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Imaging Structure and Function of Photoreceptors

感光器的成像结构和功能

基本信息

批准号：
10683343
负责人：
Donald T Miller
金额：
$ 56.03万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683343
关键词：
3-Dimensional Affect Algorithms Anatomy Blindness Cells Clinic Color Color Visions Complex Cone Custom Data Detection Disease Early Diagnosis Early treatment Electrophysiology (science)Electroretinography Eye Genotype Goals Grant Human Image Individual Inherited Investigation Laboratories Length Light Measurement Measures Mediating Methods Modality Monitor Optical Coherence Tomography Optical Methods Optics Outcome Patients Phase Phenotype Photoreceptors Physiological Physiological Processes Process Process Assessment Property Psychophysics Red-Green Color Blindness Research Resolution Retina Retinal Cone Retinal Degeneration Retinitis Pigmentosa Safety Specificity Structure System Techniques Technology Testing Tissues Vision X Inactivation adaptive optics cell type gene replacement therapy genetic testing image registration improved in vivo instrumentation light scattering live cell imaging mosaic neural neuroprotection response retinal rods stem cell therapy therapy development tool treatment trial

项目摘要

Project Summary/Abstract Human vision starts when photoreceptors collect and respond to light. Normal photoreceptor function is essential for normal vision, yet techniques to assess these processes in vivo are limited. New optical modalities that are rapid, specific, and non‐invasive promise to greatly expand our capability to monitor more accurately and completely photoreceptors. This study takes advantage of unique adaptive‐optics OCT instrumentation developed in my laboratory in conjunction with custom algorithms for sub‐cellular image registration and phase‐sensitive detection to measure anatomical and physiological properties of individual photoreceptors. We will use this technique to investigate three specific aims that quantify the spectral sensitivity profiles of photoreceptors, the expression of photoreceptor spectral types in color vision deficiencies, and the temporal dynamics of photoreceptor loss in retinitis pigmentosa patients. The long term goal of this research is to establish high resolution, high specificity optical techniques as valid tools for probing structure and physiologic processes of the retina at the cellular scale. The resulting ability to study cells in vivo will improve early detection of and treatment monitoring for diseases that impact the retina.

项目概要/摘要当光感受器收集光并对光做出反应时，人类的视觉就开始了。正常的感光功能是对于正常视力至关重要，但体内评估这些过程的技术有限。新的光学模式快速、具体且非侵入性的承诺将大大扩展我们更准确监测的能力和完全的光感受器。这项研究利用了我的实验室开发的独特的自适应光学 OCT 仪器与亚细胞图像配准和相敏检测的定制算法相结合测量单个光感受器的解剖学和生理学特性。我们将使用这项技术来研究量化光感受器光谱灵敏度分布的三个具体目标，色觉缺陷中的感光器光谱类型，以及色觉缺陷中感光器损失的时间动态色素性视网膜炎患者。本研究的长期目标是建立高分辨率、高特异性光学技术作为探测细胞视网膜结构和生理过程的有效工具规模。由此产生的体内细胞研究能力将改善以下疾病的早期检测和治疗监测：影响视网膜的疾病。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction.

DOI：
10.1364/oe.16.008126
发表时间：
2008-05
期刊：
Optics express
影响因子：
3.8
作者：
R. Zawadzki;B. Cense;Yan Zhang;Stacey S. Choi;Donald T. Miller;J. Werner
通讯作者：
R. Zawadzki;B. Cense;Yan Zhang;Stacey S. Choi;Donald T. Miller;J. Werner

Adaptive optics and the eye (super resolution OCT).

自适应光学和眼睛（超级分辨率OCT）。

DOI：
10.1038/eye.2011.1
发表时间：
2011-03
期刊：
EYE
影响因子：
3.9
作者：
Miller, D. T.;Kocaoglu, O. P.;Wang, Q.;Lee, S.
通讯作者：
Lee, S.

Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography.

DOI：
10.1073/pnas.2107444118
发表时间：
2021-11-23
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Lassoued A;Zhang F;Kurokawa K;Liu Y;Bernucci MT;Crowell JA;Miller DT
通讯作者：
Miller DT

Imaging and quantifying ganglion cells and other transparent neurons in the living human retina.

DOI：
10.1073/pnas.1711734114
发表时间：
2017-11-28
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Liu Z;Kurokawa K;Zhang F;Lee JJ;Miller DT
通讯作者：
Miller DT

Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics.