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Cell and Tissue Microscopy Core

细胞和组织显微镜核心

基本信息

批准号：
10686085
负责人：
JYOTI K JAISWAL
金额：
$ 11.9万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686085
关键词：
3-Dimensional Area Bioinformatics Biomedical Engineering Brain Brain Mapping Cell Communication Cells Cellular Structures Child Childhood Collaborations Color Computer software Conceptions Confocal Microscopy Data Data Analyses Dedications Defect Development Disease District of Columbia Doctor of Philosophy Educational workshop Electron Microscopy Electrons Embryo Ensure Equipment Farm Functional Imaging Funding Genetic Genetic Diseases Genomics Goals Hospitals Image Imaging Device In Situ Individual Injury Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Ions Laboratories Light Maps Metabolic Microscope Microscopic Microscopy Mission Molecular Abnormality Monitor Neonatal Brain Injury Neurodevelopmental Disorder Noise Optics Organ Organism Phenotype Postdoctoral Fellow Process Quality Control Research Research Personnel Research Support Resolution Scanning Scanning Electron Microscopy Services Signal Transduction Structural defect Structure Techniques Technology Tissues Training Training Programs United States National Institutes of Health Universities Validation Visualization Washington Work analytical tool animal imaging clinical translation cost effective design digital pathology experience fetal brain injury human imaging image visualization imaging approach imaging platform in vivo in vivo imaging industry partner innovation instrument instrumentation investigator training light microscopy loss of function microscopic imaging multi-photon multiphoton microscopy nanoscale neural circuit neural network neurobehavioral neuroregulation new technology next generation optogenetics quantitative imaging recruit research study structural imaging superresolution imaging superresolution microscopy symposium technology development temporal measurement three-dimensional visualization tissue fixing tool ultra high resolution

项目摘要

ABSTRACT The Cell and Tissue Microscopy Core (CTMC) will support the DC-IDDRC researchers in their work that relies on the use of high-resolution optical and electron microscopic approaches to study cells and tissues. CTMC will offer access to state-of-the-art microscopy imaging and analytical tools to support research focused on pediatric diseases with an emphasis on neurodevelopmental disorders, fetal and neonatal brain injury and genetic diseases. CTMC will extend its services to researchers at Children’s National Hospital, George Washington University, Georgetown University and Howard University. Among these users, there is a growing need for tools that enable imaging at greater spatial and temporal resolution while also allowing functional imaging and deep as well as large area imaging. To support these needs CTMC continues to expand its services including widefield, confocal, live and multiphoton microscopy with optogenetic manipulation, light sheet microscopy, super resolution, correlative light and EM as well as large field 3D-EM. With these developments the core will continue to meet and also expand its mission to enable structural and functional imaging from nanoscale to organismal scale that are aimed at understanding and treating defects leading to IDDs. The core will also help develop and implement quantitative analytical approaches for image visualization and data analysis. The core will also participate in collaborative IDD-relevant projects that heavily rely on the use of newer technologies. A significant mission of the core will be to train next generation of researchers in the use of advanced microscopy approaches through offering hands on training, educational workshops organized by the core in collaboration with other companies and researches in the greater DC region. CTMC will also collaborate with other DC-IDDRC cores including the Human and Animal Imaging Core, Neurobehavioral Core and Genomics and Bioinformatics Core to serve projects with cross disciplinary needs. Through above endeavors CTMC aims to continue leveraging technological developments in microscopy to enable conception, design, and implementation of these developments to tackle challenges in the field of IDD research and further the mission of DC-IDDRC.

摘要细胞和组织显微镜核心（CTMC）将支持DC-IDDRC研究人员的工作，使用高分辨率光学和电子显微镜方法研究细胞和组织。CTMC 将提供最先进的显微成像和分析工具，以支持研究重点是儿科疾病，重点是神经发育障碍、胎儿和新生儿脑损伤，遗传病CTMC将把服务范围扩大到乔治国立儿童医院的研究人员华盛顿大学、乔治敦大学和霍华德大学。在这些用户中，需要能够以更高的空间和时间分辨率成像的工具，同时还允许功能成像和深度以及大面积成像。为了满足这些需求，CTMC继续扩大其服务包括宽视野、共聚焦、活体和多光子显微镜与光遗传学操作、光薄片显微镜、超分辨、相关光和EM以及大视场3D-EM。与这些发展的核心将继续满足，并扩大其使命，使结构和功能从纳米级到生物尺度的成像，旨在了解和治疗导致 IDDs.该核心还将帮助开发和实施图像可视化的定量分析方法和数据分析。核心小组还将参加与缺碘症有关的合作项目，这些项目严重依赖使用较新的技术。核心的一个重要使命将是培养下一代研究人员，使用先进的显微镜方法，通过提供动手培训，教育讲习班，由核心与大华盛顿地区的其他公司和研究机构合作组织。CTMC 还将与其他DC-IDDRC核心合作，包括人类和动物成像核心，神经行为核心和基因组学和生物信息学核心，以服务于具有跨学科需求的项目。通过上述努力，CTMC旨在继续利用显微镜技术的发展，使这些发展的概念、设计和实施能够应对缺碘症领域的挑战研究和推进DC-IDDRC的使命。