A mechanism for pathogen detection highly conserved in mammals
A mechanism for pathogen detection highly conserved in mammals
批准号:
DP170102471
负责人:
Prof Jose Villadangos
金额:
$35.94万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
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英文摘要
This project aims to delineate biochemically how mammals fight pathogens by alerting their immune system to Vitamin B compounds produced by certain bacteria and fungi. The protein MR1 binds the compounds and displays them on the cell surface, activating pathogen-fighting MAIT cells. The MR1-MAIT cell axis is highly conserved in mammals and is thought to defend the host. This project expects to lead to new products to improve veterinary and human health services with new technology developed throughout the project and high-level training which will increase the competitiveness of the strategic biotechnology sector in Australia.
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会议论文
A novel axis of cooperation between innate and adaptive immunity
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批准号:DP220102288
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项目类别:Discovery Projects
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资助金额:$43.1万
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财政年份:2022
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负责人:Prof Jose Villadangos
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依托单位:
Antigen presentation in health and disease
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批准号:nhmrc : GNT1154502
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项目类别:Research Fellowships
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资助金额:$78.54万
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财政年份:2019
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负责人:Prof Jose Villadangos
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依托单位:
A novel link between metabolism and host defence
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批准号:DP190102213
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项目类别:Discovery Projects
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资助金额:$36.51万
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财政年份:2019
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负责人:Prof Jose Villadangos
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依托单位:
Characterisation of membrane protein ubiquitination by MARCH ligases
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批准号:DP160103134
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项目类别:Discovery Projects
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资助金额:$44.31万
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财政年份:2016
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负责人:Prof Jose Villadangos
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依托单位:
Biochemistry and cell biology of antigen presentation and T cell activation
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批准号:nhmrc : 1058193
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项目类别:Research Fellowships
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资助金额:$50.9万
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财政年份:2014
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负责人:Prof Jose Villadangos
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依托单位:
Dendritic Cells and Antigen Presentation
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批准号:nhmrc : GNT1058193
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项目类别:Research Fellowships
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资助金额:$72.76万
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财政年份:2014
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负责人:Prof Jose Villadangos
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依托单位:
Expression and substrate recognition by MARCH ubiquitin ligases
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批准号:DP110101383
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项目类别:Discovery Projects
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资助金额:$21.11万
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财政年份:2011
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负责人:Prof Jose Villadangos
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 575508
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项目类别:NHMRC Research Fellowships
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资助金额:$40.17万
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财政年份:2009
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负责人:Prof Jose Villadangos
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依托单位:
Mechanisms of action of the antigen presenting cells that impair lymphoma-specific cytotoxic T lymphocytes
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批准号:nhmrc : 575540
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项目类别:NHMRC Project Grants
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资助金额:$19.74万
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财政年份:2009
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负责人:Prof Jose Villadangos
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依托单位:
Characterisation of the biochemical and cell biological mechanisms of cross-presentation in dendritic cells
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批准号:nhmrc : 461254
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项目类别:NHMRC Project Grants
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资助金额:$20.26万
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财政年份:2007
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负责人:Prof Jose Villadangos
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依托单位:
Contribution of dendritic cell paralysis to the immunosuppression associated with systemic infections
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批准号:nhmrc : 461255
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项目类别:NHMRC Project Grants
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资助金额:$32.68万
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财政年份:2007
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负责人:Prof Jose Villadangos
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依托单位:
Regulation of synthesis, dimerisation and secretion of the amyloidogenic protease inhibitor cystatin C
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批准号:nhmrc : 461253
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项目类别:NHMRC Project Grants
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资助金额:$28.24万
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财政年份:2007
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负责人:Prof Jose Villadangos
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依托单位:
国内基金
海外基金
基于质谱贴片的病原菌标志物检测及伤口感染诊断应用
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批准号:82372148
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项目类别:面上项目
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资助金额:60.00万元
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批准年份:2023
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负责人:黄琳
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依托单位:
基于纳米金属有机框架(MOFs)荧光生物探针的病原微生物(Pathogen)高灵敏电化学快速检测方法研究
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批准号:31870078
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项目类别:面上项目
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资助金额:25.0万元
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批准年份:2018
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负责人:刘坤平
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依托单位:
“寒淫”轻重强度致病及转归的转录组与代谢组整合研究
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批准号:30873212
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项目类别:面上项目
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资助金额:28.0万元
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批准年份:2008
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负责人:陈康
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依托单位: