Adolescent Markers of Depression and the Impact of Alcohol Use

青少年抑郁症的标志和饮酒的影响

• 批准号: 10852676
• 负责人: Alejandro Daniel Meruelo
• 金额: $ 7.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10852676
• 关键词: Address; Administrative Supplement; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Alcohol consumption; Alcohols; Amygdaloid structure; Anisotropy; Anterior; Applications Grants; Area; Award; Basal Ganglia; Bilateral; Birth; Brain; Brain imaging; COVID-19 pandemic; Cerebellum; Characteristics; Classification; Classification Scheme; Clinical; Computational Biology; Corpus Callosum; Corpus striatum structure; DSM-V; Data; Depressed mood; Development; Diffusion Magnetic Resonance Imaging; Disease; Early Intervention; Early treatment; Exhibits; Fiber; Funding; Fusiform gyrus; Goals; Health system; Heavy Drinking; Hippocampus; Imaging Techniques; Individual; Inferior; Investigation; Lead; Left; Life; Linear Regressions; Link; Long-Term Depression; Longitudinal Studies; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Medial; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentorship; Metabolic; Modeling; Monitor; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Occipital lobe; Patient Self-Report; Patients; Play; Positioning Attribute; Postdoctoral Fellow; Principal Component Analysis; Process; Quality of life; Reporting; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Running; Sampling; Societies; Son; Stress; Structure; Surface; Symptoms; Teenagers; Testing; Thalamic structure; Thick; Thinness; Time; Training; Youth; alcohol comorbidity; alcohol use disorder; binge drinking; brain magnetic resonance imaging; career; career development; child depression; cingulate cortex; clinically significant; comorbid depression; comorbidity; corpus callosum body; cost; depressive symptoms; design; drinking; follow-up; frontal lobe; gray matter; improved; innovation; lateral ventricle; longitudinal analysis; morphometry; mortality; multidisciplinary; neural; neurodevelopment; neuroimaging; poor health outcome; recruit; responsible research conduct; skill acquisition; statistics; structural imaging; substance use; symptomatology; thalamocortical tract; underage drinking; white matter

PROJECT SUMMARY This K23 award will allow Dr. Meruelo to become an expert on the relationship between adolescent alcohol use and depression. During his training, he proposes to address that untreated alcohol use disorder and depression lead to poor health outcomes ultimately affecting both quality and quantity of life. Dr. Meruelo plans to use an innovative approach and multiple imaging techniques of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA), in a longitudinal study to identify brain features that address the temporal relationship between these two comorbid disorders. Identifying risk factors is of critical importance to anticipating which individuals would benefit from earlier interventions and treatment to reduce morbidity and mortality directly. The award will provide him the support needed to develop expertise in four areas: (1) adolescent alcohol use and major depression, (2) neuroimaging and brain development, (3) advanced statistics, and (4) execution of longitudinal studies. To achieve the K23's goals, Dr. Meruelo has assembled an expert multidisciplinary team. Drs Tapert and Brown will facilitate guidance and access to the activities of and NCANDA data that addresses one of NIAAA's major initiatives. They will also provide expertise in adolescent alcohol use and comorbid depression and on planning, recruiting, and implementing longitudinal study designs with adolescents, as well as career and mentorship on the responsible conduct of research. Dr. Schuckit will provide expertise on comorbidity between alcohol and depression and other career development skills. Dr. Thomas will provide training in advanced longitudinal analyses of associated data. The K23 research specific aims are to identify whether the causal relationships between adolescent alcohol use and long-term depression using latent difference score models to distinguish cause and effect (Aim 1). The common factor of stress and subsequent depression and/or substance use is critical to understanding their impact on growing adolescents. The second (Aim 2) seeks to identify morphometrics that predict the development of depression in healthy adolescents using: (a) Naïve Bayesian classifier, and (b) principal component analysis with subsequent hierarchical linear regression. The necessary NCANDA data is available to begin addressing central questions of the proposal. Additional data from later years have become available during the K23 award period and is being incorporated into the analysis. An administrative supplement will provide bridge funding for a fellow to assist with additional investigations needed to complete Aims 1 and 2, disrupted by the birth of my son and the COVID-19 pandemic, and strengthen my grant applications in my path to becoming an independent investigator.

项目摘要 该K23奖将使Meruelo博士成为青少年之间关系的专家 酒精使用和抑郁。在培训期间，他提议解决未经治疗的酒精使用 疾病和抑郁导致健康状况不佳，最终影响了生活的质量和数量。 Meruelo博士计划使用国家 /地区的创新方法和多种成像技术 在纵向研究中 大脑特征解决这两种合并症之间的临时关系。识别 风险因素对于预期哪些人将从早期受益至关重要 干预措施和治疗，直接降低发病率和死亡率。该奖项将为他提供 在四个领域发展专业知识所需的支持：（1）青少年饮酒和重大抑郁症，（2） 神经影像学和大脑发育，（3）高级统计和（4）执行纵向研究。 为了实现K23的目标，Meruelo博士组建了一个专业的多学科团队。 Tapert博士 布朗将促进指导并访问NCANDA数据的活动，以解决一个 NIAAA的主要举措。他们还将提供青春期酒精使用和合并的专业知识 抑郁，计划，招募和实施与青少年的纵向研究设计， 以及对负责任的研究的职业和心态。 Schuckit博士将提供专业知识 关于酒精与抑郁症之间的合并症以及其他职业发展技巧。托马斯·威尔博士 提供有关相关数据的高级纵向分析的培训。 K23研究的特定目的是确定青少年之间的因果关系是否存在 使用潜在差异分数模型的饮酒和长期抑郁症来区分因果 （目标1）。压力和随后的抑郁和/或物质使用的共同因素对于 了解他们对成长中的青少年的影响。第二个（目标2）试图识别形态计量学 这可以预测健康青少年抑郁的发展：（a）幼稚的贝叶斯分类器， （b）主成分分析，随后的层次线性回归。必要的 NCANDA数据可以开始解决该提案的主要问题。以后的其他数据 在K23奖励期内已有数年的时间，并已将其纳入分析中。 行政补充剂将为研究员提供桥梁资金，以协助额外的投资 需要完成目标1和2的完成，并受到我儿子的诞生和covid-19的大流行的破坏，并且 加强我成为独立调查员的道路上的赠款申请。

项目成果

Adolescent Cerebellar Development: An Underexplored Frontier.

青少年小脑发育：一个尚未开发的前沿。

• DOI: 10.1016/j.biopsych.2019.12.024
• 发表时间: 2020
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Meruelo,AlejandroD

Pre-enlistment Anger Attacks and Postenlistment Mental Disorders and Suicidality Among US Army Soldiers.

• DOI: 10.1001/jamanetworkopen.2021.26626
• 发表时间: 2021-09-01
• 期刊: JAMA network open
• 影响因子: 13.8
• 作者: Smith DM;Meruelo A;Campbell-Sills L;Sun X;Kessler RC;Ursano RJ;Jain S;Stein MB;Army STARRS Team
• 通讯作者: Army STARRS Team