Pilot Projects

试点项目

• 批准号: 8410353
• 负责人: FULTON T CREWS
• 金额: $ 6.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-10 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8410353
• 关键词: Alcohol consumption; Alcoholic Hepatitis; Alcoholism; Attenuated; Award; Brain; Clinical; Clinical Research; Data; Ethanol; Faculty; Feasibility Studies; Funding; Goals; Grant; Growth; Growth and Development function; Interleukin-1; Interleukin-13; Investigation; Lead; Liver; Mediating; Molecular; Mus; Pathogenesis; Patients; Pilot Projects; Process; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Science; Scientist; Severity of illness; Small Interfering RNA; Testing; Translational Research; Translations; United States National Institutes of Health; alcohol research; alcoholism therapy; base; binge drinking; design; drinking; innovation; liver inflammation; liver injury; programs; receptor; success; translational study

The Pilot Project program is designed to promote alcohol research across the UNC campus. We provide funds to new investigators without current or past research support and to established investigators who propose projects that represent a significant departure from their ongoing research. The goal of the program is to provide sufficient funds to generate pilot data on alcohol research projects that can be used to support applications for research grants. A detailed review process includes Internal solicitation for proposals, involvement and advice from appropriate Center faculty, as well as internal and external review to select studies of the highest quality. The pilot program also takes advantage of funds from the NC Clinical and Translational Research Consortium (NIH Clinical Translation, Science Award) that will match funding by the ARC to outstanding proposals. Previous pilot projects funded by our Center grant have led to new NIH funding for UNC researchers. This process brings new people and new ideas into the center, renewing Its vibrance and innovation and helping to keep us on the forefront of the field. This ARC includes two Pilot Projects (Project 16 and 17) as part of this proposal. Both projects integrate nicely with our theme of ALCOHOL PATHOGENESIS. Project 16 (Ramon Bataller, PI) will test whether p90RSK mediates liver injury and inflammation in alcoholic hepatitis (AH). His group will conduct a translational study with liver samples from patients, where p90RSK expression and activation will be determined and correlated with disease severity. Next, they will investigate whether p90RSK inhibition in mice with experimental AH attenuates liver Injury and inflammation. Project 17 (Donald Lysle, PI) will examine the role of interteukin-1|3 (IL-1 (3) In ethanol binge drinking. His group will test the hypotheses that repeated binge-like drinking increases IL-1 (3 expression in brain and that blocking 1L-1(3 using small interfering RNA (siRNA) or IL-13 receptor antagonist will protect against binge-like ethanol drinking. These Pilot Projects will provide the resources for new investigators to develop preliminary findings important for success In larger research grants. This effort supports the long term growth and success of our ARC.

试点项目旨在促进整个北卡罗来纳大学校园内的酒精研究。我们向没有当前或过去研究支持的新调查人员以及提出与正在进行的研究有重大偏离的项目的老牌调查人员提供资金。该计划的目标是提供足够的资金，以产生酒精研究项目的试点数据，这些数据可用于支持研究拨款的申请。详细的评审过程包括内部征求建议书、适当中心教职员工的参与和建议，以及内部和外部评审以选择最高质量的研究。该试点计划还利用了北卡罗来纳州临床和翻译研究联盟(NIH临床翻译，科学奖)的资金，该联盟将把ARC的资金与未完成的提案相匹配。之前由我们的中心拨款资助的试点项目已经为北卡罗来纳大学的研究人员带来了新的NIH资金。这一过程将新人和新想法带入中心，重新焕发了它的活力和创新能力，并帮助我们保持在该领域的前沿。ARC包括两个试点项目(项目16和项目17)，作为该提案的一部分。这两个项目都与我们的酒精发病机制主题很好地结合在一起。项目16(Ramon Bataller，PI)将测试p90RSK是否介导酒精性肝炎(AH)的肝脏损伤和炎症。他的团队将对患者的肝脏样本进行一项翻译研究，其中p90RSK的表达和激活将被确定并与疾病严重程度相关。接下来，他们将研究抑制实验性急性肝炎小鼠的p90RSK是否可以减轻肝脏损伤和炎症。项目17(Donald Lysle，PI)将研究白细胞介素1|3(IL-1(3))在酗酒中的作用。他的团队将测试以下假设：反复暴饮式饮酒会增加大脑中IL-1(3)的表达，使用小干扰RNA(SiRNA)或IL-13受体拮抗剂阻断1L-1(3)将防止暴饮式酒精饮酒。这些试点项目将为新的研究人员提供资源，以制定对成功获得更大规模的研究拨款至关重要的初步结果。这一努力支持了我们ARC的长期发展和成功。