Northern New England Clinical and Translational Research Network

新英格兰北部临床和转化研究网络

• 批准号: 10841975
• 负责人: CLIFFORD JAMES ROSEN
• 金额: $ 275.26万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-03 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10841975
• 关键词: Acceleration; Acute; Address; Aging; American; Area; Atherosclerosis; Award; Biometry; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Centers of Research Excellence; Chronic; Clinical Data; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Community Health; Community Outreach; Coupled; Cultural Diversity; Data; Development; Diabetes Mellitus; Disease; Education; Environment; Epidemiology; Evaluation; Extramural Activities; Faculty; Foundations; Funding; Funding Mechanisms; Goals; Governing Board; Grant; Health; Healthcare; Human Papilloma Virus Vaccine; Human Resources; Immigrant; Infrastructure; Institution; Leadership; Learning; Link; Maine; Malignant Neoplasms; Mentors; Mentorship; Modeling; Native Americans; New England; New Hampshire; Obesity; Opiate Addiction; Opioid; Passamaquoddy Tribe of Maine; Patient Care; Peer Review; Penobscot; Pilot Projects; Play; Population; Populations at Risk; Post-Acute Sequelae of SARS-CoV-2 Infection; Predisposition; Primary Care; Public Health; Publications; Registries; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Reservations; Resource Sharing; Resources; Role; Rural; Rural Health; Rural Population; Services; Site; Substance Use Disorder; Substance abuse problem; Technology; Toxic Environmental Substances; Training; Training Programs; Translational Research; Tribes; United States Health Resources and Services Administration; United States National Institutes of Health; Universities; Urban Population; Vermont; career; clinical investigation; cohort; community based research; community engagement; community involvement; coronavirus disease; equity, diversity, and inclusion; flexibility; food insecurity; health communication; health difference; health disparity; health equity; improved; innovation; learning progression; novel; novel strategies; patient oriented; post-COVID-19; practice-based research network; primary care practice; programs; rurality; suburban communities; technical report; telehealth; underserved community; urban underserved; vaccine hesitancy

The long-term goal of the Northern New England Clinical and Translational Research Network (NNE-CTR), composed of MaineHealth, the University of Vermont, and the University of Southern Maine, is to sustain a clinical and translational research infrastructure that supports improvements in community health for northern New England inhabitants. Maine and Vermont have the oldest populations in the U.S. and that, coupled with rurality, predisposes residents to a range of disorders ranging from cancer to substance use disorders, food insecurity, obesity, diabetes and cardiovascular disease. In addition, northern New England has a growing underserved immigrant population, as well as a Native American population. Our communities have been challenged by the Covid-19 pandemic, and we are addressing these challenges by linking primary care practice centers with academic centers and developing innovative approaches to community-based research. During our first four years, the NNE-CTR has built a strong foundation for clinical research. We partnered with the oldest regional practice-based research network (PBRN), the Dartmouth Co-Op, and actively supported successful NIH program applications, including two COBREs, two NCI program grants, an infrastructure grant for a new Center for Biomedical Shared Resources, and a HRSA grant to build on the opioid treatment model pioneered in Vermont. The NNE-CTR PI is playing a leadership role in coordinating a national CTR network, including the CTR National COVID Cohort Collaborative (N3C), a registry to share clinical data on Covid-19 nationally, and the NIH-sponsored RECOVER trial, which will define the long-term sequelae of Covid-19. In this renewal, we plan to expand our collaborations both regionally and nationally, strengthen our PBRN, and embrace cultural diversity. We will strengthen Core resources that include: the Biostatistics, Epidemiology and Research Design Core, which will improve data capability and research navigation services; the Professional Development Core, which will offer an array of new educational and mentorship opportunities; the Pilot Projects Program, which will provide new and flexible funding mechanisms to offer more support for community-based projects; the Translational Research and Technology Core, offering state-of-the-art technologies and training for new investigators, and the Community Engagement and Outreach Core, which will build stronger bridges to underserved communities. We propose three specific aims: 1-Expand infrastructure and resources to address clinical and translational research needs in northern New England; 2- Strengthen clinical and translational research that addresses health equity and disparities encountered by at- risk populations, including expansion of clinical trial access, telehealth, and mentored training programs for new investigators; and 3-Accelerate regional and national collaborative initiatives within the IDeA networks and through NIH such as N3C and RECOVER. In sum, we will strengthen the NNE-CTR through continuous learning and improvement supported by the principles of diversity, inclusion, and equity.

北方新英格兰临床和转化研究网络（NNE-CTR）的长期目标， 由缅因健康，佛蒙特大学和南缅因州大学组成，是为了维持一个 支持改善北方社区卫生的临床和转化研究基础设施 新英格兰居民。缅因州和佛蒙特州拥有美国最古老的人口， 农村，使居民容易患上一系列疾病，从癌症到物质使用障碍，食物， 不安全感、肥胖、糖尿病和心血管疾病。此外，北方新英格兰的人口增长 服务不足的移民人口，以及美洲土著人口。我们的社区已经 新冠肺炎疫情的挑战，我们正在通过将初级保健 实践中心与学术中心，并开发创新的方法，以社区为基础的研究。 在我们的头四年，NNE-CTR已经建立了临床研究的坚实基础。我们与 最古老的区域实践研究网络（PBRN），达特茅斯合作，并积极支持 成功的NIH计划申请，包括两个COBREs，两个NCI计划赠款，一个基础设施赠款 建立一个新的生物医学共享资源中心，并获得HRSA赠款，以建立阿片类药物治疗模式 在佛蒙特州开创。NNE-CTR PI在协调国家CTR网络方面发挥领导作用， 包括CTR国家COVID队列协作组织（N3 C），这是一个分享COVID-19临床数据的注册机构 以及NIH赞助的RECOVER试验，该试验将定义COVID-19的长期后遗症。在 这次更新，我们计划扩大我们在区域和国家两级的合作，加强我们的PBRN， 拥抱文化多样性。我们将加强核心资源，包括：生物统计学、流行病学和 研究设计核心，这将提高数据能力和研究导航服务; 发展核心，这将提供一系列新的教育和指导机会;试点 项目计划，该计划将提供新的和灵活的供资机制，以提供更多的支持， 社区项目;转化研究和技术核心，提供最先进的 新调查人员的技术和培训，以及社区参与和外展核心， 将为服务不足的社区搭建更牢固的桥梁。我们提出三个具体目标：1-扩大 满足北方新英格兰临床和转化研究需求的基础设施和资源; 2- 加强临床和转化研究，解决卫生公平和差距所遇到的at- 风险人群，包括扩大临床试验访问，远程医疗，和指导培训计划， 新的研究人员; 3-加快在IDEA网络内的区域和国家合作计划 如N3 C和RECOVER。总括而言，我们会继续透过以下措施， 学习和改进的多样性，包容性和公平的原则支持。