Paper-COVID - Platform for High-throughput SARS-CoV-2 Screening and Contact Tracing
Paper-COVID - Platform for High-throughput SARS-CoV-2 Screening and Contact Tracing
批准号:
10196383
负责人:
David Carl Erickson
金额:
$43.2万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-05 至 2024-07-31
关键词:
2019-nCoVAirBiological AssayCOVID-19COVID-19 pandemicCOVID-19 screeningCOVID-19 testCOVID-19 testingCar PhoneClinicClinicalComputer softwareContact TracingContractsDevelopmentDiagnosticDiagnostic testsElementsEngineeringFDA Emergency Use AuthorizationGoalsGovernmentHealthIndividualInfrastructureInstitutesInstitutionInstitutional Review BoardsInternationalJointsLaboratoriesLearningLengthMediatingMedicalMedicineMethodsNatureNew York CityNormalcyPaperPatientsPhasePoint-of-Care SystemsProcessPublic HealthReportingResearchRiskRunningSamplingSiteSocietiesSymptomsSystemTechniquesTechnologyTemperatureTestingTimeTravelUniversitiesValidationWorkWorkplaceauthoritybasecoronavirus diseasecostdetection platformdiagnostic platformhandheld mobile devicehigh throughput screeningisothermal amplificationmeetingsnovelpandemic diseasepoint of carepoint of care testingportabilityprototypesaliva samplesample collectionscreening
中文摘要
摘要
目前,大多数COVID-19的诊断检测都是通过当地对那些
出现症状后进行集中实验室检测-3-4天内返回结果。这一点现在得到了补充
通过几个即时护理(Point-of-Care,简称POS)系统,这些系统可以在现场执行相同的测试,更快地返回结果,
但吞吐量低得多。为了使美国经济的许多要素恢复到更接近正常的功能,
作为国际航空旅行,大规模的雇主,和校园为基础的高等院校,将需要我们
从诊断性检测转向大规模、分布式和重复筛查无症状(或预
症状)个体。传统的集中式测试的时间长度和相对较低的
现有的RFID系统的吞吐量将使这成为一个挑战。
在这里,我们建议开发Paper-COVID -一个模块化平台,结合临床验证的LAMP检测
(已获得FDA EUA批准),并采用基于移动的手机的纸张测试平台,
无症状SARS-CoV-2的通量筛查,并促进自动化接触者追踪。我们的目标是
努力验证一种新的样品处理技术,将以前开发的LAMP检测方法移植到纸上,
的格式,构建了三个模块化的原型系统,并验证它对临床样本从纽约
市
英文摘要
Abstract
At present, most of the diagnostic testing for COVID-19 has been done through local sampling of those who are
symptomatic followed by centralized laboratory testing – returning results in 3-4 days. This is now supplemented
by several point-of-care (PoC) systems who can perform the same test on site, returning the result much quicker,
but at much lower throughput. To return many elements of the US economy to closer to normal function, such
as international air travel, large-scale employers, and campus-based institutes of higher learning, will require us
to shift from diagnostic testing to large scale, distributed, and repeated screening of asymptomatic (or pre-
symptomatic) individuals. The length of time-to-result for traditional centralized testing and the relatively low
throughput of existing PoC systems will make this a challenge.
