PREVENTION OF CHRONIC ASTHMA IN YOUNG CHILDREN

预防幼儿慢性哮喘

• 批准号: 2005675
• 负责人: Mary D. Klinnert
• 金额: $ 42.58万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2005675
• 关键词: airborne allergen; antiinflammatory agents; asthma; case history; child behavior; clinical research; disease /disorder prevention /control; health care cost /financing; health care service utilization; home health care; human subject; immunoglobulin E; infant human (0-1 year); low socioeconomic status; maternal behavior; middle childhood (6-11); nursing intervention; preschool child (1-5); quality of life; respiratory infections

DESCRIPTION: The goal of this five year research demonstration and education project is to determine if an intensive intervention using nurse home visitors can reduce asthma prevalence among children from low income households who begin wheezing in infancy. One hundred eighty infants and their parents who are Medicaid-eligible will be recruited from public health settings. About half of the children will be from minority families. Families will be randomly assigned to a nurse home visitor intervention group or a control group. In the intervention group, nurse home visitors will work with parents for one year to target allergens in the home, reduce environmental tobacco smoke, and improve the quality of maternal caregiving, particularly as it relates to asthma prevention and management. A control group will receive information related to preventing asthma. Repeated assessments of the targeted variables will be made in both groups. In addition, family history of asthma and children's IgE levels at enrollment will be assessed, since these variables are expected to interact with the targeted variables to affect outcome. Maternal psychological resources also will be assessed, as this factor has been associated with responsivity to home visitor interventions. Respiratory infections and use of anti-inflammatory medications will be monitored as possible mediating variables. All children will be followed to 4 years of age. Outcomes to be measured include asthma status, functional severity of asthma by maternal report and by cumulative symptom reports, pulmonary functions and IgE levels, quality of life and child behavioral adjustment, and health care use and costs. The principal investigator is Mary Klinnert, Ph.D., who is Chief of Pediatric Psychology at the National Jewish Center for Immunology and Respiratory Medicine and Associate Professor of Psychiatry at the University of Colorado Health Sciences Center. Co-investigators are Lanny Rosenwasser, M.D., Larry Borish, M.D., and Andy Liu, M.D.

描述：这项五年研究示范的目标和 教育项目是为了确定是否使用护士进行强化干预 家访可以降低低收入儿童的哮喘患病率 在婴儿期就开始喘息的家庭。180名婴儿和 符合医疗补助条件的父母将从公共卫生部门招募 设置。大约一半的孩子将来自少数族裔家庭。 家庭将被随机分配到一名护士家访干预 组或对照组。在干预组中，护理家访 将与父母合作一年，针对家庭中的过敏原，减少 环境烟草烟雾，并提高产妇护理质量， 尤其是在涉及哮喘预防和管理的情况下。A控件 小组将收到与预防哮喘有关的信息。重复 两组都将对目标变量进行评估。在……里面 此外，哮喘家族史和儿童入学时的IgE水平 将被评估，因为这些变量预计将与 影响结果的有针对性的变量。母性心理资源也 将被评估，因为这一因素已与对 家访干预。呼吸道感染和使用 抗炎药物将作为可能的中介药物进行监测 变量。所有儿童将被跟踪到4岁。结果将是 所测量的包括哮喘状态、哮喘的功能严重程度 并根据累积症状报告、肺功能和免疫球蛋白E 水平、生活质量和儿童行为调整，以及卫生保健使用 和成本。 首席调查员是Mary Klinnert博士，她是 国家犹太人免疫中心的儿科心理学 呼吸医学和大学精神病学副教授 科罗拉多州健康科学中心的。联合调查员是兰尼·罗森瓦瑟， M.D.、Larry Borish，M.D.和Andy Liu，M.D.