Advancing Cancer Research Through Next Generation Sequencing at Mays Cancer Center of UT Health San Antonio

圣安东尼奥 UT Health 梅斯癌症中心通过下一代测序推进癌症研究

• 批准号: 10684795
• 负责人: Zhao Lai
• 金额: $ 19.14万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684795
• 关键词: Advanced Malignant Neoplasm; Area; Award; Biological Assay; Cancer Center; Cancer Center Support Grant; Caring; Catchment Area; Collaborations; Communities; Core Facility; Development; Education; Environment; Experimental Designs; Funding; Genomics; Grant; Health; High-Throughput Nucleotide Sequencing; Hispanic Populations; Infrastructure; Journals; Knowledge; Leadership; Letters; Malignant Childhood Neoplasm; Malignant Neoplasms; Methodology; Mission; NCI Center for Cancer Research; Peer Review; Procedures; Protocols documentation; Publications; Qualifying; Research; Research Personnel; Research Project Grants; Research Project Summaries; Resource Sharing; Scientist; Secure; Services; Specialist; Strategic Planning; Technology; Technology Assessment; Texas; Training; United States National Institutes of Health; Universities; anticancer research; cancer genome; cancer genomics; career development; improved; innovation; instrumentation; member; next generation sequencing; programs; recruit; skills; success; technology validation

Project Summary This Research Specialist (Core-based Scientist) R50 application seeks support for Dr. Zhao Lai, Director of the Next-Generation Sequencing Shared Resource (NGSSR) in the NCI-designated Mays Cancer Center (MCC; Ruben Mesa, PI) at the University of Texas Health San Antonio (UTHSA). Next-generation sequencing (NGS) is one of the most significant technological advances in cancer genome research. Dr. Lai’s mission through the NGSSR is to provide the cutting-edge genomics technology to the cancer community of MCC. The NGSSR began in 2011 as a core facility with a focus on genomics of pediatric cancer research. Dr. Lai was recruited as a highly qualified genomics scientist to lead the NGS facility. In 2014, the core was integrated into the Cancer Center Support Grant (CCSG) as a Shared Resource. As the NGSSR Director since its inception, Dr. Lai has guided the development of every aspect of this highly regarded Shared Resource (scored “Outstanding” in the successful CCSG renewal in 2020). She has developed and executed strategic plans for technology assessment and implementation, trained and supervised staff scientists, and created all standard operating procedures. Dr. Lai has secured two NIH S10 Shared Instrumentation grants to significantly enhance the genomic infrastructure at UTHSA, continuously established new protocols to expand NGS services to support diverse cancer research applications. She continues to assist investigators NGS projects ranging from experimental design through subsequent interpretation of experimental results, and establishes the extensive collaboration to develop integrative assays and customized protocols that contribute to the long-term success of the MCC’s research program. Under her scientific leadership, the NGSSR has quickly become an essential component in the MCC and fundamentally transformed the genomics research environment for its members. Since 2011, the NGSSR’s Cancer Center users have nearly quadrupled. Currently, the NGSSR supports >42 Cancer Center members and 18 NCI-funded research projects. Dr. Lai’s knowledge of NGS technology and her key intellectual contribution to NGS applications in many NCI-funded research projects have been widely recognized (see Letters of Support), with the NGSSR’s contributions to over 100 publications, many in high-impact peer-reviewed journals. This proposed R50 award will provide a more stable financial basis for the NGS facility, further concentrate Dr. Lai’s efforts on cancer-oriented methodology development, application innovation, and service improvement, and offer her more opportunities in career development in cancer genomics. This award will also allow the NGSSR to continue providing cutting-edge sequencing technology, services, education, and training to MCC cancer research community to provide better care for the unique Hispanic population in our catchment area.

项目摘要 本研究专家（核心科学家）R50申请寻求对赵来博士的支持，赵来博士是 下一代测序共享资源（NGSSR）在美国国家癌症研究所指定的梅斯癌症中心（MCC; Ruben梅萨，PI）在德克萨斯大学健康圣安东尼奥（UTHSA）。下一代测序（NGS） 是癌症基因组研究中最重要的技术进步之一。黎博士的使命， NGSSR是为MCC的癌症社区提供最前沿的基因组学技术。NGSSR 成立于2011年，作为一个核心设施，专注于儿科癌症研究的基因组学。黎博士受聘为 一位高素质的基因组科学家来领导国家地质调查局的设施。2014年，核心被整合到巨蟹座 中心支持补助金（CCSG）作为共享资源。自NGSSR成立以来，黎博士一直担任NGSSR主任， 指导了这一备受推崇的共享资源的各个方面的开发（在 2020年CCSG成功续约）。她制定并执行了技术评估战略计划 科学家培训和监督工作人员，并制定了所有标准作业程序。博士 Lai获得了两项NIH S10共享仪器赠款，以显着增强基因组基础设施 在UTHSA，不断建立新的协议，以扩大NGS服务，以支持各种癌症研究 应用.她继续协助研究人员NGS项目，从实验设计到 随后的实验结果的解释，并建立了广泛的合作，以发展 有助于MCC研究长期成功的综合分析和定制方案 程序.在她的科学领导下，NGSSR已迅速成为MCC的重要组成部分 并从根本上改变了其成员的基因组学研究环境。自2011年以来， 癌症中心的用户几乎翻了两番。目前，NGSSR支持超过42个癌症中心成员， 18个国家癌症研究所资助的研究项目。赖博士对NGS技术的了解以及她对 NGS在许多国家癌症研究所资助的研究项目中的应用得到了广泛的认可（见支持信）， NGSSR为100多篇出版物做出了贡献，其中许多是高影响力的同行评审期刊。这 拟议的R50奖励将为NGS设施提供更稳定的财务基础，进一步集中黎博士的 致力于癌症导向的方法学开发、应用创新和服务改进，并提供 她在癌症基因组学方面有更多的职业发展机会。该奖项还将使NGSSR能够 继续为MCC癌症提供尖端的测序技术、服务、教育和培训 研究社区，以提供更好的照顾独特的西班牙裔人口在我们的集水区。

项目成果

Prevalence of genotoxic bacteria in men undergoing biopsy for prostate cancer.

• DOI: 10.1002/pros.24500
• 发表时间: 2023-05
• 期刊: PROSTATE
• 影响因子: 2.8
• 作者: Lee, John;Wickes, Brian L.;Fu, Jianmin;Brockman, Nohelli E.;Garg, Harshit;Jobin, Christian;Johson-Pais, Teresa;Leach, Robin;Lai, Zhao;Liss, Michael A.
• 通讯作者: Liss, Michael A.