A mechanism for pathogen detection highly conserved in mammals

哺乳动物中高度保守的病原体检测机制

• 批准号: DP170102471
• 负责人: Prof Jose Villadangos
• 金额: $ 35.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170102471
• 关键词: mechanism; pathogen; detection; highly; conserved

This project aims to delineate biochemically how mammals fight pathogens by alerting their immune system to Vitamin B compounds produced by certain bacteria and fungi. The protein MR1 binds the compounds and displays them on the cell surface, activating pathogen-fighting MAIT cells. The MR1-MAIT cell axis is highly conserved in mammals and is thought to defend the host. This project expects to lead to new products to improve veterinary and human health services with new technology developed throughout the project and high-level training which will increase the competitiveness of the strategic biotechnology sector in Australia.

该项目旨在描述哺乳动物如何通过生物化学方式对抗病原体，提醒它们的免疫系统注意某些细菌和真菌产生的维生素B化合物。蛋白质MR 1结合这些化合物并将它们展示在细胞表面，激活对抗病原体的MAIT细胞。MR 1-MAIT细胞轴在哺乳动物中是高度保守的，被认为可以保护宿主。该项目预计将产生新产品，以改善兽医和人类健康服务，并在整个项目中开发新技术和高水平培训，这将提高澳大利亚战略生物技术部门的竞争力。