Mechanisms of PKCepsilon-dependent regulation of beta-cell lipid metabolism and insulin secretion
Mechanisms of PKCepsilon-dependent regulation of beta-cell lipid metabolism and insulin secretion
批准号:
nhmrc : 1009189
负责人:
Prof Trevor Biden
金额:
$37.07万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Lipid loading of the insulin-producing beta cells of the pancreas contributes to the onset of Type 2 diabetes, but the mechanisms are poorly understood. We have recently established that inhibiting the enzyme PKCe helps restore insulin secretion. By better defining the cellular role of PKCe we will clarify how insulin secretion is disrupted by fatty acids and cholesterol.
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会议论文
Role of macrophages in lipotoxic beta cell failure
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批准号:nhmrc : 1070662
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项目类别:Project Grants
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资助金额:$40.86万
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负责人:Prof Trevor Biden
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依托单位:
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Research Fellowship
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批准号:nhmrc : 1024961
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项目类别:Research Fellowships
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资助金额:$45.06万
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负责人:Prof Trevor Biden
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依托单位:
Ceramide metabolism and ER stress in fatty-acid mediated destruction of pancreatic beta cells
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批准号:nhmrc : 596828
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项目类别:NHMRC Project Grants
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财政年份:2010
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负责人:Prof Trevor Biden
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依托单位:
Inhibition of glucose-stimulated insulin secretion by Protein Kinase C epsilon
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批准号:nhmrc : 481340
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项目类别:NHMRC Project Grants
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负责人:Prof Trevor Biden
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依托单位:
Research Fellowship - Grant ID:427610
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资助金额:$41.26万
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依托单位:
Alterations in secretion and gene expression in pancreatic beta cells exposed to lipid.
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依托单位:
Muscarinic receptor signalling in the control of insulin secretion
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负责人:Prof Trevor Biden
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 188814
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项目类别:NHMRC Research Fellowships
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资助金额:$37.21万
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负责人:Prof Trevor Biden
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依托单位:
国内基金
海外基金
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批准号:--
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依托单位:
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批准号:31170722
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项目类别:面上项目
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负责人:刘定干
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依托单位: