Research Project 2 Molecular, viral and genetic epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest risk for HIV infection
研究项目 2 影响艾滋病毒感染风险最高的阿根廷人口的病毒引起的艾滋病定义癌症的分子、病毒和遗传流行病学
基本信息
- 批准号:10488070
- 负责人:
- 金额:$ 13.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-20 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS related cancerAIDS/HIV problemAcquired Immunodeficiency SyndromeAcyclovirAddressAffectAnimal ModelAnti-Retroviral AgentsAnusAreaArgentinaArgentineAwardBasic ScienceBiologicalBlood specimenCD4 Lymphocyte CountCancer BurdenCaringCell LineCellsCharacteristicsChlamydiaClinicalClinical DataCohort StudiesCollaborationsCollectionCommunitiesCoupledCytologyDNA Virus InfectionsDevelopmentDiagnosisDiseaseDrug usageEnrollmentEpidemiologyFundingGene ExpressionGeneral PopulationGenesGenetic DeterminismGenetic studyGenomicsGoalsHIVHIV InfectionsHIV SeronegativityHIV SeropositivityHealthHealth Services AccessibilityHealth systemHigh PrevalenceHormonesHospitalsHumanHuman Herpesvirus 8Human PapillomavirusHuman papilloma virus infectionIn VitroIncidenceIncomeIndividualInfectionInternationalInterventionKaposi SarcomaKnowledgeLesionLife ExpectancyLocationLongitudinal StudiesMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of anusModelingMolecularMolecular AbnormalityMolecular EpidemiologyMolecular GeneticsMonitorMutationNorth AmericaOncogenicOralPathologicPatientsPeripheral Blood Mononuclear CellPersonsPharmaceutical PreparationsPoliciesPopulationPortraitsPositioning AttributePrevalenceProspective cohortReduce health disparitiesRegistriesResearchResearch PersonnelResearch PriorityResearch Project GrantsResearch SupportResearch TrainingRisk FactorsSamplingSerologySiteSouth AmericaSpecimenSubgroupSyphilisTestingTimeTissue SampleTreatment outcomeTumor TissueUnited States National Institutes of HealthVariantViralViral EpidemiologyViral Load resultViral hepatitisViremiaVirusVirus DiseasesWorkadvocacy organizationsbasecancer riskcareerco-infectioncohortcomorbiditydriver mutationexome sequencinggenetic epidemiologyhigh riskhigh risk populationimprovedin vivolow and middle-income countriesmenneoplasticpremalignantprospectiverepositoryresearch clinical testingsexsocial structuretranscriptometranscriptome sequencingtranscriptomicstransgendertransgender womentranssexualtransvestitetreatment disparitytreatment responsetumorworking group
项目摘要
RESEARCH PROJECT 2 SUMMARY
JULY 2017-JUNE 2023
Men having sex with men (MSM) and transgender women (TGW) are the most affected populations by HIV,
present high prevalence of KSHV and HPV, and two malignant conditions associated to these virus (Kaposi
Sarcoma and Anal Squamous Cell Carcinoma, respectively)
are also disproportionally affecting these groups.
KS continues being the most important AIDS associated cancer in LMICs. On the other hand, ART changed the
course of HIV and increased life expectancy, but HPV persistence represents a continued risk factor for anal
cancer.
The aims of this project are 1) to increase the knowledge about prevalence, incidence, and clearance of KSHV
and HR-HPV among high risk individuals (MSM and TG individuals with and without HIV) and factors associated
to clinical progression 2) to create a repository of prospective and retrospective samples of KS and ASCC cou-
pled to clinical data and 3) to explore in KS and ASCC the molecular portrait and viral factors by Whole-Exome
sequencing in parallel with RNA-Seq profiling comparing the mutational and gene expression profiles of samples
for identify specific transcriptome.
We will accomplish these aims studying two populations: a) a cohort of individuals at high risk of developing KS
and ASCC 220 MSM and 110 transgender women, HIV positive and HIV negative) in whom we will assess every
6 months during 4 years the prevalence, incidence, and associated factors for KSHV infection and HPV infection.
c) a repository of clinical information and biological samples of individual with KS and ASCC. This registry will
involve two components, the prospective component that will collect clinical data and samples from patients in
study for KS or ASCC (15-30/year) and a retrospective component aimed to provide limited clinical information
and remnants of pathological specimens at 6 sites (400 KS and 200 ASCC). All the material will be available
also for Basic and Translational Projects 1 and 2.
