Adolescent Markers of Depression and the Impact of Alcohol Use

项目摘要 这个K23奖将使Meruelo博士成为青少年之间关系的专家。 酗酒和抑郁症在培训期间，他建议解决未经治疗的酒精使用问题， 失调和抑郁导致健康状况不佳，最终影响生活质量和数量。 博士Meruelo计划使用创新的方法和多种成像技术的国家 酒精和青少年神经发育联盟（NCANDA），在一项纵向研究中， 大脑特征，解决这两个共病疾病之间的时间关系。识别 风险因素对于预测哪些人将从早期受益至关重要 直接降低发病率和死亡率的干预和治疗。该奖项将为他提供 需要支持发展四个领域的专门知识：（1）青少年酗酒和严重抑郁症，（2） 神经影像学和大脑发育，（3）高级统计学，（4）纵向研究的执行。 为了实现K23的目标，Meruelo博士组建了一个多学科专家团队。泰普特博士 和布朗将促进指导和访问的活动和NCANDA的数据，解决了一个 NIAA的主要举措。他们还将提供青少年饮酒和共病方面的专业知识 抑郁症和规划，招募和实施纵向研究设计与青少年， 以及职业生涯和指导负责任的研究行为。Schuckit博士将提供专业知识 酒精和抑郁症的共病关系以及其他职业发展技能。托马斯医生会 提供相关数据高级纵向分析方面的培训。 K23研究的具体目标是确定青少年之间的因果关系是否 使用潜在差异评分模型区分因果关系的酒精使用和长期抑郁症 (Aim 1）。压力和随后的抑郁症和/或物质使用的共同因素是关键， 了解他们对成长中的青少年的影响。第二个（目标2）旨在确定形态计量学 预测健康青少年抑郁症的发展：（a）朴素贝叶斯分类器， 以及（B）主成分分析和随后的分层线性回归。必要的 NCANDA数据可用于开始解决提案的核心问题。后来的数据 在K23授标期间，已经获得了2000年的数据，并正在纳入分析。 行政补助金将为一名研究员提供过桥资金，以协助进行更多的调查 我需要完成目标1和目标2，但由于我儿子的出生和COVID-19大流行， 在我成为独立调查员的道路上加强我的拨款申请。

PROJECT SUMMARY This K23 award will allow Dr. Meruelo to become an expert on the relationship between adolescent alcohol use and depression. During his training, he proposes to address that untreated alcohol use disorder and depression lead to poor health outcomes ultimately affecting both quality and quantity of life. Dr. Meruelo plans to use an innovative approach and multiple imaging techniques of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA), in a longitudinal study to identify brain features that address the temporal relationship between these two comorbid disorders. Identifying risk factors is of critical importance to anticipating which individuals would benefit from earlier interventions and treatment to reduce morbidity and mortality directly. The award will provide him the support needed to develop expertise in four areas: (1) adolescent alcohol use and major depression, (2) neuroimaging and brain development, (3) advanced statistics, and (4) execution of longitudinal studies. To achieve the K23's goals, Dr. Meruelo has assembled an expert multidisciplinary team. Drs Tapert and Brown will facilitate guidance and access to the activities of and NCANDA data that addresses one of NIAAA's major initiatives. They will also provide expertise in adolescent alcohol use and comorbid depression and on planning, recruiting, and implementing longitudinal study designs with adolescents, as well as career and mentorship on the responsible conduct of research. Dr. Schuckit will provide expertise on comorbidity between alcohol and depression and other career development skills. Dr. Thomas will provide training in advanced longitudinal analyses of associated data. The K23 research specific aims are to identify whether the causal relationships between adolescent alcohol use and long-term depression using latent difference score models to distinguish cause and effect (Aim 1). The common factor of stress and subsequent depression and/or substance use is critical to understanding their impact on growing adolescents. The second (Aim 2) seeks to identify morphometrics that predict the development of depression in healthy adolescents using: (a) Naïve Bayesian classifier, and (b) principal component analysis with subsequent hierarchical linear regression. The necessary NCANDA data is available to begin addressing central questions of the proposal. Additional data from later years have become available during the K23 award period and is being incorporated into the analysis. An administrative supplement will provide bridge funding for a fellow to assist with additional investigations needed to complete Aims 1 and 2, disrupted by the birth of my son and the COVID-19 pandemic, and strengthen my grant applications in my path to becoming an independent investigator.