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Well-being as a Protective Factor against Cognitive Decline and Dementia Risk

幸福感是预防认知能力下降和痴呆风险的保护因素

基本信息

批准号：
10828474
负责人：
Emily C Willroth
金额：
$ 7.36万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10828474
关键词：
Address Adult Aging Agreement Alzheimer&apos s disease related dementia Amyloid Amyloid beta-Protein Area Autopsy Award Blood Vessels Brain Pathology Buffers Cognitive Collaborations Data Data Analyses Data Collection Dementia Diagnosis Disease Education Elderly Environment Epidemiologist Etiology Health Health behavior Impaired cognition Individual Intervention Knowledge Lewy Bodies Lewy Body Disease Life Link Longevity Longitudinal Studies Measures Medical Memory Mentors Mentorship Modeling Neurobehavioral Manifestations Neurofibrillary Tangles Pathology Pathway interactions Personal Satisfaction Personality Physiological Processes Predictive Factor Psychologist Public Health Research Residual state Risk Factors Sampling Scientist Severities Social Sciences Stress Symptoms Techniques Testing Training Well in self Work career causal model cognitive function comorbidity data analysis pipeline dementia risk demographics design end of life experience hedonic hippocampal sclerosis improved longitudinal dataset medical schools negative affect neuropathology physical conditioning prospective protective factors protein TDP-43 psychosocial religious order study resilience satisfaction skills tau Proteins tau aggregation trait

项目摘要

PROJECT SUMMARY The Pathway to Independence Award will equip the candidate with the knowledge and skills to study well-being as a key protective factor against Alzheimer’s Disease and Related Dementias (ADRD). ADRD is a substantial and rapidly-growing public health burden, with no available disease-modifying treatments. However, not everyone with ADRD-related neuropathology experiences symptoms of dementia. Well-being is an understudied but important predictor of cognitive resilience to ADRD neuropathology, given that it has been associated with ADRD risk and is amenable to intervention. The candidate will evaluate multiple well-being predictors of resilience to ADRD pathology (Aim 1). To address questions related to direction of causality, the candidate will examine bidirectional associations between well-being and cognitive decline in older adults with and without ADRD (Aim 2). To increase the generalizability and replicability of findings, both research aims will be conducted in multiple existing longitudinal datasets. To support the candidate in conducting the proposed research, training in three areas is planned: (a) Alzheimer’s Disease and Related Dementias (ADRD), (b) causal modeling of longitudinal observational data, and (c) Integrative Data Analysis. Training will occur under the mentorship of renowned experts in each field (including two personality and health psychologists, an epidemiologist, and a quantitative psychologist). During the K99 period, the candidate will receive training in ADRD that will be applied to both aims of the proposed research and training in causal modeling techniques that will be used in the second aim of the proposed research. During both periods of the award, the candidate will work with the mentor team to build relationships with existing longitudinal studies and develop an Integrative Data Analysis pipeline. The training environment at the Department of Medical Social Sciences, Northwestern Feinberg School of Medicine will be ideal for the proposed training and research, as well as for developing the candidate’s professional skills. Together, the award will help the candidate launch her research career as an independent scientist with unique expertise in well-being, cognitive and physical health across the lifespan, and longitudinal modeling.

项目总结独立之路奖将为候选人提供学习所需的知识和技能幸福感是预防阿尔茨海默病和相关痴呆(ADRD)的关键保护因素。ADRD是一家公共卫生负担巨大且快速增长，没有可用的疾病修正治疗。然而，并不是每个患有ADRD相关神经病理的人都会经历痴呆症的症状。幸福就是 ADRD神经病理的认知弹性的一个未被充分研究但却很重要的预测因子，因为它已经与ADRD风险相关，并易于干预。候选人将评估多方面的幸福感 ADRD病理恢复能力的预测因子(目标1)。为了解决与因果关系方向相关的问题，候选人将研究老年人幸福感和认知能力下降之间的双向联系和没有ADRD(目标2)。为了增加研究结果的概括性和可重复性，这两个研究目标都将将在多个现有的纵向数据集中进行。支持候选人进行建议的计划在三个领域进行研究和培训：(A)阿尔茨海默病和相关痴呆症，(B) 纵向观测数据的因果建模，以及(C)综合数据分析。培训将在以下条件下进行指导每个领域的知名专家(包括两名人格和健康心理学家，以及流行病学家和定量心理学家)。在K99期间，应聘者将接受 ADRD将应用于拟议研究的目标和因果建模技术培训这将用于拟议研究的第二个目标。在颁奖的两个阶段，候选人将与指导团队合作，与现有的纵向研究建立关系，并制定综合数据分析管道。医学社会科学系的培训环境，西北范伯格医学院将是拟议中的培训和研究的理想选择，以及发展候选人的专业技能。总之，该奖项将帮助候选人启动她的研究作为一名独立科学家，在健康、认知和身体健康方面拥有独特的专业知识寿命和纵向建模。