AN EXERCISE INTERVENTION IN INSULIN-RESISTANT MINORITY ADOLESCENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 儿童2型糖尿病发病率的增加与肥胖患病率的增加相平行。肥胖通常伴有胰岛素抵抗和高胰岛素血症，其先于2型糖尿病并在2型糖尿病的发展中起主要作用。这种现象可能与美国青少年，特别是女孩，在青春期早期身体活动减少有关，这解释了青少年2型糖尿病主要在青春期和青春期后发病。虽然有规律的身体活动已被建议在高危儿童和青少年中减轻肥胖和预防2型糖尿病，但运动训练诱导的2型糖尿病风险因素改善的幅度最近才在成人中进行了研究，而没有在儿科人群中进行研究。本研究的目的是：1）确定运动对胰岛素抵抗的非洲裔美国人和西班牙裔青少年胰岛素敏感性的影响; 2）确定运动对胰岛素抵抗的非洲裔美国人和西班牙裔青少年纤溶标志物的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increased incidence of pediatric type 2 diabetes parallels increased prevalence of obesity. Obesity is commonly accompanied by insulin resistance and hyperinsulinemia, which precedes and plays a major role in the development of type 2 diabetes. This phenomenon may be related with the fact that American adolescents, especially girls, are now becoming less physically active in early puberty, explaining the largely pubertal and post-pubertal onset of type 2 diabetes in adolescents. Although regular physical activity has been suggested to attenuate obesity and prevent type 2 diabetes in high-risk children and adolescents, the magnitude of exercise training-induced improvement in the risk factors for type 2 diabetes has been only recently studied in adults and not studied in pediatric populations. The objectives of this study are: 1) to determine the effects of exercise on insulin sensitivity in insulin-resistant African-American and Hispanic adolescents and 2) to determine the effects of exercise on fibrinolytic markers in insulin-resistant African-American and Hispanic adolescents.