Inhibition of glucose-stimulated insulin secretion by Protein Kinase C epsilon

蛋白激酶 C epsilon 抑制葡萄糖刺激的胰岛素分泌

• 批准号: nhmrc : 481340
• 负责人: Prof Trevor Biden
• 金额: $ 37.05万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-glucose-stimulated-c-epsilon/99066
• 关键词: Inhibition; glucose; stimulated; insulin; secretion

Type 2 diabetes is a chronic disease which occurs when the pancreas is unable to produce enough insulin for the body to cope with rising blood glucose levels after a meal, and is strongly linked to obesity. We have discovered that fat oversupply activates an enzyme in the pancreas causing defects in insulin release due to glucose. Inhibiting this enzyme helps overcome diabetes, through poorly defined mechanisms that we aim to clarify here. Our work could lead to new therapies for diabetes.

2型糖尿病是一种慢性疾病，当胰腺无法产生足够的胰岛素供身体科普餐后血糖水平升高时发生，并且与肥胖密切相关。我们已经发现，脂肪过量会激活胰腺中的一种酶，导致葡萄糖导致胰岛素释放缺陷。抑制这种酶有助于克服糖尿病，通过不明确的机制，我们的目的是澄清这里。我们的工作可能会导致糖尿病的新疗法。