Bulk Dry Heat Sterilizer in Zeigler Building at UAB

UAB 齐格勒大楼的散装干热灭菌器

• 批准号: 10716008
• 负责人: DAVID C SCHWEBEL
• 金额: $ 35万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10716008
• 关键词: Administrator; Aging; Alabama; Animal Behavior; Animal Experimentation; Animals; Award; Back; Biomedical Research; Cancer Survivor; Cardiac health; Cartilage; Chinchilla (genus); Cilia; Complex; Consumption; Data; Dedications; Development; Disease; Dryness; Elevator; Employee; Ensure; Environment; Epigenetic Process; Equipment; Equity; Faculty; Ferrets; Floor; Fructose; Funding; Funding Agency; Goals; Grant; Growth; Health; Heart; Human; Hygiene; Impact evaluation; Infrastructure; Laboratories; Logistics; Maintenance; Measurement; Memory; Memory Disorders; Modernization; Molecular; Mus; Muscular Dystrophies; Nervous System Physiology; Pathology; Pharmaceutical Preparations; Principal Investigator; Proteins; Rana; Rattus; Reporting; Reproducibility; Request for Proposals; Research; Research Infrastructure; Research Personnel; Risk; Risk Reduction; Role; Sample Size; Sanitation; Science; Scientific Advances and Accomplishments; Scientist; Services; Site; Soil; Steam; Sterilization; System; Technology; Training; United States National Institutes of Health; Universities; Water; animal colony; animal resource; cardiovascular health; chemobrain; drug development; energy efficiency; experience; healing; improved; innovation; interest; member; operation; pathogen; prevent; programs; research facility; risk mitigation; shift work

Bulk Dry Heat Sterilizer in Zeigler Building at UAB UAB (University of Alabama at Birmingham) has experienced rapid research growth and currently ranks among the top 25 universities nationally in NIH funding. This proposal requests funding to purchase a bulk dry heat sterilizer to serve the vivarium in the Zeigler Building, located in the heart of UAB’s biomedical research campus. Serving the 71 animal researchers based in the Zeigler vivarium, it will enable point-of-use sterilization and mitigate risk of contamination to pre-sterilized caging transported by truck from a different campus building. The equipment will create a modernized, green, and more rigorous research environment for the science conducted in Zeigler, UAB’s second-largest vivarium, plus the countless research programs we expect to be based in Zeigler in the decades to come. UAB uses 3 centralized cage-wash facilities to serve 12 campus vivariums. This strategy offers efficient logistics to clean and sterilize large volumes of soiled cages but impacts scientific rigor because sterilized cages are transported by truck from a cage-wash and steam-powered autoclave facility in a different building back to Zeigler. The purchase of this sterilizer will mitigate contamination risk from that transport, modernize facilities and meet sustainability goals. The scientific innovation occurring in Zeigler’s vivarium is wide-ranging and impressive. Quantitatively, the sterilizer will serve 71 Principal Investigators from 17 academic departments, 58 of them NIH-funded with >$28M in awards in the current fiscal year. The vivarium houses about 4500 cages, mostly mice and rats but also including ferrets, frogs, and chinchillas. Examples of pioneering science occurring in the vivarium include efforts to treat muscular dystrophy, prevent “chemobrain”, understand the effect of high fructose corn syrup on neurological functioning, examine epigenetic effects on memory, determine whether shiftwork impacts cardiovascular health, and develop drugs to heal cartilage. Long-term maintenance of the equipment will be managed by UAB’s Animal Resources Program and overseen by an external oversight board. Operation will be conducted by trained Animal Resources Program staff. In summary, the proposed bulk heat sterilizer will support the scientific needs of UAB’s large and growing research portfolio, offer substantial modernization of UAB’s equipment, and provide a green- technology solution consistent with UAB’s sustainability goals.

UAB齐格勒大楼散装干热灭菌器 阿拉巴马大学伯明翰分校经历了快速的研究增长，目前排名 在NIH资助的全国前25所大学中。这项提案要求提供资金来购买散装干货 位于UAB生物医学研究中心的Zeigler大楼内为外阴提供服务的加热灭菌器 校园里。为齐格勒间隔室的71名动物研究人员提供服务，它将使使用点 用卡车从不同的地方运输预先消毒的笼子，对其进行灭菌并降低污染风险 校园大楼。该设备将为以下方面创造一个现代化、绿色、更严格的研究环境 在UAB第二大隔室齐格勒进行的科学研究，加上我们无数的研究项目 预计在未来几十年将总部设在齐格勒。 UAB使用3个集中式笼式清洗设施为12个校园隔间提供服务。这一策略提供了高效 对大量污染的笼子进行清洁和消毒的物流，但会影响科学严谨性，因为经过灭菌 笼子用卡车从另一栋楼的笼子清洗和蒸汽动力高压灭菌器设施中运输出来 回到齐格勒。购买这种消毒器将减少运输、现代化 设施和实现可持续发展目标。 齐格勒的间隔器中发生的科学创新是广泛和令人印象深刻的。从数量上讲， 该消毒器将为来自17个学术部门的71名首席研究人员提供服务，其中58个由NIH资助 本财年，&gt；的奖金为2800万美元。间隔层容纳了大约4500个笼子，大部分是老鼠和大鼠，但 也包括雪貂、青蛙和龙猫。发生在间隔层的开创性科学的例子包括 努力治疗肌营养不良，防止“化疗”，了解高果糖玉米糖浆对 神经功能，检查表观遗传对记忆的影响，确定轮班工作是否会影响 心血管健康，并开发治疗软骨的药物。 设备的长期维护将由UAB的动物资源计划和 由外部监督委员会监督。手术将由训练有素的动物资源计划进行 工作人员。 总而言之，拟议的散装热灭菌器将支持UAB的大型和 不断增长的研究组合，提供UAB设备的实质性现代化，并提供绿色- 符合UAB可持续发展目标的技术解决方案。