A novel link between metabolism and host defence

新陈代谢和宿主防御之间的新联系

• 批准号: DP190102213
• 负责人: Prof Jose Villadangos
• 金额: $ 36.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102213
• 关键词: novel; link; between; metabolism; host

This project aims to delineate how a protein modification that consists of the addition of a small sugar to cellular proteins, known as O-GlcNAcylation, provides a link between metabolism and complex cell functions. The model for these studies is a cell type of the immune system known as dendritic cells. Upon encountering pathogens these cells undergo metabolic changes that increase the rate of O-GlcNAcylation of proteins involved in immune responses, altering their function. This project will study how O-GlcNAcylation works and is regulated. The project expects to develop new technology and provide high-level training, increasing the competitiveness of the strategic biotechnology sector in Australia

该项目旨在描述蛋白质修饰，包括向细胞蛋白质中添加一种小分子糖，称为O-GlcNAcylation，如何在代谢和复杂的细胞功能之间提供联系。这些研究的模型是免疫系统的一种细胞类型，称为树突状细胞。在遇到病原体时，这些细胞发生代谢变化，增加参与免疫反应的蛋白质的O-GlcNAc化速率，改变其功能。该项目将研究O-GlcNAcylation是如何工作和调节的。该项目预计将开发新技术并提供高水平培训，提高澳大利亚战略生物技术部门的竞争力