AREA II CANCER AND AGING
第二领域癌症与衰老
基本信息
- 批准号:7561532
- 负责人:
- 金额:$ 30.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-08-01 至 2008-07-31
- 项目状态:已结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAfrican AmericanAgingAging-Related ProcessAlaska NativeAreaAsiansAutoimmune DiseasesAutoimmunityBiologyBronchogenic CarcinomaCancer Death RatesCaucasiansCaucasoid RaceCell AgingCell CommunicationCell Cycle RegulationCell Differentiation processCell NucleusCellsChemistryCollaborationsColonComplementComputer Retrieval of Information on Scientific Projects DatabaseComputer Systems DevelopmentDeath RateDevelopmentDiagnosisDrosophila genusEventEvolutionFacultyFemaleFundingGene ExpressionGene Expression RegulationGenus ColaGoalsGrantHispanicsHumanHuman Herpesvirus 8ImmuneImmune systemImmunologyIncidenceIndividualInstitutionInterest GroupLungMalignant NeoplasmsMalignant neoplasm of cervix uteriMalignant neoplasm of liverMalignant neoplasm of prostateMemorial Sloan-Kettering Cancer CenterMicrobiologyMinorityMolecularOrganismPacific Island AmericansParticipantPhysicsPilot ProjectsPopulationPositioning AttributeRangeRecruitment ActivityRectal CancerRegulationResearchResearch PersonnelResearch Project GrantsResourcesSignal PathwaySite VisitSourceStomach CarcinomaSubgroupT-LymphocyteTumor BiologyUnited States National Institutes of HealthWomananticancer researchcancer riskcancer typedesireinterestmalignant breast neoplasmmalignant stomach neoplasmmedical schoolsmembermenprogramsstatisticstransmission process
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The original goal of Area II, Gene Expression and Regulation, was to understand the
mechanisms that control gene expression, so that the molecular events that govern cell
differentiation and organism development can be elucidated. There are twelve members of
Area II whose interests are diverse, but overlap to form clusters of common interest. All
but one of these researchers have been hired within the past ten years.
Over the years, the research foci of the various areas has undergone much change due to
the many recent advances in these fields that have, in turn, spurred faculty recruitment in
the departments of physics, biology and chemistry. Because research in gene expression
has diverged into several different foci, Area II has become a somewhat large and
disorganized subgroup (as stated in our last NIH site visit). We separated the
faculty participants into two new Areas. Members of the old AIDS subgroup were re-
organized into an Immunology Subgroup, comprised of Drs. Guyden, Balogh-Nair, Boto,
Coico, Moore together with the more recent hires: Drs. Gottleib, Spatz, and Pezzano (this
will become a new area IV). The goal of Area IV, Immunology, is to understand the cell-
to-cell interactions and molecular mechanisms that control the development and function
of the immune system. Within the group, a smaller subgroup is focused on the
mechanisms that regulate autoimmunity, both at the developmental and regulatory levels.
There are six members of Area IV, consisting of 2 research active faculty from the CUNY
Medical School department of Microbiology and Immunology and 4 from the department
of Biology. William Boto, Shubha Govind and Jerry Guyden were hired through the RCMI
grant directly. Mark Pezzano was recruited for a faculty position in the Biology
department, after serving as Deputy Director of the RCMI program and collaborating on
research projects with Dr. Guyden for several years. Paul Gottlieb and Linda Spatz were
hired by the CUNY Medical School and recruited to join the RCMI program because of their
active research collaboration focused on autoimmunity when the immunology subgroup
was initiated in our last proposal. All of these researchers currently have outside funding
for their research projects and many have collaborative projects both within the group and
with outside investigators. The research interests of the group are diverse, ranging from
studies of innate immune system development and function in Drosophila to KSHV
transmission and evolution in humans. We have several investigators who study aspects
of immune cell development in both B and T cells and immune system regulation, which
are focused on a key question in Immunology as to how the immune system distinguishes
self from non-self. These studies are directly relevant to the development of autoimmune
diseases.
