Role of lysosomal acid lipase in regulating insulin secretion

溶酶体酸性脂肪酶在调节胰岛素分泌中的作用

• 批准号: nhmrc : 1051658
• 负责人: Prof Trevor Biden
• 金额: $ 38.07万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-lysosomal-acid-insulin-secretion/112230
• 关键词: Role; lysosomal; acid; lipase; regulating

Type 2 diabetes (T2D) affects 7% of Australians and is a major cause of morbidity and mortality. A failure of insulin secretion contributes to T2D, and this is linked to the inability of insulin producing ?-cells to use lipids appropriately (lipotoxicity). Here we will study the role of a cellular body called the lysosome to regulate ?-cell lipid metabolism and insulin secretion. This work will greatly increase the understanding of ?-cell failure in T2D.

2型糖尿病（T2 D）影响7%的澳大利亚人，是发病率和死亡率的主要原因。胰岛素分泌的失败有助于T2 D，这与胰岛素产生的能力有关。细胞适当使用脂质（脂毒性）。在这里，我们将研究的作用，一个细胞体称为溶酶体调节？-细胞脂质代谢和胰岛素分泌。这项工作将大大增加了解？- 2型糖尿病的细胞衰竭