ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPE

自适应光学扫描激光检眼镜

• 批准号: 6518707
• 负责人: Austin Roorda
• 金额: $ 18.44万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518707
• 关键词: clinical research; diagnosis design /evaluation; human subject; lasers; ophthalmoscopy; optics; retina disorder; visual photoreceptor

DESCRIPTION: In healthy normal subjects, the primary resolution limiting factors to retinal fundus imaging are the aberrations caused by the eyes' own optics. The applicant was among a team of investigators at the University of Rochester that first demonstrated that these aberrations could be measured with a Shack Hartman wavefront sensor and cancelled using a deformable mirror in a process called adaptive optics (AO). The applicant has now obtained funding from the NSF, University of Houston and Pharmacia and Upjohn to develop a similar device. This device would be incorporated into a scanning laser ophthalmoscope (SLO) rather than the more conventional fundus camera design used in Rochester. This SLO design has the potential to greatly decrease the effects of scattered light and further increase the resolution of fundus imaging.

说明： 在健康的正常人中，视网膜的主要分辨率限制因素 眼底成像是由眼睛自身的光学引起的像差。这个 申请人是罗切斯特大学一组调查人员中的一员 第一次证明了这些像差可以用棚屋测量 哈特曼波前传感器和用可变形反射镜消除的一个过程 被称为自适应光学(AO)。申请人现已获得 NSF、休斯顿大学和法玛西亚大学以及厄普约翰将开发类似的 设备。该设备将被集成到扫描激光检眼镜中 (SLO)，而不是罗切斯特使用的更传统的眼底相机设计。 这种SLO设计有可能极大地减少散布的影响 并且进一步提高了眼底成像的分辨率。