The remaining members of the old Area II will become members of a new subgroup with a
research focus on the development of cancer and aging (Area II). The rationale for forming
a new cancer subgroup within the RCMI is twofold:
1. Disparities in Cancer incidence and treatment is an issue that particularly impacts
minority populations. This point is clearly illustrated by the following statistics taken from
the NCI website [ HYPERLINK "http://www.nci.nih.gov/newscenter/healthdisparities%5D"
http://www.nci.nih.gov/newscenter/healthdisparities] :
-African-Americans have an 8.7% greater incidence of cancer overall, and are 29.1% more
likely to die from it than caucasians.
- African-American women are 21.6% more likely to be diagnosed with colon and rectal
cancers and 5.6% more likely to be diagnosed with lung and bronchial cancers than white
women. African-American women also have an 86.4% higher incidence of breast cancer
than white women and are 32.0% more likely to die from it.
-African-American men are 12.9% more likely to be diagnosed with colon and rectal
cancers than white men and are 51.6% more likely to be diagnosed with lung and
bronchial cancers. Death rates from these cancers are also higher in African-american
men - 37.0% and 36.8% greater death rates than white men for these types of cancers,
respectively.
- African-American men are also 65.6% more likely to be diagnosed with prostate cancer
and 141.7% more likely to die from it than their white counterparts.
- Hispanic women are 82.8% more likely to be diagnosed with cervical cancer and 37.0%
more likely to die from it than caucasian females. Asian/Pacific islanders, American
indians/Alaskan natives, Hispanics and African Americans all have a higher incidence of
liver cancer (187.5%, 22.9%, 89.6%, 43.8% respectively) and stomach cancer (124.7%,
42.9%, 72.7%, 81.8% respectively) than caucasians.
2. There is already significant scientific expertise, and the nucleus for, a cancer group
within area II. Drs. Hubbard and Steinberg currently have ongoing research programs in
cancer research and are collaborators on an NIH-funded pilot project with Dr. Irene Orlow
at the Memorial Sloan Kettering Cancer Center. In addition, Dr. Hubbard wishes to extend
her ongoing research on cell senescence to cancer development as a function of the aging
process. As there is a well established direct relationship between cancer incidence and
aging (summarized in: Ukraintseva, S. and Yashin, A.: Individual Aging and Cancer Risk:
Are They Related? Demographic Research 9:164-195, 2003) it is our desire to hire a new
researcher with interests in cancer and aging that will complement their research as well
as that of other area II faculty with research in related areas such as cell cycle control and
signaling pathways - namely Dr. Govind and the recent hire, Gillian Small. In addition,
through the efforts of Dr. Hubbard, department of biology recruited Mary Alpaugh from
UCLA. She was asked to join the RCMI program because of her exciting project in tumor
biology.
项目成果
期刊论文数量(0)
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MARK L STEINBERG其他文献
MARK L STEINBERG的其他文献
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{{ truncateString('MARK L STEINBERG', 18)}}的其他基金
Activation of the cyclin D1 promoter by arsenite
亚砷酸盐激活细胞周期蛋白 D1 启动子
- 批准号:
8288735 - 财政年份:2009
- 资助金额:
$ 30.09万 - 项目类别:
Activation of the cyclin D1 promoter by arsenite
亚砷酸盐激活细胞周期蛋白 D1 启动子
- 批准号:
7896859 - 财政年份:2009
- 资助金额:
$ 30.09万 - 项目类别:
Activation of the cyclin D1 promoter by arsenite
亚砷酸盐激活细胞周期蛋白 D1 启动子
- 批准号:
7693131 - 财政年份:2009
- 资助金额:
$ 30.09万 - 项目类别:
Activation of the cyclin D1 promoter by arsenite
亚砷酸盐激活细胞周期蛋白 D1 启动子
- 批准号:
8098102 - 财政年份:2009
- 资助金额:
$ 30.09万 - 项目类别:
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