Technology Core

全球健康的营养、感染和癌症护理点技术(征兆) 3.0技术核心 摘要 征兆技术核心描述了我们推进前景看好的全球健康相关的流程 针对感染、癌症和营养的点护理技术，有助于提高临床生存能力。我们在此描述 (1)我们从美国、我们的临床合作伙伴以及世界各地征集和选择新项目的流程 世界，(2)我们的年度需求评估共识将如何从根本上指导这一进程，(3)如何 我们将通过我们的合作伙伴网络支持团队建设，(4)临床核心将如何实现部署 和确认选定的技术，以及(5)传播核心将如何支持：商业化 通过全球卫生实验室到市场的加速器、项目参与者的培训和成果的传播。 为了最大限度地利用我们可以部署的资源，全力以赴将重点支持6-7个并行 超出概念验证阶段并将从临床验证中受益的项目已经 经过验证或甚至在国内商业化，但正在寻求扩展到国际环境，或已经 由我们的国际合作伙伴开发/孵化，并显示出满足美国市场需求的前景。 为了说明我们将在整个工作中提供的资金，我们提供了四个PoC项目建议书，这些建议书源于 康奈尔、哥伦比亚、马萨诸塞州总医院和圣约翰斯研究所(印度) 打算在第一年提供资金。这些项目满足了我们最初的需求中定义的特定需求 评估共识，包括宫颈癌的早期筛查，全面确定 铁状态使贫血筛查、艾滋病毒联合检测和性传播多路检测成为可能 疾病，以及更广泛、更便宜和更准确的疟疾检测。这些团队中的每一个都将与 我们至少有一个临床站点来验证他们的技术，我们的传播核心来培训用户工作人员 并让开发人员参与临床轮换。在第一年之后，将向各地征集新的和继续的 我们广为传播的RFP，并根据一系列预定义的标准进行选择，其中包括：适合 需求评估共识、技术准备情况、里程碑、对能力建设的贡献，以及 项目团队。到第五年年底，我们预计我们将启动20个独立的护理点 技术项目，其中30%将来自美国以外，80%将过渡到更大的 融资机会、许可安排或初创公司。

Point of Care Technologies for Nutrition, Infection and Cancer for Global Health (PORTENT) 3.0 Technical Core Abstract The PORTENT Technical core describes our process for advancing promising global health relevant point-of-care technologies for infection, cancer and nutrition towards clinical viability. We describe herein (1) our process for soliciting and selecting new projects from the US, our clinical partners, and from around the world, (2) how that process will be fundamentally guided by our annual needs assessment consensus, (3) how we will support team building through our partnership network, (4) how the clinical core will enable deployment and validation of the selected technologies, and (5) how the dissemination core will support: commercialization through the global health lab-to-market accelerator, training of project participants, and dissemination of results. To take maximum advantage of the resources we can deploy, at full capacity will focus on supporting 6-7 parallel projects that either are beyond the proof-of-concept stage and would benefit from clinical validation, have been validated or even commercialized domestically but are looking to expand to international settings, or have been developed/incubated by our international partners and show promise at addressing a market need in the US. Illustrative of what we will fund throughout the effort we provide four PoC project proposals originating from Cornell, Columbia, Massachusetts General Hospital, and the St. Johns Research Institute (India) that we intend to fund in year 1. These projects address specific needs which are defined in our initial needs assessment consensus and include early screening of cervical cancer, comprehensive determination of iron status enabling anemia screening, combined HIV and multiplexed detection of sexually transmitted diseases, and broader, cheaper, and more accurate malaria testing. Each of these teams will partner with at least one of our clinical sites to validate of their technologies and our dissemination core to train users workers and engage developers in clinical rotations. Beyond year 1, new and continuing will be solicited from around the world with our broadly disseminated RFP and selected based on a series pre-defined criteria which include: fit with needs assessment consensus, technological readiness, milestones, contribution to capacity building, and project team. By the end of year 5 we anticipate that we will initiate 20 independent point of care technology projects, of which 30% will originate from outside the US and 80% will transition to a larger funding opportunity, licensing arrangement or start-up company.