REGIONAL FLOW MEASUREMENTS IN TUMORS

描述（由申请人提供）：为了使肿瘤生长，它必须从宿主那里获得营养和氧气，并不断进化新的脉管系统，为其增殖的细胞提供供应。利用血管生成抑制剂和改变肿瘤血流的血管活性化合物来减少或逆转肿瘤恶性生长的干预研究令人兴奋。通过使用可视化和量化肿瘤血管特性的仪器和方法，可以推进这一重要领域的研究。该项目涉及开发一种仪器，用于测量实验动物肿瘤的区域血流和血管结构，并生成这些重要肿瘤特征的高分辨率三维分布图。该仪器将为癌症研究实验室提供一种工具，用于在肿瘤发展和治疗的各个阶段量化这些特性。特异分析软件显示和量化肿瘤区域血流和血管结构。随着项目的进展，合作研究人员将提供仪器和软件功能的反馈。该仪器将通过增加实验数据的数量和质量，减少评估癌症治疗的成本和时间，推进有前途的癌症研究。

DESCRIPTION (provided by applicant): In order for a tumor to grow, it must obtain nutrients and oxygen from its host and continuously evolve new vasculature to deliver supplies to its multiplying cells. Exciting current research studies of interventions that reduce or reverse malignant growth of tumors using angiogenesis inhibitors and vasoactive compounds that modify tumor blood flow. Research in this important area can be advanced by access to instruments and methods that visualize and quantify properties of tumor vasculature. This project involves the development of an instrument to measure both regional blood flow and vascular structure in tumors from experimental animals and produce high-resolution, three-dimensional distribution maps of these important tumor characteristics. The instrument will provide cancer research laboratories with a tool for quantifying these properties at various stages of tumor development and treatment. The specific analysis software to display and quantify tumor regional flow and vascular structure. Collaborating researchers will provide feedback on instrument and software functionality as the project progresses. This instrumentation will advance promising cancer research by increasing the quantity and quality of experimental data and reducing cost and time to evaluate cancer treatments.