Adolescent Markers of Depression and the Impact of Alcohol Use

青少年抑郁症的标志和饮酒的影响

• 批准号: 10434067
• 负责人: Alejandro Daniel Meruelo
• 金额: $ 20.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434067
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Alcohol consumption; Alcohols; Amygdaloid structure; Anisotropy; Anterior; Area; Award; Basal Ganglia; Bilateral; Brain; Brain imaging; Cerebellum; Characteristics; Classification; Classification Scheme; Clinical; Computational Biology; Corpus Callosum; Corpus striatum structure; DSM-V; Data; Depressed mood; Development; Diffusion Magnetic Resonance Imaging; Disease; Early Intervention; Early treatment; Exhibits; Fiber; Fusiform gyrus; Goals; Health; Health system; Heavy Drinking; Hippocampus (Brain); Image; Imaging Techniques; Individual; Inferior; Lead; Left; Life; Linear Regressions; Link; Long-Term Depression; Longitudinal Studies; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Medial; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentorship; Metabolic; Modeling; Monitor; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Occipital lobe; Outcome; Participant; Patient Self-Report; Patients; Play; Positioning Attribute; Principal Component Analysis; Process; Quality of life; Reporting; Research; Research Design; Risk; Risk Factors; Role; Running; Sampling; Societies; Stress; Surface; Symptoms; Teenagers; Testing; Thalamic structure; Thick; Time; Training; Youth; alcohol comorbidity; alcohol use disorder; base; brain magnetic resonance imaging; career; career development; child depression; cingulate cortex; clinically significant; comorbid depression; comorbidity; corpus callosum body; cost; depressive symptoms; design; drinking; follow-up; frontal lobe; gray matter; improved; innovation; lateral ventricle; longitudinal analysis; morphometry; mortality; multidisciplinary; neurodevelopment; neuroimaging; recruit; relating to nervous system; responsible research conduct; skill acquisition; statistics; substance use; symptomatology; thalamocortical tract; underage drinking; white matter

PROJECT SUMMARY This K23 award will allow Dr. Meruelo to become an expert on the relationship between adolescent alcohol use and depression. During his training, he proposes to address that untreated alcohol use disorder and depression lead to poor health outcomes ultimately affecting both quality and quantity of life. Dr. Meruelo plans to use an innovative approach and multiple imaging techniques of the NCANDA consortium in a longitudinal study to identify brain features that address the temporal relationship between these two comorbid disorders. Identifying risk factors is of critical importance to anticipating which individuals would benefit from earlier interventions and treatment to reduce morbidity and mortality directly. The award will provide him the support needed to develop expertise in four areas: (1) adolescent alcohol use and major depression, (2) neuroimaging and brain development, (3) advanced statistics, and (4) execution of longitudinal studies. To achieve the K23's goals, Dr. Meruelo has assembled an expert multidisciplinary team. Drs Tapert and Brown will facilitate guidance and access to the activities of and data from a longitudinal study conducted by the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) to address one of NIAAA's major initiatives. They will also provide expertise in adolescent alcohol use and comorbid depression and on planning, recruiting, and implementing longitudinal study designs with adolescents, as well as career and mentorship on the responsible conduct of research. Dr. Schuckit will provide expertise on comorbidity between alcohol and depression and other career development skills. Dr. Thomas will provide hands-on training in advanced longitudinal analyses of associated data. NCANDA data is already available to begin addressing central questions of the proposal. At Year 1 or 2, clinically significant depression has been identified in 61 participants after a healthy prior year following a non- depressed baseline. Also identified are those using moderate or heavy alcohol use at baseline, year 1, and year 2 of the study in 164, 223 and 283 participants, respectively. Year 3 data will be available January 2018. The K23 research specific aims are: (Aim 1) to identify whether any adolescent alcohol use is more likely to lead to long-term depression, or if long-term depression is seen more often after subsequent increases in alcohol use, or both, using latent difference score models to distinguish cause and effect. The common factor of stress and subsequent depression and/or substance use is critical to understanding their impact on growing adolescents, and (Aim 2) to identify morphometrics that predict the development of depression in healthy adolescents using: (a) Naïve Bayesian classifier, and (b) principal component analysis with subsequent hierarchical linear regression.

项目总结 这一K23奖项将使梅鲁埃洛博士成为青少年与青少年之间关系的专家 酗酒和抑郁。在他的培训期间，他建议解决这种未经治疗的酒精使用问题 紊乱和抑郁会导致不良的健康结果，最终影响生活的质量和数量。 梅鲁埃洛博士计划使用一种创新的方法和NCANDA的多种成像技术 联合进行了一项纵向研究，以确定解决时间关系的大脑特征 在这两种共病障碍之间。识别风险因素对于预测至关重要 哪些人将从早期干预和治疗中受益，以减少发病率和死亡率 直接去吧。该奖项将为他提供在四个领域发展专业知识所需的支持：(1)青少年 酒精使用和严重抑郁，(2)神经成像和大脑发育，(3)高级统计，以及 (4)开展纵向研究。 为了实现K23的S目标，梅鲁埃洛博士组建了一支多学科的专家团队。DRS磁带 布朗将促进对纵向研究的活动和数据的指导和访问 由 全国青少年酒精与神经发育联合会(NCANDA) 解决NIAAA的一项主要倡议。他们还将提供青少年酒精使用方面的专业知识和 关于计划、招募和实施纵向研究设计 青少年，以及对负责任的研究行为的职业和指导。舒基特博士将 提供酒精和抑郁症共病方面的专业知识和其他职业发展技能。 托马斯博士将提供相关数据的高级纵向分析方面的实践培训。 NCANDA的数据已经可以开始解决该提案的核心问题。在第一年或第二年， 在61名参与者中发现了具有临床意义的抑郁症，他们在经历了一年的健康生活后， 低迷的基线。同时确定的是那些在基线、第一年和第二年使用中度或重度酒精的人。 研究的第二年分别有164名、223名和283名参与者。第3年数据将于2018年1月提供。 K23研究的具体目标是：(目标1)确定青少年是否更多地饮酒 可能导致长期抑郁，或者如果长期抑郁在随后的 酒精使用量的增加，或两者兼而有之，使用潜在差异得分模型来区分因果关系。 压力和随之而来的抑郁和/或药物使用的共同因素对 了解它们对成长中的青少年的影响，以及(目标2)确定预测青少年发育的形态计量学 使用(A)朴素贝叶斯分类器和(B)主成分的健康青少年中抑郁的发展 用随后的分层线性回归进行成分分析。