Center of Integrated Biomedical and Bioengineering Research (CIBBR)

综合生物医学与生物工程研究中心（CIBBR）

• 批准号: 10714950
• 负责人: Rick H Cote
• 金额: $ 205.31万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714950
• 关键词: Acceleration; Advisory Committees; Advocate; Area; Award; Biomedical Engineering; Biomedical Research; Businesses; Career Mobility; Centers of Research Excellence; Collaborations; Communication; Computational Biology; Core Facility; Data Science Core; Dedications; Development; Ecosystem; Educational workshop; Effectiveness; Environment; Evaluation; Faculty; Faculty Recruitment; Funding; Goals; Grant; Health; Human; Infrastructure; Institution; Interdisciplinary Study; Investments; Knowledge; Leadership; Measurement; Mentors; Molecular; New Hampshire; Operations Research; Outcome; Performance; Phase; Phenotype; Pilot Projects; Program Development; Program Evaluation; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Science; Services; Technology; Training; Translations; United States National Institutes of Health; Universities; career; career development; clinical development; clinically relevant; diagnostic tool; early-career faculty; effectiveness research; faculty mentor; improved; innovation; instrument; instrumentation; model design; multidisciplinary; multiple omics; operation; programs; recruit; research faculty

PROJECT SUMMARY/ABSTRACT (OVERALL CORE) The University of New Hampshire’s (UNH) first COBRE: Center of Integrated Biomedical and Bioengineering Research (CIBBR) has substantially improved the biomedical and bioengineering research environment during Phase 1. These gains can be attributed to four major advancements: (a) strategic investments in Research Project and Pilot Project funding for 13 early-stage (plus 4 mid-career) UNH faculty conducting biomedical and bioengineering research; (b) dedicated mentoring of these faculty by the CIBBR Leadership Team and External Scientific Mentors; (c) major gains in research infrastructure, including the acquisition of state-of-the-art instrumentation and creation of the Molecular and Cellular Phenotyping Core, and; (d) the amplification of this infrastructure by institutional contributions to new instrumentation and addition of new technical staff within UNH’s University Instrumentation Center. The overall goal of this Phase 2 application is to further advance biomedical and bioengineering research by implementing a faculty “cluster hire” that—together with a new Data Science Core and other enhancements to research infrastructure—will accelerate rigorous, multidisciplinary research at UNH to advance the translation of biomedical discoveries to applied solutions that improve human health. We will accomplish this through the following specific aims: Aim 1. Expand and strengthen our Center’s research, administrative operations, and evaluation programs to further enhance the research environment at UNH for conducting NIH- funded biomedical and bioengineering research. Aim 2. Create a critical mass of NIH-funded investigators through recruitment of early-stage investigators supported by enhanced multi-component mentoring and career development programs for CIBBR investigators. Upon completion of Phase 2 of CIBBR, we will have strategically increased the biomedical research capacity at UNH through “cluster” hiring of both early-stage investigators and senior biomedical and bioengineering researchers and improved and expanded the mentoring of CIBBR faculty. This will be accompanied by the creation of a Data Science Core and acquisition of additional research instrumentation for the Molecular and Cellular Phenotyping Core. These actions will have a powerful and sustained impact on biomedical and bioengineering research at UNH by expanding the number of faculty performing NIH-funded research. Enhancing the capacity of UNH and external researchers to apply multidisciplinary and multi-omics approaches will increase our knowledge of basic biomedical science and bioengineering, expedite the development of clinically relevant diagnostic tools and treatments, and advance biomedical workforce training capacity in the State of NH.