Here we propose to develop Paper-COVID – a modular platform that combines a clinically validated LAMP assay
(already with FDA EUA approval) with a mobile phone based paper testing platform that enables much higher
throughput screening for asymptomatic SARS-CoV-2 and facilitates automated contact tracing. The goal for this
effort is to validate a novel sample processing technique, port the previously developed LAMP assay to a paper-
based format, construct three modular prototype systems, and validate it on clinical samples from New York
City.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.3390/genes13101914
发表时间:
2022-10-21
期刊:
Genes
影响因子:
3.5
作者:
[]
通讯作者:
Point of Care Technologies for Nutrition, Infection, and Cancer for Global Health (PORTENT)
-
批准号:10714506
-
项目类别:
-
资助金额:$160.64万
-
财政年份:2023
-
负责人:David Carl Erickson
-
依托单位:
Point of Care Technologies for Nutrition, Infection, and Cancer for Global Health (PORTENT)
-
批准号:10714507
-
项目类别:
-
资助金额:$24.61万
-
财政年份:2023
-
负责人:David Carl Erickson
-
依托单位:
Artificial Intelligence and Precision Nutrition Training Program
-
批准号:10752485
-
项目类别:
-
资助金额:$32.44万
-
财政年份:2023
-
负责人:David Carl Erickson
-
依托单位:
Technology Core
-
批准号:10714508
-
项目类别:
-
资助金额:$68.04万
-
财政年份:2023
-
负责人:David Carl Erickson
-
依托单位:
Development of a Point of Care Multiplexed Diagnostic Platform to Target Anemia and Micronutrient Deficiencies
-
批准号:9542788
-
项目类别:
-
资助金额:$11.39万
-
财政年份:2017
-
负责人:David Carl Erickson
-
依托单位:
Early Stage Diagnosis of Kaposi's Sarcoma in Limited Resource Settings using KS-Detect
-
批准号:9334145
-
项目类别:
-
资助金额:$49.9万
-
财政年份:2016
-
负责人:David Carl Erickson
-
依托单位:
FeverPhone: Point of Care Diagnosis of Acute Febrile Illness using a Mobile Device
-
批准号:9008392
-
项目类别:
-
资助金额:$61.16万
-
财政年份:2016
-
负责人:David Carl Erickson
-
依托单位:
Early Stage Diagnosis of Kaposi's Sarcoma in Limited Resource Settings using KS-Detect
-
批准号:9031275
-
项目类别:
-
资助金额:$50.0万
-
财政年份:2016
-
负责人:David Carl Erickson
-
依托单位:
Early Stage Diagnosis of Kaposi's Sarcoma in Limited Resource Settings using KS-Detect
-
批准号:10018466
-
项目类别:
-
资助金额:$90.68万
-
财政年份:2016
-
负责人:David Carl Erickson
-
依托单位:
FeverPhone: Point of Care Diagnosis of Acute Febrile Illness using a Mobile Device
-
批准号:9301546
-
项目类别:
-
资助金额:$60.03万
-
财政年份:2016
-
负责人:David Carl Erickson
-
依托单位:
A New Approach to Autonomous Point-of-care Tropical Disease Diagnostics Using Sol
-
批准号:8609568
-
项目类别:
-
资助金额:$17.45万
-
财政年份:2013
-
负责人:David Carl Erickson
-
依托单位:
A New Approach to Autonomous Point-of-care Tropical Disease Diagnostics Using Sol
-
批准号:8443640
-
项目类别:
-
资助金额:$21.9万
-
财政年份:2013
-
负责人:David Carl Erickson
-
依托单位:
Single Molecule Optically Resonant NanoTweezers for the study of Intracellular Me
-
批准号:8601119
-
项目类别:
-
资助金额:$28.92万
-
财政年份:2013
-
负责人:David Carl Erickson
-
依托单位:
KS-Detect: A sample-in, answer-out solution to the Diagnosis of Kaposi's Sarcoma
-
批准号:8780631
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2013
-
负责人:David Carl Erickson
-
依托单位:
Single Molecule Optically Resonant NanoTweezers for the study of Intracellular Me
-
批准号:8419345
-
项目类别:
-
资助金额:$27.65万
-
财政年份:2013
-
负责人:David Carl Erickson
-
依托单位:
KS-Detect: A sample-in, answer-out solution to the Diagnosis of Kaposi's Sarcoma
-
批准号:8636238
-
项目类别:
-
资助金额:$23.28万
-
财政年份:2013
-
负责人:David Carl Erickson
-
依托单位:
Optically Resonant Nanotweezers
-
批准号:8069193
-
项目类别:
-
资助金额:$17.82万
-
财政年份:2010
-
负责人:David Carl Erickson
-
依托单位:
Optically Resonant Nanotweezers
-
批准号:7896973
-
项目类别:
-
资助金额:$22.47万
-
财政年份:2010
-
负责人:David Carl Erickson
-
依托单位:
Nanoscale Optofluidic Pathogen Detection
-
批准号:7847743
-
项目类别:
-
资助金额:$0.78万
-
财政年份:2007
-
负责人:David Carl Erickson
-
依托单位:
Nanoscale Optofluidic Pathogen Detection
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批准号:7640877
-
项目类别:
-
资助金额:$18.04万
-
财政年份:2007
-
负责人:David Carl Erickson
-
依托单位:
国内基金
海外基金
湍流和化学交互作用对H2-Air-H2O微混燃烧中NO生成的影响研究
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批准号:51976048
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项目类别:面上项目
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资助金额:61.0万元
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批准年份:2019
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负责人:邱朋华
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依托单位: