatory response of macrophages.

• DOI: 10.1038/s41563-018-0190-6
• 发表时间: 2018-12
• 期刊: Nature materials
• 影响因子: 41.2
• 作者: Jain N;Vogel V
• 通讯作者: Vogel V

High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue.

• DOI: 10.1016/j.cell.2020.10.026
• 发表时间: 2020-12-10
• 期刊: Cell
• 影响因子: 64.5
• 作者: Liu Y;Yang M;Deng Y;Su G;Enninful A;Guo CC;Tebaldi T;Zhang D;Kim D;Bai Z;Norris E;Pan A;Li J;Xiao Y;Halene S;Fan R
• 通讯作者: Fan R