Early predictors of Late Talking (LT) in infancy

婴儿期晚说话 (LT) 的早期预测因素

• 批准号: 10839687
• 负责人: Tian Zhao
• 金额: $ 38.35万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10839687
• 关键词: Address; Age; Age Months; Child; Communities; Data; Data Collection; Data Set; Development; Early Intervention; Enrollment; Environment; Exclusion; Exhibits; Family member; Future; Growth; Home environment; Infant; Infrastructure; Investments; Language; Language Delays; Language Development; Language Development Disorders; Language Disorders; Learning; Longitudinal Studies; Measurement; Measures; Outcome; Parents; Phonetics; Populations at Risk; Process; Reporting; Research; Risk; School-Age Population; Speech; Speech Delay; Speech Disorders; Subgroup; System; Systems Analysis; Testing; Time; Vocabulary; falls; follow-up; hearing impairment; high risk; high risk infant; high risk population; indexing; infancy; multidimensional data; multimodal data; nervous system disorder; neural; neuroimaging; parent grant; parent project; participant enrollment; recruit; skills; speech processing

Project Summary/Abstract Infant speech learning during the sensitive period for phonetic learning has been shown repeatedly to predict language abilities up to school age, with the potential to also mark atypical language development. One important factor influencing the outcome of the sensitive period and subsequent language development trajectory is the quality and quantity of language input in infancy. As infants develop, a substantial subgroup will start to show delay in language emergence, starting around 18 months of age, even after excluding primary factors such as hearing impairment, ASD and other neurological disorders. Many Late Talkers will have persistent speech and language delays (e.g., Developmental Language Disorder) into school age and beyond. Even those who eventually achieve language scores within the average range still score lower than typically developing children. Late- talkers might thus provide a first clue of DLD, making them an important group to study. Yet, little is known regarding their early predictors. In my current parent Katz ESI R01, we are focusing on investigating whether infants at High Risk of developing DLD (i.e., with first-degree family member who exhibit speech and language disorders) already demonstrate altered neural processing of speech at 6, 12 and 14 months of age, straddling the sensitive period, compared to their Low Risk typically developing counterpart. The parent grant thus offers an optimal infrastructure for this proposed supplement project to start examining research questions related to early predictors of late talkers by adding additional measurements at additional time points. Specifically, we plan to examine two potential early predictors, namely being at High-Risk of DLD and language input in infancy. To characterize infants’ language abilities in toddlerhood, we plan to recruit all infants (i.e., both Low- Risk and High-Risk groups) in the parent grant longitudinal study to further enroll in the MacArthur- Bates Communicative Development Index (CDI) parental reports at 18, 21, 24, 27, 30 months of age. To characterize language input in infancy (e.g., amount of IDS), we plan to recruit all infants at 9 months of age (i.e., in the middle of the sensitive period) for daylong audio recordings of their home environment, using the Language Environment Analysis (LENA) system. Together, these additional measures collected in the supplement project will not only address two important questions regarding the early predictors of Late Talking, but will also help create a valuable multimodal dataset to share with the scientific community at the end of the parent grant. Testing these hypotheses will likely open many opportunities for follow-up questions. For example, in conjunction with the neuroimaging data collected through the parent grant, we can test if combining language input, infant neural processing of speech and risk-level can better predict late language emergence than any single factor.

项目总结/摘要 婴儿在语音学习敏感期的语音学习已经被反复证明， 预测学龄前的语言能力，并有可能标记非典型语言 发展影响敏感期及其后结果的一个重要因素是， 语言发展轨迹是婴儿期语言输入的质和量。像婴儿带 发展，一个重要的亚组将开始显示语言出现延迟，从18岁左右开始， 月龄，即使排除主要因素，如听力障碍，ASD和其他 神经系统疾病许多说话晚的人会有持续的言语和语言延迟（例如， 发展性语言障碍）进入学龄及以后。即使是那些最终 在平均范围内的语言分数仍然低于正常发育的儿童。晚- 因此，谈话者可能提供了DLD的第一个线索，使他们成为一个重要的研究群体。然而， 关于他们的早期预测。在我现在的父母Katz ESI R 01中，我们专注于 调查是否有发生DLD的高风险的婴儿（即，一级亲属 表现出言语和语言障碍的人）已经表现出改变的神经处理， 在6个月，12个月和14个月大的讲话，跨越敏感期，与他们的低风险相比， 典型的发展中国家。因此，父母补助金为此提供了最佳基础设施 拟议的补充项目，开始审查与晚期癌症早期预测因素有关的研究问题， 通过在额外的时间点增加额外的测量值。具体来说，我们计划检查 两个潜在的早期预测因素，即处于DLD的高风险和婴儿期的语言输入。到 为了表征幼儿期婴儿的语言能力，我们计划招募所有婴儿（即，低- 风险和高风险群体）的父母补助纵向研究，以进一步参加麦克阿瑟- 在18、21、24、27、30个月龄时的Bates沟通发展指数（CDI）父母报告。 为了表征婴儿期的语言输入（例如，我们计划在9岁时招募所有婴儿， 月龄（即，在敏感期的中间）进行为期一天的家中录音 环境，使用语言环境分析（LENA）系统。这些额外的 补充项目中收集的措施不仅将解决两个重要问题， Late Talking的早期预测因素，但也将有助于创建一个有价值的多模式数据集来分享 在家长资助结束时与科学界进行交流。测试这些假设可能会打开 有很多机会提出后续问题。例如，结合神经成像数据， 通过父母的资助，我们可以测试，如果结合语言输入，婴儿的神经处理， 言语能力和风险水平比任何单一因素都能更好地预测晚期语言出现。