Biospecimen & Clinical Database Core

生物样本

• 批准号: 10488645
• 负责人: Rafael Fonseca
• 金额: $ 46.99万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488645
• 关键词: Algorithms; Aliquot; Area; Arizona; Bioinformatics; Biological; Biological Specimen database; Biometry; Blood; Blood specimen; Bone Marrow; Bortezomib; COVID-19 pandemic; Cancer Center; Clinic; Clinical Data; Clinical Pathology; Clinical Research; Clinical Trials; Collection; Data; Data Collection; Data Set; Databases; Development; Disease; Early Diagnosis; Florida; Funding; Geographic Locations; Goals; Grant; Individual; Information Systems; Infrastructure; Institutional Review Boards; K-Series Research Career Programs; Laboratories; Light-Chain Immunoglobulins; Link; Medicine; Metadata; Monoclonal gammopathy of uncertain significance; Multi-Institutional Clinical Trial; Multiple Myeloma; Natural Language Processing; Outcomes Research; Pathogenesis; Pathology; Patient Recruitments; Patients; Performance; Plasma Cells; Prevention; Process; Protocols documentation; Quality Control; Records; Regimen; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Safety; Sampling; Services; Specimen; System; Time; Tissues; Translational Research; Tumor Tissue; Vesicular stomatitis Indiana virus; Virotherapy; Visit; Waldenstrom Macroglobulinemia; archive data; base; career; clinical database; clinical practice; data archive; data handling; data harmonization; data integration; design; high risk; innovation; multiple omics; peripheral blood; primary amyloidosis of light chain type; programs; research and development; therapy outcome; translational study; treatment response; user-friendly

PROJECT SUMMARY/ABSTRACT This Biospecimens, Pathology, and Clinical Database Core will not only furnish essential services for the individual projects by managing patient data, safety, and samples, but it will provide a link between clinical data and research outcomes and interface with the Biostatistics and Bioinformatics Core to allow for formal interactions between existing datasets to develop relational networks. It will accomplish its goals by integrating with and building upon existing, successful infrastructure housed at the Mayo Clinic, making the Core an efficient, integral component of this SPORE. The significant patient referral base and clinical practice at the Mayo Clinic (>10,000 patient visits annually with multiple myeloma and related conditions) will allow substantial patient recruitment to the clinical trials and translational studies in this Mayo SPORE in multiple myeloma. The already extant 12,000+ bone marrow samples in our Biospecimens Core make SPORE and DRP projects possible. The on-going initiative of collecting data and research specimens from additional myeloma patients will feed into all SPORE projects and make Development Research and Career Development Award Programs possible. The Aims of the Core are: 1. to provide support for collection, transport, processing and storage of samples; 2. to supply the data system infrastructure to track all SPORE patients and samples; 3. to provide coordination and oversight of distribution of samples to SPORE investigators; and 4. to serve as a resource of expertise, collaborative support and service for full projects as well as Career Enhancement and Developmental Research Awardee research. This Core provides a mechanism of consistent and compatible data handling, thereby facilitating management of collected data and integration with data from existing Mayo resources. Areas of data support include database development, data form development and processing, quality control, data collection and entry, and data archiving. This Core is unique not only in its scope and potential, but also in that it will be built on existing (but currently unfunded) tissue banking facilities and processes at the Mayo Clinic in Rochester and in Arizona, guaranteeing successful performance. Finally, the Core will interface with the clinical research components of other SPORE grantees and cancer centers to facilitate multi-institutional clinical research arising out of national myeloma research efforts.

项目摘要/摘要 这个生物化学、病理学和临床数据库核心不仅将为 通过管理患者数据、安全性和样本的单个项目，但它将在临床数据之间提供链接 和研究成果以及与生物统计和生物信息学核心的接口，以允许正式 现有数据集之间的交互，以开发关系网络。它将通过整合来实现其目标 利用并建立在梅奥诊所现有的、成功的基础设施上，使核心成为 该孢子的有效的、不可或缺的组成部分。 梅奥诊所重要的患者转诊基础和临床实践(&gt；每年有10,000名患者来访， 多发性骨髓瘤和相关疾病)将允许大量患者招募到临床试验和 多发性骨髓瘤的这个梅奥孢子的翻译研究。已经存在的12,000多个骨髓 我们生物样品芯中的样品使孢子和DRP项目成为可能。正在进行的倡议 从更多的骨髓瘤患者收集数据和研究样本将提供给所有孢子项目和 使发展研究和职业发展奖计划成为可能。核心的目标是： 1.为样本的收集、运输、加工和储存提供支持； 2.提供追踪所有孢子病患者和样本的数据系统基础设施； 3.协调和监督向孢子调查人员分发样本；以及 4.为所有项目和职业提供专业知识、协作支持和服务 增强和发展研究获奖者研究。 该核心提供了一致和兼容的数据处理机制，从而便于管理 收集的数据并与现有梅奥资源的数据整合。数据支持领域包括 数据库开发、数据表格开发和处理、质量控制、数据收集和录入以及 数据存档。这一核心的独特之处不仅在于它的范围和潜力，还在于它将建立在现有的基础上 (但目前没有资金)罗切斯特和亚利桑那州梅奥诊所的组织库设施和程序， 保证了成功的业绩。最后，核心将与临床研究组成部分对接 其他孢子受赠者和癌症中心，以促进由国家 骨髓瘤的研究努力。