Biospecimen & Clinical Database Core

生物样本

• 批准号: 10270453
• 负责人: Rafael Fonseca
• 金额: $ 46.24万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270453
• 关键词: Algorithms; Aliquot; Area; Arizona; Bioinformatics; Biological; Biological Specimen database; Biometry; Blood; Blood specimen; Bone Marrow; Bortezomib; COVID-19 pandemic; Cancer Center; Clinic; Clinical Data; Clinical Pathology; Clinical Research; Clinical Trials; Collection; Data; Data Collection; Data Set; Databases; Development; Disease; Early Diagnosis; Florida; Funding; Geographic Locations; Goals; Grant; Individual; Information Systems; Infrastructure; Institutional Review Boards; K-Series Research Career Programs; Laboratories; Light-Chain Immunoglobulins; Link; Medicine; Metadata; Monoclonal gammopathy of uncertain significance; Multi-Institutional Clinical Trial; Multiple Myeloma; Natural Language Processing; Outcomes Research; Pathogenesis; Pathology; Patient Recruitments; Patients; Performance; Plasma Cells; Prevention; Process; Protocols documentation; Quality Control; Records; Regimen; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Safety; Sampling; Services; Specimen; System; Time; Tissues; Translational Research; Tumor Tissue; Vesicular stomatitis Indiana virus; Virotherapy; Visit; Waldenstrom Macroglobulinemia; archive data; base; career; clinical database; clinical practice; data archive; data handling; data harmonization; data integration; design; high risk; innovation; multiple omics; peripheral blood; primary amyloidosis of light chain type; programs; research and development; therapy outcome; translational study; treatment response; user-friendly

PROJECT SUMMARY/ABSTRACT This Biospecimens, Pathology, and Clinical Database Core will not only furnish essential services for the individual projects by managing patient data, safety, and samples, but it will provide a link between clinical data and research outcomes and interface with the Biostatistics and Bioinformatics Core to allow for formal interactions between existing datasets to develop relational networks. It will accomplish its goals by integrating with and building upon existing, successful infrastructure housed at the Mayo Clinic, making the Core an efficient, integral component of this SPORE. The significant patient referral base and clinical practice at the Mayo Clinic (>10,000 patient visits annually with multiple myeloma and related conditions) will allow substantial patient recruitment to the clinical trials and translational studies in this Mayo SPORE in multiple myeloma. The already extant 12,000+ bone marrow samples in our Biospecimens Core make SPORE and DRP projects possible. The on-going initiative of collecting data and research specimens from additional myeloma patients will feed into all SPORE projects and make Development Research and Career Development Award Programs possible. The Aims of the Core are: 1. to provide support for collection, transport, processing and storage of samples; 2. to supply the data system infrastructure to track all SPORE patients and samples; 3. to provide coordination and oversight of distribution of samples to SPORE investigators; and 4. to serve as a resource of expertise, collaborative support and service for full projects as well as Career Enhancement and Developmental Research Awardee research. This Core provides a mechanism of consistent and compatible data handling, thereby facilitating management of collected data and integration with data from existing Mayo resources. Areas of data support include database development, data form development and processing, quality control, data collection and entry, and data archiving. This Core is unique not only in its scope and potential, but also in that it will be built on existing (but currently unfunded) tissue banking facilities and processes at the Mayo Clinic in Rochester and in Arizona, guaranteeing successful performance. Finally, the Core will interface with the clinical research components of other SPORE grantees and cancer centers to facilitate multi-institutional clinical research arising out of national myeloma research efforts.

项目总结/摘要 该生物标本、病理学和临床数据库核心不仅将为 通过管理患者数据，安全性和样本，但它将提供临床数据之间的联系 和研究成果，并与生物统计学和生物信息学核心接口， 现有数据集之间的相互作用，以开发关系网络。它将通过整合 利用并建立在现有的，成功的基础设施设在马约诊所，使核心 这是这个SPORE的一个重要组成部分。 马约诊所的重要患者转诊基础和临床实践（每年有超过10，000名患者就诊， 多发性骨髓瘤和相关病症）将允许临床试验招募大量患者， 马约SPORE在多发性骨髓瘤中的翻译研究。已经存在的12，000+骨髓 我们生物样本核心中的样本使SPORE和DRP项目成为可能。正在进行的倡议， 从其他骨髓瘤患者中收集数据和研究样本将纳入所有SPORE项目， 使发展研究和职业发展奖励计划成为可能。核心的目标是： 1.为样本的收集、运输、处理和储存提供支持; 2.提供数据系统基础设施，以跟踪所有SPORE患者和样本; 3.协调和监督向SPORE调查人员分发样本;以及 4.作为专业知识，协作支持和服务的资源，为整个项目以及职业生涯 增强和发展研究奖获得者的研究。 该核心提供了一致和兼容的数据处理机制，从而便于管理 收集的数据和与现有马约资源的数据整合。数据支持领域包括 数据库开发、数据表格开发和处理、质量控制、数据收集和输入，以及 数据归档。这一核心的独特之处不仅在于其范围和潜力，而且在于它将建立在现有的基础上。 (but目前没有资金）在罗切斯特和亚利桑那州的马约诊所的组织库设施和过程， 保证成功的业绩。最后，核心将与以下临床研究组成部分对接： 其他SPORE资助者和癌症中心，以促进国家癌症研究所产生的多机构临床研究。 骨髓瘤研究工作。