Tissue Engineering in Musculoskeletal Clinical Practice

肌肉骨骼临床实践中的组织工程

• 批准号: 6574605
• 负责人: LINDA J SANDELL
• 金额: $ 2万
• 依托单位: AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-16 至 2003-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6574605
• 关键词: health care professional practice; information dissemination; meeting /conference /symposium; musculoskeletal disorder therapy; musculoskeletal system; organ; orthopedics; technology /technique; tissue engineering; travel

DESCRIPTION (provided by applicant): In the last ten years, there has been intense interest both from the public sector and medical profession in the possibility that the new field of tissue engineering will provide a biological solution to the critical clinical need for organs and tissues. This need is particularly evident in the rebuilding of the skeletal elements of the face and body where the enormous prevalence and societal costs of musculoskeletal disorders underscores the value of clinical application of new methodologies. Research scientists from the disciplines of molecular biology, bioengineering, and materials science have put great effort into designing potential products using cells, growth factors and DNA alone or in structural scaffoldings to recreate functional tissues. Clinicians, primarily in the surgical practices of orthopaedics, plastics and dental surgery are deeply involved in translating this basic research to the patient. The goal of this workshop, and subsequent publication, is to bring to the clinical field the advances that have been made in the field of musculoskeletal tissue engineering as it relates to clinical practice. The specific aims of the workshop are to: 1. Define the scope of the need for orthopaedic-related tissue engineered products. 2. Review and discuss current clinical studies and clinical trials on musculoskeletal tissue engineered products 3. Define the "state of the art" in the specific areas of interest: cartilage, bone and tendon/ligament. 4. Define needs and opportunities for applications of advanced research to clinical practice. 5. Identify future needs that will arise when translating research to the clinical setting. 6. Provide education to the musculoskeletal community and practicing physician in the form of an immediate publication via the Internet. 7. Provide on-going Clinical Studies and Trials information update to musculoskeletal community and the practicing physician via the Internet. The 3.5 day workshop co-sponsored by the American Academy of Orthopaedic Surgeons to be held January 16-19, 2003, will achieve these aims by informational lectures on issues relating to producing a tissue engineered product (To the Market) and the application to clinical practice (To the Clinic). In addition, sessions will be held on the individual areas of tissue engineering most likely to be used in clinical practice in the next few years, that is, cartilage, bone, tendon and ligament. Lastly, worldwide current and future clinical trials will be discussed.

描述（由申请人提供）： 在过去的十年中，公共部门和医疗界都有强烈的兴趣，因为新的组织工程领域将为器官和组织的关键临床需求提供生物学解决方案。在重建面部和身体的骨骼元素的重建中，这种需求尤为明显，在这种骨骼和身体的骨骼元素中，肌肉骨骼疾病的巨大患病率和社会成本强调了新方法的临床应用的价值。来自分子生物学，生物工程和材料科学学科的研究科学家已经为使用细胞，生长因子和单独或结构性脚手架中的DNA设计潜在的产品付出了巨大的努力，以重新创建功能组织。临床医生主要是在骨科，塑料和牙科手术的手术实践中，深入参与将这项基础研究转化为患者。 该研讨会的目的以及随后的出版物是将与临床实践有关的肌肉骨骼组织工程领域取得的进步带入临床领域。研讨会的具体目的是： 1。定义对与骨相关的组织工程产品的需求范围。 2。审查并讨论有关肌肉骨骼组织工程产品的当前临床研究和临床试验 3。定义特定感兴趣领域的“最新技术”：软骨，骨骼和肌腱/韧带。 4。定义了将高级研究应用于临床实践的需求和机会。 5。确定将研究转化为临床环境时会产生的未来需求。 6.以互联网立即出版的形式向肌肉骨骼社区和执业医师提供教育。 7.通过互联网向肌肉骨骼社区和执业医师提供持续的临床研究和试验信息更新。 由美国骨科医师学院共同赞助的3.5天研讨会将于2003年1月16日至19日举行，将通过有关与生产组织工程产品（向市场）和临床实践应用有关的问题（临床）（临床）应用的问题来实现这些目标。此外，在未来几年，即软骨，骨，肌腱和韧带的临床实践中，将在组织工程的各个领域举行会议。最后，将讨论全球当前和未来的临床试验。