Mechanisms of action of the antigen presenting cells that impair lymphoma-specific cytotoxic T lymphocytes

抗原呈递细胞损害淋巴瘤特异性细胞毒性 T 淋巴细胞的作用机制

• 批准号: nhmrc : 575540
• 负责人: Prof Jose Villadangos
• 金额: $ 19.74万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-action-antigen-t-lymphocytes/101335
• 关键词: Mechanisms; action; antigen; presenting; cells

Our immune systems are continually fighting cancer. However, the cancer cells occasionally acquire mutations that enable them to subvert the immune system. Usually they do this by hiding under the appearance of normal tissue, but sometimes they activate the very mechanisms that are in place to shut-down immune responses when these are no longer necessary. The goal of this proposal is to identify such mechanisms and find ways of bypassing them, thus restoring anti-tumour activity in patients.

我们的免疫系统一直在与癌症作斗争。然而，癌细胞偶尔会获得突变，使它们能够破坏免疫系统。通常情况下，它们会隐藏在正常组织的外表下，但有时它们会激活已经存在的机制，在不再需要免疫反应时关闭免疫反应。这项提议的目标是确定这样的机制，并找到绕过它们的方法，从而恢复患者的抗肿瘤活性。