REGIONAL FLOW MEASUREMENTS IN TUMORS

描述（由申请人提供）：为了使肿瘤生长，它必须从其宿主获得营养物质和氧气，并不断进化新的血管系统以向其增殖细胞提供供应。 令人兴奋的当前研究干预，减少或逆转肿瘤的恶性生长，使用血管生成抑制剂和血管活性化合物，修改肿瘤血流。 这一重要领域的研究可以通过获得可视化和量化肿瘤血管特性的仪器和方法来推进。 该项目涉及开发一种仪器，用于测量实验动物肿瘤中的局部血流和血管结构，并生成这些重要肿瘤特征的高分辨率三维分布图。 该仪器将为癌症研究实验室提供一种在肿瘤发展和治疗的各个阶段量化这些特性的工具。 该分析软件能够显示和量化肿瘤区域血流和血管结构。 随着项目的进展，合作研究人员将提供有关仪器和软件功能的反馈。 这种仪器将通过增加实验数据的数量和质量，减少评估癌症治疗的成本和时间，推动有前途的癌症研究。

DESCRIPTION (provided by applicant): In order for a tumor to grow, it must obtain nutrients and oxygen from its host and continuously evolve new vasculature to deliver supplies to its multiplying cells. Exciting current research studies of interventions that reduce or reverse malignant growth of tumors using angiogenesis inhibitors and vasoactive compounds that modify tumor blood flow. Research in this important area can be advanced by access to instruments and methods that visualize and quantify properties of tumor vasculature. This project involves the development of an instrument to measure both regional blood flow and vascular structure in tumors from experimental animals and produce high-resolution, three-dimensional distribution maps of these important tumor characteristics. The instrument will provide cancer research laboratories with a tool for quantifying these properties at various stages of tumor development and treatment. The specific analysis software to display and quantify tumor regional flow and vascular structure. Collaborating researchers will provide feedback on instrument and software functionality as the project progresses. This instrumentation will advance promising cancer research by increasing the quantity and quality of experimental data and reducing cost and time to evaluate cancer treatments.