Steroselective Reductive Condensation Reactions

描述(由申请人提供)：拟议的研究将继续努力开发温和的催化立体选择性方法来形成C-C键。在前一个资金阶段，开发了还原偶联反应，其中C-C键的形成是在使用温和的硅烷还原剂的条件下完成的。我们在这方面的研究已经基本结束，我们已经开始研究在钯催化下形成温和的C-C键的替代方法。我们将开发的钯催化过程将在非常温和的条件下以立体选择性的方式完成C-C键的形成。这里提出的过程将提供基本的手性构建块，这是竞争方法难以获得的。除了开发的方法外，我们还将针对一些具有生物和结构兴趣的天然产品。这些合成努力将有助于挑战新开发的方法的有效性，将突出它们对合成化学家的最终效用，并将提供一个框架来引入新的合成策略。

DESCRIPTION (provided by applicant): The proposed research will continue our efforts in development of mild catalytic stereoselective methods for C-C bond formation. In the preceding funding period, reductive coupling reactions were developed wherein C-C bond formation was accomplished under conditions which use a mild silane reducing agent. Our research in this area has largely concluded and we have begun to examine alternate methods for mild C-C bond formation under palladium catalysis. The palladium catalyzed process which we will develop will accomplish C-C bond formation under extraordinarily mild conditions and in a stereoselective fashion. The processes proposed herein will deliver fundamental chiral building blocks which are difficult to access with competitive methodologies. In addition to the methods developed, we will target a number of biologically and structurally interesting natural products. The synthesis endeavors will serve to challenge the efficacy of newly developed methodologies, will highlight their eventual utility to synthetic chemists, and will provide a framework to introduce new synthesis strategies.