Neuroimaging Reveals Treatment-Related Changes in DLD: A Randomized Controlled Trial

神经影像学揭示 DLD 中与治疗相关的变化：一项随机对照试验

• 批准号: 10840617
• 负责人: Karla N Washington
• 金额: $ 44.95万
• 依托单位: UNIVERSITY OF TORONTO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10840617
• 关键词: 3 year old; 5 year old; Address; Adult; Aftercare; Award; Basal Ganglia; Behavioral; Brain region; Businesses; Canada; Child; Child Language; Clinical; Cross-Sectional Studies; Data; Decision Making; Development; Diagnosis; Diffusion; Early Intervention; Enrollment; Environment Design; Evaluation; Future; Geography; Goals; High Prevalence; Hippocampus; Image; Impairment; Infant; Intervention; Investigation; Knowledge; Language; Language Delays; Language Development; Language Development Disorders; Language Disorders; Learning; Maintenance; Memory; Methods; Neurobiology; Ontario; Outcome; Parents; Participant; Performance; Population; Population Heterogeneity; Process; Randomized, Controlled Trials; Recording of previous events; Rehabilitation therapy; Reporting; Research; Scanning; Site; Sleep; Speech; Structural defect; System; Temporal Lobe; Testing; Time; Toddler; Treatment outcome; Vocabulary; age group; base; behavior measurement; behavioral response; design; effective intervention; efficacious treatment; epidemiology study; evidence base; experience; follow up assessment; follow-up; improved; insight; knowledge base; neural; neuroimaging; neuromechanism; novel; parent grant; peer; programs; recruit; success; syntax; therapy design; tool

Project Summary/Abstract Late talking represents one of the most common reasons children under 3-years of age are referred for speech-language evaluations, impacting about 10%-20% of children in this age-group. Late talkers (LT) also share similarities with children diagnosed with developmental language disorder (DLD) at 4 – 5 years of age, endorsing the notion that shared neurobiological underpinnings might exist between these two clinical groups. However, little is known about the neural basis of late talking, yet is needed to better inform the design of efficacious therapies that address hallmark delays in syntax and vocabulary. For the DLD population, domain- general processes relating memory and language are being investigated in the parent grant, offering valuable testing ground for also advancing the current knowledge base regarding LT. The Procedural circuit Deficit Hypothesis (PDH) posits that relative strengths and weaknesses exist between procedural (impaired) and declarative (less impaired) memory systems. Structural abnormalities in connections between frontal brain regions and basal ganglia, with underactivation and reduced connectivity also evident. However, cortical and subcortical regions in the temporal lobes, including hippocampus, might be impaired to a lesser degree. This proposed research will use diffusion imaging to describe the neural basis (structural connectivity) of late talking and treatment-related change by way of the PDH. We will gather data regarding LT before, after, and following a break in a well-known parent-led therapy (Target WordTM-The Hanen Program® for Parents of Children who are LT: LT treatment; “business as usual”: LT no treatment) as part of a highly feasible RCT that leverages existing pipelines. We will also include typically developing (TD) peers to inform development vs late talking. Our central hypothesis is that treatment designed to improve syntax and vocabulary will change procedural and declarative networks in association with increases in language function and the degree of improvement may be associated with the underlying neurobiology of baseline syntax and vocabulary deficits. Building on a robust history of recruitment and treatment of toddlers by The Hanen Centre®, and our successful imaging partner, we will enroll 30 LT (n=15 treatment; n=15 controls) and 15 TD peers. Aim 1 will establish the structural connectivity in LT and their TD peers between regions in the procedural learning and declarative networks. In Aim 2, we will establish the neurobiological basis of treatment-related changes in LT only. We examine potential changes in structural connectivity between regions of the procedural learning and declarative memory networks, and investigate whether treatment-related changes occur into the typical range (LT, TD). To meet our scientific goals, we pair behavioral tools (syntax and vocabulary) with neuroimaging to describe co-occurring behavioral performance underlying learning and outcome, while also gathering parental and clinican qualitative data regarding treatment outcomes. This research will contribute novel insights into mechanisms underlying learning and impairment to offer a groundbreaking shift in our understanding of LT.

项目总结/文摘