Rheumatic and Autoimmune Diseases in Minority Communities

少数民族社区的风湿病和自身免疫性疾病

• 批准号: 10709757
• 负责人: Michael Ward
• 金额: $ 68.7万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709757
• 关键词: Adult; Area; Arthritis; Assessment tool; Autoimmune; Autoimmune Diseases; COVID-19; Clinic; Clinical; Complementary and alternative medicine; Diagnosis; District of Columbia; Evaluation; Goals; Immune; Improve Access; Informed Consent; Intervention; Methods; Minority Groups; Musculoskeletal; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Neighborhood Health Center; Observational Study; Outcome; Outcome Assessment; Patient Self-Report; Patients; Process; Research; Research Personnel; Research Support; Rheumatism; Rheumatoid Arthritis; Serology; Site; Standardization; Symptoms; Systemic Lupus Erythematosus; Vaccines; Vascular Diseases; Washington; Yoga; barrier to care; care providers; cohort; disease phenotype; ethnic difference; ethnic minority; experience; health disparity; improved; metropolitan; minority communities; outreach; pediatric patients; response; standard of care; systemic autoimmunity; systemic inflammatory response

This project studies the clinical presentation of rheumatic diseases in an underserved, largely ethnic minority community in the Washington, DC metropolitan area. Through the NIAMS Community Health Center, subjects with rheumatic complaints are evaluated and provide clinicians with first-hand experience in understanding ethnic differences in autoimmune disease phenotypes as well as barriers to care. This project has supported research on cultural differences in understanding standardized self-report outcome assessment tools, determination of clinically important improvements in rheumatoid arthritis, use of complementary and alternative medicine in patients with rheumatic symptoms, acceptability of yoga as a treatment for arthritis by minority individuals, and understanding of the research process and informed consent among ethnic minorities. In addition, researchers have examined interventions to improve the referral process between primary care providers and subspecialists. Serological studies are currently underway to examine immune abnormalities in patients with rheumatoid arthritis and systemic lupus erythematosus. We have been actively involved in an observational study to characterize how COVID-19 modulates systemic inflammation, autoimmune features and vasculopathy in adult and pediatric patients with a prior diagnosis of systemic autoimmunity, and their overall outcomes including response to antiviral treatments or vaccines. We are also in final stages of opening an additional clinic site in NorthEast Washington D.C. to improve access and increase our outreach to the minority community with rheumatic diseases.

该项目研究了华盛顿特区大都市区一个服务不足、以少数民族为主的社区风湿病的临床表现。通过NIAMS社区卫生中心，对风湿病患者进行评估，为临床医生提供了解自身免疫性疾病表型的种族差异以及护理障碍的第一手经验。该项目支持了以下方面的研究：了解标准化自我报告结果评估工具方面的文化差异；确定类风湿性关节炎临床上重要的改善情况；风湿症状患者使用补充和替代药物；少数族裔个人对瑜伽作为关节炎治疗方法的接受度；以及少数族裔对研究过程和知情同意的了解。此外，研究人员还检查了改善初级保健提供者和专科医生之间转诊过程的干预措施。目前正在进行血清学研究，以检查类风湿性关节炎和系统性红斑狼疮患者的免疫异常。 我们一直积极参与一项观察性研究，以表征新冠肺炎如何调节系统炎症、自身免疫特征和血管病变，以及他们的总体结果，包括对抗病毒治疗或疫苗的反应。 我们还在华盛顿特区东北部开设另一个诊所的最后阶段，以改善获得机会，并增加我们对患有风湿病的少数族裔社区的外联。