With these aims our research contributes to several areas defined by NIH as high priority research on HIV/AIDS,
including the focus in malignances, basic research on genetic determinants of co-morbidities and research to
reduce health disparities in the treatment outcomes of people living with HIV. Further, this research will support
research capacity development in a low- and middle-income settings. Accordingly, we aim to address several
urgent health questions, which will inform the development of a range of policies and interventions throughout
South and North America. The long-term objective of this study is to catalyze international collaboration among
US and Argentinean investigators to improve capacity to reduce the cancer burden among HIV individuals.
研究项目2总结
2017年7月-2023年6月
男男性行为者(MSM)和变性妇女(TGW)是受艾滋病毒影响最严重的人群,
目前KSHV和HPV的高流行率,以及与这些病毒相关的两种恶性疾病(Kaposi
分别为肉瘤和肛门鳞状细胞癌)
也会对这些群体产生不良影响。
KS仍然是中低收入国家中最重要的艾滋病相关癌症。另一方面,艺术改变了
艾滋病毒的过程和预期寿命的增加,但HPV的持续存在是肛门炎的持续危险因素,
癌
本项目的目的是:1)增加对KSHV流行、发病和清除的认识
高危人群(MSM和TG个体,有和没有HIV)中HR-HPV和相关因素
2)建立KS和ASCC患者的前瞻性和回顾性样本库,
结合临床资料; 3)应用全外显子组技术探讨KS和ASCC的分子特征和病毒因素
测序与RNA-Seq分析并行,比较样品的突变和基因表达谱
用于鉴定特异性转录组。
我们将通过研究两个人群来实现这些目标:a)一组具有发展KS高风险的个体
和ASCC 220男男性接触者和110变性妇女,艾滋病毒阳性和阴性),我们将评估每一个
4年中6个月KSHV感染和HPV感染的患病率、发病率及相关因素。
c)患有KS和ASCC的个体的临床信息和生物样品的储存库。本登记册将
涉及两个部分,前瞻性部分将收集临床数据和患者样本,
KS或ASCC研究(15-30/年)和旨在提供有限临床信息的回顾性部分
6个部位(400 KS和200 ASCC)的病理标本残留。所有的材料都将提供
也适用于基础和翻译项目1和2。
有了这些目标,我们的研究有助于NIH定义为艾滋病毒/艾滋病高优先级研究的几个领域,
包括以恶性肿瘤为重点,对并发症的遗传决定因素进行基础研究,
减少艾滋病毒感染者在治疗结果方面的健康差距。此外,这项研究将支持
在低收入和中等收入环境中发展研究能力。因此,我们的目标是解决几个
紧急的健康问题,这将为制定一系列政策和干预措施提供信息,
南美洲和北美洲。这项研究的长期目标是促进国际合作,
美国和阿根廷的研究人员,以提高能力,减少艾滋病毒感染者的癌症负担。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Pedro Enrique Cahn其他文献
Pedro Enrique Cahn的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Pedro Enrique Cahn', 18)}}的其他基金
Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)
加勒比、中南美洲艾滋病毒流行病学网络 (CCASAnet)
- 批准号:
10089682 - 财政年份:2020
- 资助金额:
$ 13.07万 - 项目类别:
Research Project 2 Molecular, viral and genetic epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest risk for HIV infection
研究项目 2 影响艾滋病毒感染风险最高的阿根廷人口的病毒引起的艾滋病定义癌症的分子、病毒和遗传流行病学
- 批准号:
10246319 - 财政年份:2017
- 资助金额:
$ 13.07万 - 项目类别:
BIOMARKER DISCOVERY FOR TUBERCULOSIS INFECTION AND DISEASE
结核病感染和疾病的生物标志物发现
- 批准号:
8957817 - 财政年份:2015
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASAnet)
- 批准号:
9113206 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central and South America network for HIV epidemiology (CCASnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASnet)
- 批准号:
8189047 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASAnet)
- 批准号:
10241647 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central and South America network for HIV epidemiology (CCASnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASnet)
- 批准号:
8711188 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASAnet)
- 批准号:
10415216 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central and South America network for HIV epidemiology (CCASnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASnet)
- 批准号:
8306676 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别:
Caribbean, Central and South America network for HIV epidemiology (CCASnet)
加勒比、中美洲和南美洲艾滋病毒流行病学网络 (CCASnet)
- 批准号:
8510546 - 财政年份:2006
- 资助金额:
$ 13.07万 - 项目类别: