TRP channel regulation of feeding behavior in Drosophila

TRP 通道对果蝇摄食行为的调节

基本信息

  • 批准号:
    10641098
  • 负责人:
  • 金额:
    $ 22.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-24 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY: TRP channel regulation of feeding behavior in Drosophila Feeding is one of the most fundamental of all animal behaviors. In mammals, diverse signals, including chemosensory responses to food properties and mechanical stimulation of the gut, regulate satiation and feeding behavior. These mechanisms, or analogous systems, are well-conserved in invertebrates. Although many neuropeptides and neurotransmitters have been identified that signal satiation or satiety, much less is known about how gut stretch and other mechanosensory forces are signaled to regulate feeding behavior. Due to the remarkable conservation in their basic physiological and neurological properties, studies in Drosophila have revolutionized our broad understanding of animal behavior. Despite the successful use of flies in investigating paradigms such as sleep, circadian rhythm, and memory, only recently have tools for measuring fly food intake facilitated the study of feeding behavior. This project will use Drosophila melanogaster to investigate the regulation of meal intake. New methods allow undisturbed real-time measurements of food consumption in freely behaving adult flies that resolve with unrivalled accuracy the effects of diet and hunger on meal size. An experimental framework is established for defining fly meals and to show their basic regulation by manipulation of the diet, internal hunger state, and circadian rhythms. Using the powerful genetic tools available in Drosophila, preliminary results reveal the involvement of transient receptor potential (TRP) channels in the regulation of meal intake. TRP channels define a large family of sensory receptors, and much is still unknown about how they function as chemo-, mechano-, and other types of receptors. The proposed studies will dissect the role of TRP channel signaling in satiation and meal size control, taking advantage of the tools available in the simplified Drosophila model. Given the increasing importance of meal intake and patterning on physiology and health—regardless of total caloric intake—the proposed studies have the potential to reveal key insights on the role of TRP channel signaling on regulating prandial behavior, physiology, and metabolism. The proposed studies may also eventually inform the design of pesticides targeting TRP channels or feeding behavior in other insects, including agricultural pests and disease vectors such as mosquitos.
项目概述:TRP通道对果蝇摄食行为的调控

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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WILLIAM W JA其他文献

WILLIAM W JA的其他文献

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{{ truncateString('WILLIAM W JA', 18)}}的其他基金

TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
  • 批准号:
    10683242
  • 财政年份:
    2021
  • 资助金额:
    $ 22.11万
  • 项目类别:
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
  • 批准号:
    10494137
  • 财政年份:
    2021
  • 资助金额:
    $ 22.11万
  • 项目类别:
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
  • 批准号:
    10344523
  • 财政年份:
    2021
  • 资助金额:
    $ 22.11万
  • 项目类别:
Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila
果蝇代谢和衰老的营养和表观遗传启动
  • 批准号:
    8840866
  • 财政年份:
    2014
  • 资助金额:
    $ 22.11万
  • 项目类别:
Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila
果蝇代谢和衰老的营养和表观遗传启动
  • 批准号:
    8696160
  • 财政年份:
    2014
  • 资助金额:
    $ 22.11万
  • 项目类别:
Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila
果蝇代谢和衰老的营养和表观遗传启动
  • 批准号:
    9060847
  • 财政年份:
    2014
  • 资助金额:
    $ 22.11万
  • 项目类别:
Drosophila feeding behavior: New tools for the genetic dissection of prandiology
果蝇摄食行为:prandiology 基因剖析的新工具
  • 批准号:
    8318102
  • 财政年份:
    2011
  • 资助金额:
    $ 22.11万
  • 项目类别:
Drosophila feeding behavior: New tools for the genetic dissection of prandiology
果蝇摄食行为:prandiology 基因剖析的新工具
  • 批准号:
    8164958
  • 财政年份:
    2011
  • 资助金额:
    $ 22.11万
  • 项目类别:
Role of bacteria in development and lifespan of Drosophila melanogaster
细菌在果蝇发育和寿命中的作用
  • 批准号:
    8010996
  • 财政年份:
    2010
  • 资助金额:
    $ 22.11万
  • 项目类别:
Role of bacteria in development and lifespan of Drosophila melanogaster
细菌在果蝇发育和寿命中的作用
  • 批准号:
    8233401
  • 财政年份:
    2010
  • 资助金额:
    $ 22.11万
  • 项目类别:

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相似海外基金

TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
  • 批准号:
    10683242
  • 财政年份:
    2021
  • 资助金额:
    $ 22.11万
  • 项目类别:
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
  • 批准号:
    10494137
  • 财政年份:
    2021
  • 资助金额:
    $ 22.11万
  • 项目类别:
TRP channel regulation of feeding behavior in Drosophila
TRP 通道对果蝇摄食行为的调节
  • 批准号:
    10344523
  • 财政年份:
    2021
  • 资助金额:
    $ 22.11万
  • 项目类别:
Hyaluronan-TRP channel regulation in the induction of apoptosis in cancer spheroids
透明质酸-TRP通道调节诱导癌球体细胞凋亡
  • 批准号:
    20K06437
  • 财政年份:
    2020
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TRP-CHANNELS IN LENS DEVELOPMENT AND CATARACT
TRP 通道在晶状体发育和白内障中的作用
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TRP-CHANNELS IN LENS DEVELOPMENT AND CATARACT
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    2019
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    $ 22.11万
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  • 批准号:
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