Expression and substrate recognition by MARCH ubiquitin ligases

MARCH 泛素连接酶的表达和底物识别

• 批准号: DP110101383
• 负责人: Prof Jose Villadangos
• 金额: $ 21.11万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-10-31 至 2014-10-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110101383
• 关键词: Expression; substrate; recognition; MARCH; ubiquitin

Eukaryotic cells are compartmentalised, with different organelles playing distinct functions. This project will characterise the MARCHs, proteins which control the localisation and half-life of other proteins. Understanding how the MARCHs work will provide novel insights into fundamental cellular processes that play major roles in many biological functions.

真核细胞是区隔的，不同的细胞器发挥不同的功能。该项目将表征MARCHs，控制其他蛋白质的定位和半衰期的蛋白质。了解MARCHs如何工作将为了解在许多生物功能中发挥重要作用的基本细胞过程提供新的见解。