Development and Study of Enzyme Functional Mimics

酶功能模拟物的开发与研究

• 批准号: 7419097
• 负责人: JAMES Patrick MORKEN
• 金额: $ 2.18万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7419097
• 关键词: Alkenes; Biological Assay; Boron; Carbon; Class; Development; Enzymes; Esters; Facility Construction Funding Category; Felis catus; Funding; Hydrogenation; Ligands; Metals; Methods; Modeling; Numbers; Object Attachment; Organic Synthesis; Organometallic Chemistry; Principal Investigator; Process; Production; Range; Reaction; Research; Route; Scheme; Screening procedure; Structure; Temperature; adduct; base; catalyst; design; functional group; functional mimics; improved; novel; programs; propadiene; scaffold

Development of novel metal-catalyzed processes has significant implications for stereoselective organic synthesis and also for our understanding of fundamental organometallic chemistry. When useful new catalytic processes are able to proceed at low catalyst loading, at room temperature and directly on commercially available materials, they can serve as a linchpin for total synthesis efforts and also as an efficient route to the production of basic organic building blocks. Catalytic reactions with these design criteria are the subject of the proposed research. Described within, is a program directed towards introducing a broad range of new and useful catalytic transformations which are the creation of stereogenic carbon-boron bonds. The centerpiece transformation is a catalytic alkene diboration reaction which provides a synthetically versatile vicinal diboron intermediate. In addition to developing this process, we aim to develop the synthetic utility of the diboron adducts such that a rich array of chiral functionalized compounds may be accessed from unsaturated substrates in an asymmetric fashion. Specific Aims are: (1) Develop modular P-N ligand scaffolds and employ them to develop a model for asymmetric induction and to improve reaction scope. (2) Develop complexity-generating reactions based on cascade sequences that involve conversion of C-B bonds to C-X bonds. (3) Develop synthetic methods that are initiated by diboration of prochiral allenes . (4) Develop chiral ligand structures that are effective for the catalytic enantioselective hydrogenation of vinylboronates .

新型金属催化工艺的发展对立体选择有机材料具有重要意义