Genetics and Genomic Approaches to Lung Diseases and Disorders in Washington, DC

描述(由申请人提供)： 我们建议为华盛顿特区地区提供肺部疾病遗传学/基因组学方面的K12培训计划。拟议的K12将被整合到最近成立的华盛顿临床转化科学研究所，该研究所是华盛顿特区地区学术医疗中心的联盟。该计划将吸引来自四个机构的NIH资助的肺和睡眠研究人员：儿童国家医学中心、霍华德大学(历史上的一所黑人大学)、乔治敦大学和乔治华盛顿大学。该计划的管理和遗传学/基因组学的实验室培训将集中在国家儿童医学中心的遗传医学研究中心。该中心在遗传学/基因组学方面的培训、研究和技术创新方面享有盛誉。Eric Hoffman博士既是遗传医学研究中心的主任，也是拟议的K12遗传学/肺基因组学培训计划的项目主任。遗传学、基因组学和蛋白质组学方面的正式核心课程将在华中卫理公会大学、乔治华盛顿大学和北京大学教授。教学研究课程将利用为支持CNMC和其他三家参与机构的K奖项而开发的教育项目。潜在的受训者将从所有四所参与机构中挑选出来，并与最符合他们的兴趣和职业轨迹的导师和项目保持一致。拟议的K12领导和二级导师的研究优势集中在哮喘、肺重塑、急性肺损伤、睡眠障碍、儿科肺部健康、肺部疾病的健康差异，以及遗传学、基因组学和蛋白质组学。将在研究项目中使用的遗传学/基因组学的技术优势包括单核苷酸多态(SNP)关联研究、信使核糖核酸和蛋白质组谱分析以及生物信息学。我们建议每年培训三名基础和/或临床翻译研究员，在拟议的5年内，总共有6-8名学员从严格的计划中毕业。 (摘要结束)

DESCRIPTION (provided by applicant): We propose a K12 training program in genetics/genomics of lung disease for the Washington DC area. The proposed K12 will be integrated into the recently created Washington Institute of Clinical Translational Science, a consortium of Washington DC area academic medical centers. The Program will draw upon NIH funded lung and sleep researchers from four institutions: Children's National Medical Center, Howard University (a historically black university), Georgetown University, and George Washington University. The administration of the Program and laboratory training in genetics/genomics will be centered in the Research Center for Genetic Medicine in Children's National Medical Center. The Center is well-recognized for training, research, and technological innovations in genetics/genomics. Dr. Eric Hoffman serves as both the Director of the Research Center for Genetic Medicine and as Program Director for the proposed K12 genetics/genomics of lung training program. Formal Core Courses in genetics, genomics and proteomics will be taught at CNMC, GWU, and GU. The Didactic Research Curriculum will utilize the educational programs that have been developed to support K awards at CNMC and the other three participating institutions. Potential trainees will be drawn from all four participating institutions and aligned with mentors and projects that best match their interests and career trajectory. Research strengths of the proposed K12 lead and secondary mentors focus on asthma, lung remodeling, acute lung injury, sleep disorders, pediatric lung health, and health disparities in lung disease, as well as on genetics, genomics and proteomics. Technical strengths in genetics/genomics that will be used in research projects include single nucleotide polymorphism (SNP) association studies, mRNA and proteomic profiling, and bioinformatics. We propose to train three Basic and/or Clinical Translational Fellows per year, for a total of 6-8 trainees graduating from the rigorous program over the proposed 5 yr period. (End of Abstract)