NONLINEAR MECHANISMS FOR EMF EFFECTS ON CELLS

EMF 对细胞影响的非线性机制

• 批准号: 2019333
• 负责人: RAYMOND Dean ASTUMIAN
• 金额: $ 7.65万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-15 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2019333
• 关键词: biological models; cells; electric field; electromagnetic radiation; magnetic field; mathematical model; model design /development; radiation dosage; radiobiology; tissue /cell culture

DESCRIPTION: The stated goal is to: (1) further develop the formal analogy between occurrence of a biological effect, and measurement of an EMF by the biological system; and (2) to then investigate several classes of biophysical mechanisms. There will be a focus on the change in the number of molecules in a biochemical pathway that arises because of EMF exposure. Another aim is to estimate threshold EMF exposure conditions based on field strength, exposure time and properties of the biological system. Specifically, a one variable and a two variable model for non-linear biochemical reactions will be investigated. To treat stochastic effects, both models will be analyzed by numerical solution of a so-called "master equation".

描述：所陈述的目标是：（1）进一步发展形式类比 在生物效应的发生和由电磁场测量仪测量EMF之间， 生物系统;（2）然后研究几类 生物物理机制 数字的变化会有一个重点 在一个生化途径中的分子，这是由于电磁场暴露而产生的。 另一个目的是基于场估计阈值EMF暴露条件， 强度、暴露时间和生物系统的性质。 具体地，一个变量和两个变量的非线性模型， 将研究生物化学反应。 为了处理随机效应， 这两种模型都将通过所谓的“主模型”的数值解来分析 方程”。