RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGY

项目概要/摘要 PREMIER，UCSF 风湿病精准医学中心 (P30)，提供了至关重要的 资源和专业知识，使尖端研究能够推进风湿病的精准医学 疾病。 PREMIER 汇集了临床专业知识、明确的患者群体、最先进的技术 生物信息学和综合分析专家的免疫表型分析和基因组技术。这个 基础设施促进协作研究，可以整合大量临床和分子数据 需要对驱动临床表型异质性的生物学有更基本的了解 以及风湿病患者的治疗反应。总理寻求降低壁垒 通过提供相关资源以及使用这些资源的专业知识来进行风湿病学研究 适当地。 我们的中心包括三个资源核心，每个资源核心将提供咨询以指导研究人员进行研究 设计、分析以及获得重要的专业知识和帮助来形成所需的合作。的 临床数据和信息学核心 (CDI)，由 Jinoos Yazdany 博士领导，将提供临床研究和 信息学服务，包括访问大型风湿病数据库、生物样本和管理 用于研究发现的电子健康记录数据；基因组技术核心（GT），由博士共同指导。 Jimmie Ye 和 Walter Eckalbar 将开发新型基因组技术并建立专门的工作流程 以及为研究风湿病而设计的分析途径；和综合生物信息学核心 （IB），由博士共同指导。 Marina Sirota 和 Gabriela Fragiadakis 将满足研究者对高级技术的需求 生物信息学专业知识，特别是在单细胞分析、多组学综合分析和使用方面 的公开数据。 PREMIER 的行政核心由 Mary Nakamura 博士（主任）和 Dr. Jinoos Yazdany（副主任）为该中心提供领导和组织监督。的 核心包括一个重要的丰富项目，包括研讨会、年度研讨会、由 资源核心、指导计划和拨款计划，包括开发和可行性试点拨款 和核心使用补助金。 PREMIER 利用了 UCSF 和部门的大量重要资源 与 PREMIER 资源核心提供的服务高度协同。 鉴于我们的业绩记录和对创新的坚定承诺，PREMIER 已准备好吸引新的 研究人员并进一步推进风湿病学研究，以实现改善的最终目标 通过详细阐明基础疾病来诊断和治疗风湿性疾病 机制。

PROJECT SUMMARY/ABSTRACT PREMIER, the UCSF Precision Medicine in Rheumatology Center (P30), provides critically important resources and expertise to enable cutting-edge research to advance precision medicine in the rheumatic diseases. PREMIER brings together clinical expertise, defined patient cohorts, state-of-the-art immunophenotyping and genomic technologies with experts in bioinformatics and integrative analyses. This infrastructure facilitates collaborative studies that can integrate the large amounts of clinical and molecular data needed to gain a more fundamental understanding of the biology driving the heterogeneity of clinical phenotypes and treatment responses among individuals with rheumatic disease. PREMIER seeks to lower the barriers to pursuing rheumatology research by providing access to relevant resources along with the expertise to use them appropriately. Our Center includes three Resource Cores that will each provide consultation to guide investigators in study design, analysis, and access to significant expertise and assistance in forming the collaborations needed. The Clinical Data and Informatics Core (CDI), directed by Dr. Jinoos Yazdany, will provide clinical research and informatics services including access to large rheumatic diseases databases, biospecimens and curation of electronic health record data for research discovery; the Genomic Technology Core (GT), co-directed by Drs. Jimmie Ye and Walter Eckalbar, will develop novel genomic technologies and institute specialized workflows and analytic pathways designed for the study of rheumatic diseases; and the Integrative Bioinformatics Core (IB), co-directed by Drs. Marina Sirota and Gabriela Fragiadakis, will address investigator needs for advanced bioinformatics expertise, particularly with regard to single cell analytics, multi-omic integrative analysis, and use of publicly available data. PREMIER’s Administrative Core is led by Dr. Mary Nakamura (Director) and Dr. Jinoos Yazdany (Associate Director) and provides leadership and organizational oversight to the Center. The Core includes a significant enrichment program involving seminars, an annual symposium, workshops led by the Resource Cores, a mentoring program, and a grant program including Development and Feasibility Pilot grants and Core Usage Grants. PREMIER leverages a number of significant UCSF and divisional resources that are highly synergistic with the services offered in PREMIER Resource Cores. Given our track record and deep commitment to innovation, PREMIER is poised to attract new investigators and further advance rheumatology research towards the ultimate goal of improving diagnosis and treatment of rheumatic disease through the detailed elucidation of underlying disease mechanisms.