项目摘要/摘要（整体核心） 新罕布什尔大学（UNH）的第一家毛病：综合生物医学中心和 生物工程研究（CIBBR）已大大改善了生物医学和生物工程研究 第1阶段的环境。这些收益可以归因于四个主要进步：（a）策略 用于研究项目和试点项目资金的投资13个早期（加4个职业）UND教师 进行生物医学和生物工程研究； （b）Cibbr对这些教师的敬业 领导团队和外部科学导师； （c）研究基础设施的重大收益，包括 获取最先进的仪器以及分子和细胞表型核心的创建， 和; （d）通过机构对新工具和加法的贡献来扩增本基础设施 UNH大学仪器中心的新技术人员。 该第2阶段应用的总体目标是进一步推进生物医学和生物工程研究 通过实施教师“集群雇用”，该教师与新的数据科学核心和其他增强功能结合 研究基础设施 - 将加速严格的多学科研究，以促进 将生物医学发现的翻译转换为改善人类健康的应用解决方案。我们将实现这一目标 通过以下特定目的：目标1。扩展和加强我们中心的研究，行政 运营和评估计划，以进一步增强UNH的研究环境，以进行NIH- 资助的生物医学和生物工程研究。目标2。创建大量的NIH资助的调查员 通过招募提高多组成指导和职业支持的早期研究人员 CIBBR研究人员的开发计划。 CIBBR的第2阶段完成后，我们将在战略上增加生物医学研究 通过“集群”雇用早期研究人员和高级生物医学和高级生物医学和 生物工程研究人员并改善和扩大了CIBBR教师的心理。这将是 伴随着创建数据科学核心并获得其他研究工具 分子和细胞表型核心。这些行动将对 通过扩大执行NIH资助的教师的数量，在UNH的生物医学和生物工程研究 研究。增强UNH和外部研究人员运用多学科和多派的能力 方法将增加我们对基本生物医学科学和生物工程的了解，加快 开发临床相关的诊断工具和治疗，并提高生物医学劳动力培训 NH状态的能力。

项目成果

Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement.

• DOI: 10.1016/j.bbr.2020.112887
• 发表时间: 2021-01-15
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Hart E;Hertia D;Barrett ST;Charntikov S
• 通讯作者: Charntikov S

Assessment of individual differences in response to acute bupropion or varenicline treatment using a long-access nicotine self-administration model and behavioral economics in female rats.

使用长期尼古丁自我给药模型和雌性大鼠的行为经济学来评估对急性安非他酮或伐尼克兰治疗反应的个体差异。

• DOI: 10.1016/j.bbr.2020.112558
• 发表时间: 2020
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Kazan,Theodore;Robison,ChristopherL;Cova,Nicole;Madore,VictoriaM;Charntikov,Sergios
• 通讯作者: Charntikov,Sergios

Application of Voltage in Dynamic Light Scattering Particle Size Analysis.

电压在动态光散射粒度分析中的应用。

• DOI: 10.3791/60257
• 发表时间: 2020
• 期刊: Journal of visualized experiments : JoVE
• 作者: Ren,Tianyu;Roberge,EmmaJ;Csoros,JohnR;Seitz,WRudolph;Balog,EvaRoseM;Halpern,JeffreyMark
• 通讯作者: Halpern,JeffreyMark

Investigation to Minimize Electrochemical Impedance Spectroscopy Drift.

• DOI: 10.1149/09707.0737ecst
• 发表时间: 2020
• 期刊: ECS transactions
• 作者: Ziino ER;Marnoto S;Halpern JM
• 通讯作者: Halpern JM

Association between inflammation, lipopolysaccharide binding protein, and gut microbiota composition in a New Hampshire Bhutanese refugee population with a high burden of type 2 diabetes.

• DOI: 10.3389/fnut.2022.1059163
• 发表时间: 2022
• 期刊: FRONTIERS IN NUTRITION
• 影响因子: 5
• 作者: Moser, Brandy;Moore, Dustin;Khadka, Bishnu;Lyons, Carrie;Foxall, Tom;Andam, Cheryl P.;Parker, Cooper J.;Ochin, Chinedu;Garelnabi, Mahdi;Sevigny, Joseph;Thomas, W. Kelley;Bigornia, Sherman;Dao, Maria Carlota
• 通讯作者: Dao, Maria Carlota