Biospecimen & Clinical Database Core

生物样本

• 批准号: 10706319
• 负责人: Rafael Fonseca
• 金额: $ 46.35万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706319
• 关键词: Algorithms; Aliquot; Area; Arizona; Bioinformatics; Biological; Biological Specimen database; Biometry; Blood; Blood specimen; Bone Marrow; Bortezomib; COVID-19 pandemic; Cancer Center; Classification; Clinic; Clinical Data; Clinical Research; Clinical Trials; Collection; Data; Data Collection; Data Set; Databases; Dedications; Development; Disease; Early Diagnosis; Electronics; Florida; Funding; Geographic Locations; Goals; Grant; Individual; Information Systems; Infrastructure; Institution; Institutional Review Boards; K-Series Research Career Programs; Laboratories; Light-Chain Immunoglobulins; Link; Medicine; Metadata; Monoclonal gammopathy of uncertain significance; Multi-Institutional Clinical Trial; Multiple Myeloma; Natural Language Processing; Outcomes Research; Pathogenesis; Pathology; Patient Recruitments; Patients; Performance; Plasma Cells; Prevention; Process; Protocols documentation; Quality Control; Records; Regimen; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Safety; Sampling; Services; Specimen; System; Time; Tissue Banks; Translational Research; Tumor Tissue; Vesicular stomatitis Indiana virus; Virotherapy; Visit; Waldenstrom Macroglobulinemia; archive data; base; career; clinical database; clinical practice; clinical translation; data archive; data handling; data harmonization; design; high risk; innovation; migration; multiple omics; peripheral blood; primary amyloidosis of light chain type; programs; research and development; therapy outcome; translational study; treatment response; user-friendly

PROJECT SUMMARY/ABSTRACT This Biospecimens, Pathology, and Clinical Database Core will not only furnish essential services for the individual projects by managing patient data, safety, and samples, but it will provide a link between clinical data and research outcomes and interface with the Biostatistics and Bioinformatics Core to allow for formal interactions between existing datasets to develop relational networks. It will accomplish its goals by integrating with and building upon existing, successful infrastructure housed at the Mayo Clinic, making the Core an efficient, integral component of this SPORE. The significant patient referral base and clinical practice at the Mayo Clinic (>10,000 patient visits annually with multiple myeloma and related conditions) will allow substantial patient recruitment to the clinical trials and translational studies in this Mayo SPORE in multiple myeloma. The already extant 12,000+ bone marrow samples in our Biospecimens Core make SPORE and DRP projects possible. The on-going initiative of collecting data and research specimens from additional myeloma patients will feed into all SPORE projects and make Development Research and Career Development Award Programs possible. The Aims of the Core are: 1. to provide support for collection, transport, processing and storage of samples; 2. to supply the data system infrastructure to track all SPORE patients and samples; 3. to provide coordination and oversight of distribution of samples to SPORE investigators; and 4. to serve as a resource of expertise, collaborative support and service for full projects as well as Career Enhancement and Developmental Research Awardee research. This Core provides a mechanism of consistent and compatible data handling, thereby facilitating management of collected data and integration with data from existing Mayo resources. Areas of data support include database development, data form development and processing, quality control, data collection and entry, and data archiving. This Core is unique not only in its scope and potential, but also in that it will be built on existing (but currently unfunded) tissue banking facilities and processes at the Mayo Clinic in Rochester and in Arizona, guaranteeing successful performance. Finally, the Core will interface with the clinical research components of other SPORE grantees and cancer centers to facilitate multi-institutional clinical research arising out of national myeloma research efforts.

项目总结/文摘