Bulk Dry Heat Sterilizer in Zeigler Building at UAB

UAB 齐格勒大楼的散装干热灭菌器

• 批准号: 10716008
• 负责人: DAVID C SCHWEBEL
• 金额: $ 35万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10716008
• 关键词: Administrator; Aging; Alabama; Animal Behavior; Animal Experimentation; Animals; Award; Back; Biomedical Research; Cancer Survivor; Cardiac health; Cartilage; Chinchilla (genus); Cilia; Complex; Consumption; Data; Dedications; Development; Disease; Dryness; Elevator; Employee; Ensure; Environment; Epigenetic Process; Equipment; Equity; Faculty; Ferrets; Floor; Fructose; Funding; Funding Agency; Goals; Grant; Growth; Health; Heart; Human; Hygiene; Impact evaluation; Infrastructure; Laboratories; Logistics; Maintenance; Measurement; Memory; Memory Disorders; Modernization; Molecular; Mus; Muscular Dystrophies; Nervous System Physiology; Pathology; Pharmaceutical Preparations; Principal Investigator; Proteins; Rana; Rattus; Reporting; Reproducibility; Request for Proposals; Research; Research Infrastructure; Research Personnel; Risk; Risk Reduction; Role; Sample Size; Sanitation; Science; Scientific Advances and Accomplishments; Scientist; Services; Site; Soil; Steam; Sterilization; System; Technology; Training; United States National Institutes of Health; Universities; Water; animal colony; animal resource; cardiovascular health; chemobrain; drug development; energy efficiency; experience; healing; improved; innovation; interest; member; operation; pathogen; prevent; programs; research facility; risk mitigation; shift work

Bulk Dry Heat Sterilizer in Zeigler Building at UAB UAB (University of Alabama at Birmingham) has experienced rapid research growth and currently ranks among the top 25 universities nationally in NIH funding. This proposal requests funding to purchase a bulk dry heat sterilizer to serve the vivarium in the Zeigler Building, located in the heart of UAB’s biomedical research campus. Serving the 71 animal researchers based in the Zeigler vivarium, it will enable point-of-use sterilization and mitigate risk of contamination to pre-sterilized caging transported by truck from a different campus building. The equipment will create a modernized, green, and more rigorous research environment for the science conducted in Zeigler, UAB’s second-largest vivarium, plus the countless research programs we expect to be based in Zeigler in the decades to come. UAB uses 3 centralized cage-wash facilities to serve 12 campus vivariums. This strategy offers efficient logistics to clean and sterilize large volumes of soiled cages but impacts scientific rigor because sterilized cages are transported by truck from a cage-wash and steam-powered autoclave facility in a different building back to Zeigler. The purchase of this sterilizer will mitigate contamination risk from that transport, modernize facilities and meet sustainability goals. The scientific innovation occurring in Zeigler’s vivarium is wide-ranging and impressive. Quantitatively, the sterilizer will serve 71 Principal Investigators from 17 academic departments, 58 of them NIH-funded with >$28M in awards in the current fiscal year. The vivarium houses about 4500 cages, mostly mice and rats but also including ferrets, frogs, and chinchillas. Examples of pioneering science occurring in the vivarium include efforts to treat muscular dystrophy, prevent “chemobrain”, understand the effect of high fructose corn syrup on neurological functioning, examine epigenetic effects on memory, determine whether shiftwork impacts cardiovascular health, and develop drugs to heal cartilage. Long-term maintenance of the equipment will be managed by UAB’s Animal Resources Program and overseen by an external oversight board. Operation will be conducted by trained Animal Resources Program staff. In summary, the proposed bulk heat sterilizer will support the scientific needs of UAB’s large and growing research portfolio, offer substantial modernization of UAB’s equipment, and provide a green- technology solution consistent with UAB’s sustainability goals.

UAB Zeigler大楼的散装干热灭菌器 UAB（亚拉巴马大学伯明翰分校）经历了快速的研究增长，目前排名 在全国NIH资助的前25名大学中。该提案要求提供资金，以购买散装干货 热灭菌器，以服务于齐格勒大楼，位于UAB的生物医学研究的心脏动物园 校园为齐格勒动物园的71名动物研究人员服务， 通过卡车从不同地点运输预灭菌笼具， 校园建筑该设备将为科研人员创造一个现代化的、绿色的、更加严格的科研环境， 在UAB第二大动物园Zeigler进行的科学研究，加上我们无数的研究项目， 预计在未来几十年内将以齐格勒为基地。 UAB使用3个集中的笼子清洗设施，为12个校园动物园提供服务。这一战略提供了有效的 物流清洁和消毒大量污染的笼子，但影响科学严谨性，因为消毒 笼由卡车从不同建筑物中的笼清洗和蒸汽动力高压灭菌设施运输 回到齐格勒。购买该灭菌器将减轻运输、现代化 设施，实现可持续发展目标。 在齐格勒的动物园中发生的科学创新是广泛的和令人印象深刻的。从数量上讲， 该消毒器将为来自17个学术部门的71名主要研究人员提供服务，其中58名由NIH资助， > 2800万美元的奖励在本财政年度。动物园有大约4500个笼子，大部分是老鼠和老鼠， 也包括雪貂青蛙和龙猫在动物园中发生的开创性科学的例子包括 努力治疗肌肉萎缩症，防止“chemobrain”，了解高果糖玉米糖浆对 神经功能，检查对记忆的表观遗传影响，确定轮班工作是否影响 心血管健康，并开发药物来治疗软骨。 设备的长期维护将由UAB的动物资源计划管理， 由外部监督委员会监督。操作将由经过培训的动物资源计划进行 工作人员 总之，建议的散装热灭菌器将支持UAB的大型和 不断增长的研究组合，提供UAB的设备的实质性现代化，并提供一个绿色- 符合UAB可持续发展目标的技术解决方案。