Bulk Dry Heat Sterilizer in Zeigler Building at UAB

UAB 齐格勒大楼的散装干热灭菌器

• 批准号: 10716008
• 负责人: DAVID C SCHWEBEL
• 金额: $ 35万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10716008
• 关键词: Administrator; Aging; Alabama; Animal Behavior; Animal Experimentation; Animals; Award; Back; Biomedical Research; Cancer Survivor; Cardiac health; Cartilage; Chinchilla (genus); Cilia; Complex; Consumption; Data; Dedications; Development; Disease; Dryness; Elevator; Employee; Ensure; Environment; Epigenetic Process; Equipment; Equity; Faculty; Ferrets; Floor; Fructose; Funding; Funding Agency; Goals; Grant; Growth; Health; Heart; Human; Hygiene; Impact evaluation; Infrastructure; Laboratories; Logistics; Maintenance; Measurement; Memory; Memory Disorders; Modernization; Molecular; Mus; Muscular Dystrophies; Nervous System Physiology; Pathology; Pharmaceutical Preparations; Principal Investigator; Proteins; Rana; Rattus; Reporting; Reproducibility; Request for Proposals; Research; Research Infrastructure; Research Personnel; Risk; Risk Reduction; Role; Sample Size; Sanitation; Science; Scientific Advances and Accomplishments; Scientist; Services; Site; Soil; Steam; Sterilization; System; Technology; Training; United States National Institutes of Health; Universities; Water; animal colony; animal resource; cardiovascular health; chemobrain; drug development; energy efficiency; experience; healing; improved; innovation; interest; member; operation; pathogen; prevent; programs; research facility; risk mitigation; shift work

Bulk Dry Heat Sterilizer in Zeigler Building at UAB UAB (University of Alabama at Birmingham) has experienced rapid research growth and currently ranks among the top 25 universities nationally in NIH funding. This proposal requests funding to purchase a bulk dry heat sterilizer to serve the vivarium in the Zeigler Building, located in the heart of UAB’s biomedical research campus. Serving the 71 animal researchers based in the Zeigler vivarium, it will enable point-of-use sterilization and mitigate risk of contamination to pre-sterilized caging transported by truck from a different campus building. The equipment will create a modernized, green, and more rigorous research environment for the science conducted in Zeigler, UAB’s second-largest vivarium, plus the countless research programs we expect to be based in Zeigler in the decades to come. UAB uses 3 centralized cage-wash facilities to serve 12 campus vivariums. This strategy offers efficient logistics to clean and sterilize large volumes of soiled cages but impacts scientific rigor because sterilized cages are transported by truck from a cage-wash and steam-powered autoclave facility in a different building back to Zeigler. The purchase of this sterilizer will mitigate contamination risk from that transport, modernize facilities and meet sustainability goals. The scientific innovation occurring in Zeigler’s vivarium is wide-ranging and impressive. Quantitatively, the sterilizer will serve 71 Principal Investigators from 17 academic departments, 58 of them NIH-funded with >$28M in awards in the current fiscal year. The vivarium houses about 4500 cages, mostly mice and rats but also including ferrets, frogs, and chinchillas. Examples of pioneering science occurring in the vivarium include efforts to treat muscular dystrophy, prevent “chemobrain”, understand the effect of high fructose corn syrup on neurological functioning, examine epigenetic effects on memory, determine whether shiftwork impacts cardiovascular health, and develop drugs to heal cartilage. Long-term maintenance of the equipment will be managed by UAB’s Animal Resources Program and overseen by an external oversight board. Operation will be conducted by trained Animal Resources Program staff. In summary, the proposed bulk heat sterilizer will support the scientific needs of UAB’s large and growing research portfolio, offer substantial modernization of UAB’s equipment, and provide a green- technology solution consistent with UAB’s sustainability goals.

UAB 齐格勒大楼的散装干热灭菌器 UAB（阿拉巴马大学伯明翰分校）经历了快速的研究发展，目前排名 跻身 NIH 资助全国前 25 名大学之列。该提案要求提供资金购买散装干货 热灭菌器为位于 UAB 生物医学研究中心的 Zeigler 大楼的动物饲养室提供服务 校园。它将为 Zeigler 动物园的 71 名动物研究人员提供服务，实现使用点 消毒并降低对来自不同国家的卡车运输的预消毒笼具的污染风险 校园建筑。该设备将为科研人员营造现代化、绿色、更加严谨的科研环境 在 UAB 第二大动物园 Zeigler 进行的科学研究，以及我们无数的研究项目 预计在未来几十年内将总部设在齐格勒。 UAB 使用 3 个集中式笼子清洗设施来为 12 个校园动物园提供服务。该策略提供了高效 物流对大量污染的笼子进行清洁和消毒，但由于消毒而影响了科学严谨性 笼子由卡车从另一座建筑物的笼子清洗和蒸汽动力高压灭菌设施运输 回到齐格勒。购买该灭菌器将减轻运输过程中的污染风险，实现现代化 设施并实现可持续发展目标。 齐格勒动物园中发生的科学创新范围广泛且令人印象深刻。从数量上来说， 该灭菌器将为来自 17 个学术部门的 71 名首席研究员提供服务，其中 58 名由 NIH 资助 本财年的奖励金额超过 2800 万美元。动物园里有大约 4500 个笼子，大部分是老鼠，但 还包括雪貂、青蛙和龙猫。动物园中发生的开创性科学的例子包括 努力治疗肌营养不良症，预防“化学脑”，了解高果糖玉米糖浆对肌肉萎缩症的影响 神经功能，检查表观遗传对记忆的影响，确定轮班工作是否会影响 心血管健康，并开发治疗软骨的药物。 设备的长期维护将由 UAB 的动物资源计划和 由外部监督委员会监督。操作将由经过培训的动物资源计划进行 职员。 总之，拟议的大型热灭菌器将支持 UAB 大型和大型实验室的科学需求。 不断增长的研究组合，对 UAB 的设备进行实质性现代化，并提供绿色- 符合 UAB 可持续发展目标的技术解决方案。