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Infant diet and cardiometabolic risk among children born preterm

Infant diet and cardiometabolic risk among children born preterm
早产儿的婴儿饮食和心脏代谢风险
批准号:
10716587
负责人:
Mandy Brown Belfort
金额:
$75.31万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-08-23 至 2028-07-31

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英文摘要
Project Summary / Abstract Each year, over 63,000 U.S. infants are born very preterm, prior to 32 weeks of gestation. With >90% now surviving to discharge due to better obstetrical and neonatal intensive care unit (NICU) management, the present challenge is to reduce short- and long-term morbidities experienced by survivors, including the two- to four-fold increased risk of obesity, diabetes, hypertension, and metabolic syndrome that manifest by young adulthood. The Developmental Origins of Health and Disease (DOHaD) framework posits that chronic conditions result from adverse exposures during vulnerable developmental stages known as “critical” or “sensitive” periods. Of particular importance is the first 1000 days of life, when key developmental processes set the stage for lifelong health. Very preterm infants are an especially vulnerable population, as they require NICU support for 2-4 months after birth, coinciding with the 3rd trimester – an established sensitive period for programming of obesity and cardiometabolic risk. In this context, the most highly modifiable and relevant exposure is diet during the NICU hospitalization, which may contribute to the accelerated accretion of fat mass relative to fat-free mass. Hospitalized very preterm infants typically experience impaired weight gain, stunted linear growth, and excess fat accretion relative to the typical fetus. To offset these issues and support brain development, dietary fortification of human milk is provided as standard of care. However, the consequences of dietary fortification for cardiometabolic health in this population are poorly understood. This proposal seeks to uncover the extent to which diet-based interventions that promote physical growth and brain development during a sensitive period may also contribute to cardiometabolic risk. We will study 130 infants born 24-31 weeks of gestation who are participating in the Nourish Study (R01HD097327l; PI: Belfort), an ongoing randomized controlled trial testing the effect of individually targeted human milk fortification vs. standard of care during the NICU hospitalization. By extending follow-up of this cohort and adding cardiometabolic biomarkers at 2 and 5 years of age, we have a unique opportunity to investigate how macronutrient and energy delivery during a sensitive period contributes to, or protects from, cardiometabolic risk during childhood. We are further poised to address key questions about NICU growth patterns in relation to cardiometabolic health in this population. Findings from this work have strong potential to impact clinical care by informing dietary strategies during a sensitive window in development to optimize lifelong health for a vulnerable population.
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Development of a brain-specific nutritional status indicator for very preterm infants
  • 批准号:
    10597868
  • 项目类别:
  • 资助金额:
    $75.63万
  • 财政年份:
    2022
  • 负责人:
    Mandy Brown Belfort
  • 依托单位:
Development of a brain-specific nutritional status indicator for very preterm infants
  • 批准号:
    10710198
  • 项目类别:
  • 资助金额:
    $68.46万
  • 财政年份:
    2022
  • 负责人:
    Mandy Brown Belfort
  • 依托单位:
Targeting human milk fortification to improve preterm infant growth and brain development
  • 批准号:
    10459586
  • 项目类别:
  • 资助金额:
    $74.13万
  • 财政年份:
    2019
  • 负责人:
    Mandy Brown Belfort
  • 依托单位:
Targeting human milk fortification to improve preterm infant growth and brain development
  • 批准号:
    10247537
  • 项目类别:
  • 资助金额:
    $74.54万
  • 财政年份:
    2019
  • 负责人:
    Mandy Brown Belfort
  • 依托单位:
海外基金