Muscarinic receptor signalling in the control of insulin secretion

控制胰岛素分泌的毒蕈碱受体信号传导

• 批准号: nhmrc : 230852
• 负责人: Prof Trevor Biden
• 金额: $ 28.36万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/muscarinic-receptor-signalling-insulin-secretion/101303
• 关键词: Muscarinic; receptor; signalling; control; insulin

The project is aimed at a better understanding of the way in which nerves control the release of insulin from the pancreatic beta cells of the islets of Langerhans. Nerves release chemicals called neurotransmitters, one of which, acetylcholine, stimulates insulin release in conjunction with a rise in blood glucose immediately after a meal. Acetylcholine binds to receptors on the surface of the beta cells, and triggers signalling pathways inside the cell. We have discovered novel features of those signalling pathways and plan to explore them further. These include a novel route of generation of the intracellular sigalling compound, diacylglycerol, insights into the way that the intracellular messenger Ca2+ enters the cell, and a better understanding of the way in which enzymes known as protein kinases act.

该项目旨在更好地了解神经控制朗格汉斯胰岛的胰岛β细胞释放胰岛素的方式。神经释放一种名为神经递质的化学物质，其中一种，乙酰胆碱，在餐后立即刺激胰岛素释放和血糖升高。乙酰胆碱与β细胞表面的受体结合，并触发细胞内的信号通路。我们已经发现了这些信号通路的新特征，并计划进一步探索它们。这些包括一种产生细胞内信号化合物二酰甘油的新途径，对细胞内信使钙离子进入细胞的方式的洞察，以及对被称为蛋白激酶的酶的作用方式的更好理解。