Physical Regulation of Skeletal Repair Workshop

骨骼修复工作坊的物理调节

• 批准号: 6669785
• 负责人: Roy K Aaron
• 金额: $ 1.8万
• 依托单位: AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-04 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6669785
• 关键词: biological signal transduction; biophysics; gene environment interaction; gene expression; meeting /conference /symposium; musculoskeletal regeneration; travel

DESCRIPTION (provided by applicant): It is now evident that skeletal tissues are highly responsive to the physical demands of their environment and respond to changes in physical requirements by altering the synthesis and organization of the extra cellular matrix. This process involves recognition of physical signals, signal transduction, and regulation of gene expression for both structural and signaling proteins. These observations have major implications for, (a.) general considerations of how epigenetic physical factors influence gene expression, (b.) how physical environmental demands result in the clinical observations of atrophy and hypertrophy and, (c.) how manipulation of the physical environment can be utilized therapeutically to stimulate repair. The workshop will explore biophysical agents and related technologies for their relevance to the repair of cartilage and bone. This information will be approached from clinical, physiological, and cellular perspectives with an emphasis on comparisons of mechanisms of action. The format is designed to be both interdisciplinary and highly participatory, fostering exchanges of information and resulting in a consensus on the state of the art and future research directions. The format will present an integrated approach to physical regulation and, for the first time, directly make mechanistic comparisons among a number of physical modalities. The workshop will consider how cells perceive their physical environment, how information about the environment is carried to cells in the form of signal content, how cells transduce this information and how physical stimuli alter gene expression. Emphasis will be placed upon the up-regulation of growth factor synthesis by physical agents as a possible intermediary mechanism of action. Finally, how repairing skeletal tissues organize physical information to augment the repair process, and what translational opportunities exist, will be considered.

描述（由申请人提供）： 现在很明显，骨骼组织对其环境的物理需求具有高度响应性，并通过改变细胞外基质的合成和组织来响应物理需求的变化。这一过程涉及物理信号的识别、信号转导以及结构蛋白和信号蛋白的基因表达调控。这些观察结果有重大影响，（a）。表观遗传物理因素如何影响基因表达的一般考虑，（B.）物理环境需求如何导致萎缩和肥大的临床观察，以及（c.）如何操纵物理环境可以在治疗上用来刺激修复。研讨会将探讨生物物理制剂和相关技术与软骨和骨修复的相关性。这些信息将从临床，生理和细胞的角度来处理，重点是作用机制的比较。这种形式的目的是跨学科和高度参与，促进信息交流，并导致对最先进的和未来的研究方向的共识。该格式将提出一种综合的物理调节方法，并首次直接对一些物理模式进行机械比较。该研讨会将考虑细胞如何感知其物理环境，有关环境的信息如何以信号内容的形式传递给细胞，细胞如何识别这些信息以及物理刺激如何改变基因表达。重点将放在上调生长因子合成的物理代理作为一个可能的中介机制的行动。最后，如何修复骨骼组织组织的物理信息，以增强修复过程中，以及存在什么翻译的机会，将被考虑。