课题基金 / 基金详情

A novel link between metabolism and host defence

A novel link between metabolism and host defence
新陈代谢和宿主防御之间的新联系
批准号:
DP190102213
负责人:
Prof Jose Villadangos
金额:
$36.51万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 2021-12-31

项目摘要

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中文摘要
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英文摘要
This project aims to delineate how a protein modification that consists of the addition of a small sugar to cellular proteins, known as O-GlcNAcylation, provides a link between metabolism and complex cell functions. The model for these studies is a cell type of the immune system known as dendritic cells. Upon encountering pathogens these cells undergo metabolic changes that increase the rate of O-GlcNAcylation of proteins involved in immune responses, altering their function. This project will study how O-GlcNAcylation works and is regulated. The project expects to develop new technology and provide high-level training, increasing the competitiveness of the strategic biotechnology sector in Australia
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A novel axis of cooperation between innate and adaptive immunity
  • 批准号:
    DP220102288
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $43.1万
  • 财政年份:
    2022
  • 负责人:
    Prof Jose Villadangos
  • 依托单位:
Antigen presentation in health and disease
  • 批准号:
    nhmrc : GNT1154502
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $78.54万
  • 财政年份:
    2019
  • 负责人:
    Prof Jose Villadangos
  • 依托单位:
A mechanism for pathogen detection highly conserved in mammals
  • 批准号:
    DP170102471
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $35.94万
  • 财政年份:
    2017
  • 负责人:
    Prof Jose Villadangos
  • 依托单位:
Characterisation of membrane protein ubiquitination by MARCH ligases
  • 批准号:
    DP160103134
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $44.31万
  • 财政年份:
    2016
  • 负责人:
    Prof Jose Villadangos
  • 依托单位:
国内基金
海外基金
LINK-A/miR-155-5p/PKM2轴促进有氧糖酵解介导套细胞淋巴瘤伊布替尼耐药的作用机制研究
  • 批准号:
    LQ21H160036
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2020
  • 负责人:
    张烨
  • 依托单位:
高性能功率变换器DC-Link电容模组关键技术研究
  • 批准号:
    51777146
  • 项目类别:
    面上项目
  • 资助金额:
    61.0万元
  • 批准年份:
    2017
  • 负责人:
    朱国荣
  • 依托单位:
载CCL5和Link N的HAP水凝胶招募干细胞修复压力诱导的椎间盘退变
  • 批准号:
    81572204
  • 项目类别:
    面上项目
  • 资助金额:
    57.0万元
  • 批准年份:
    2015
  • 负责人:
    熊晓芊
  • 依托单位:
Corey-Link反应的不对称催化研究及其在天然产物合成中的应用
  • 批准号:
    21272221
  • 项目类别:
    面上项目
  • 资助金额:
    80.0万元
  • 批准年份:
    2012
  • 负责人:
    顾振华
  • 依托单位: