Steroselective Reductive Condensation Reactions

立体选择性还原缩合反应

• 批准号: 7681464
• 负责人: JAMES Patrick MORKEN
• 金额: $ 29.74万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7681464
• 关键词: Alkenes; Area; Base Sequence; Biological Factors; Catalysis; Coupling; Development; Funding; Learning; Methodology; Methods; Organic Synthesis; Oxidation-Reduction; Palladium; Physical condensation; Process; Reaction; Reagent; Reducing Agents; Research; Scheme; Silanes; Structure; interest; silane

DESCRIPTION (provided by applicant): The proposed research will continue our efforts in development of mild catalytic stereoselective methods for C-C bond formation. In the preceding funding period, reductive coupling reactions were developed wherein C-C bond formation was accomplished under conditions which use a mild silane reducing agent. Our research in this area has largely concluded and we have begun to examine alternate methods for mild C-C bond formation under palladium catalysis. The palladium catalyzed process which we will develop will accomplish C-C bond formation under extraordinarily mild conditions and in a stereoselective fashion. The processes proposed herein will deliver fundamental chiral building blocks which are difficult to access with competitive methodologies. In addition to the methods developed, we will target a number of biologically and structurally interesting natural products. The synthesis endeavors will serve to challenge the efficacy of newly developed methodologies, will highlight their eventual utility to synthetic chemists, and will provide a framework to introduce new synthesis strategies.

描述（由申请人提供）：拟议的研究将继续我们的努力，在发展温和的催化立体选择性的方法形成C-C键。在之前的资助期间，开发了还原偶联反应，其中在使用温和的硅烷还原剂的条件下完成C-C键的形成。我们在这一领域的研究已经基本结束，我们已经开始研究在钯催化下形成温和的C-C键的替代方法。我们将开发的钯催化方法将在非常温和的条件下以立体选择性的方式实现C-C键的形成。本文提出的方法将提供难以用竞争性方法获得的基本手性结构单元。除了开发的方法，我们将针对一些生物学和结构上有趣的天然产物。合成的努力将有助于挑战新开发的方法的有效性，将突出其最终效用的合成化学家，并将提供一个框架，介绍新的合成策略。