A novel link between metabolism and host defence
A novel link between metabolism and host defence
批准号:
DP190102213
负责人:
Prof Jose Villadangos
金额:
$36.51万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 2021-12-31
中文摘要
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英文摘要
This project aims to delineate how a protein modification that consists of the addition of a small sugar to cellular proteins, known as O-GlcNAcylation, provides a link between metabolism and complex cell functions. The model for these studies is a cell type of the immune system known as dendritic cells. Upon encountering pathogens these cells undergo metabolic changes that increase the rate of O-GlcNAcylation of proteins involved in immune responses, altering their function. This project will study how O-GlcNAcylation works and is regulated. The project expects to develop new technology and provide high-level training, increasing the competitiveness of the strategic biotechnology sector in Australia
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会议论文
A novel axis of cooperation between innate and adaptive immunity
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批准号:DP220102288
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项目类别:Discovery Projects
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资助金额:$43.1万
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负责人:Prof Jose Villadangos
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Antigen presentation in health and disease
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负责人:Prof Jose Villadangos
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依托单位:
A mechanism for pathogen detection highly conserved in mammals
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批准号:DP170102471
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项目类别:Discovery Projects
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财政年份:2017
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依托单位:
Characterisation of membrane protein ubiquitination by MARCH ligases
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批准号:DP160103134
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项目类别:Discovery Projects
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资助金额:$44.31万
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财政年份:2016
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负责人:Prof Jose Villadangos
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依托单位:
Biochemistry and cell biology of antigen presentation and T cell activation
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批准号:nhmrc : 1058193
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项目类别:Research Fellowships
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资助金额:$50.9万
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财政年份:2014
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负责人:Prof Jose Villadangos
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依托单位:
Dendritic Cells and Antigen Presentation
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批准号:nhmrc : GNT1058193
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项目类别:Research Fellowships
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资助金额:$72.76万
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财政年份:2014
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负责人:Prof Jose Villadangos
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依托单位:
Expression and substrate recognition by MARCH ubiquitin ligases
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批准号:DP110101383
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项目类别:Discovery Projects
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资助金额:$21.11万
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财政年份:2011
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负责人:Prof Jose Villadangos
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 575508
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项目类别:NHMRC Research Fellowships
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资助金额:$40.17万
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财政年份:2009
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负责人:Prof Jose Villadangos
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依托单位:
Mechanisms of action of the antigen presenting cells that impair lymphoma-specific cytotoxic T lymphocytes
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批准号:nhmrc : 575540
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项目类别:NHMRC Project Grants
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资助金额:$19.74万
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财政年份:2009
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负责人:Prof Jose Villadangos
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依托单位:
Characterisation of the biochemical and cell biological mechanisms of cross-presentation in dendritic cells
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批准号:nhmrc : 461254
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项目类别:NHMRC Project Grants
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资助金额:$20.26万
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财政年份:2007
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负责人:Prof Jose Villadangos
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依托单位:
Contribution of dendritic cell paralysis to the immunosuppression associated with systemic infections
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批准号:nhmrc : 461255
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项目类别:NHMRC Project Grants
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资助金额:$32.68万
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财政年份:2007
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负责人:Prof Jose Villadangos
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依托单位:
Regulation of synthesis, dimerisation and secretion of the amyloidogenic protease inhibitor cystatin C
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批准号:nhmrc : 461253
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项目类别:NHMRC Project Grants
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资助金额:$28.24万
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财政年份:2007
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负责人:Prof Jose Villadangos
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依托单位:
国内基金
海外基金
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