Genetics and Genomic Approaches to Lung Diseases and Disorders in Washington, DC

我们建议在华盛顿DC地区的遗传学/基因组学肺部疾病的K12培训计划。拟议中的K12将被整合到最近成立的华盛顿临床转化科学研究所，这是华盛顿地区学术医疗中心的联盟。该计划将利用美国国立卫生研究院资助的肺和睡眠研究人员从四个机构：儿童国家医疗中心，霍华德， 大学（一所历史上的黑人大学）、乔治敦大学和乔治华盛顿大学。该计划的管理和遗传学/基因组学的实验室培训将集中在儿童国家医学中心的遗传医学研究中心。该中心在遗传学/基因组学的培训，研究和技术创新方面得到了广泛认可。埃里克霍夫曼博士既担任 遗传医学研究中心主任，并担任拟议的K12遗传学/肺部基因组学培训计划的项目主任。在遗传学，基因组学和蛋白质组学的正式核心课程将在CNMC，GWU和GU教授。教学研究课程将利用已开发的教育计划，以支持CNMC和其他三个参与机构的K奖。潜在的学员将从所有四个参与机构中挑选，并与最符合其兴趣和职业轨迹的导师和项目保持一致。拟议的K12领导和二级导师的研究优势集中在哮喘，肺重塑，急性肺损伤，睡眠障碍，儿科肺部健康和肺部疾病的健康差异，以及遗传学，基因组学和蛋白质组学。 将用于研究项目的遗传学/基因组学的技术优势包括单核苷酸多态性（SNP）关联研究，mRNA和蛋白质组学分析以及生物信息学。我们建议每年培训三名基础和/或临床翻译研究员，总共有6-8名学员从 在拟议的5年期间实施严格的方案。

We propose a K12 training program in genetics/genomics of lung disease for the Washington DC area. The proposed K12 will be integrated into the recently created Washington Institute of Clinical Translational Science, a consortium of Washington DC area academic medical centers. The Program will draw upon NIH-funded lung and sleep researchers from four institutions: Children's National Medical Center, Howard University (a historically black university), Georgetown University, and George Washington University. The administration of the Program and laboratory training in genetics/genomics will be centered in the Research Center for Genetic Medicine in Children's National Medical Center. The Center is well-recognized for training, research, and technological innovations in genetics/genomics. Dr. Eric Hoffman serves as both the Director of the Research Center for Genetic Medicine and as Program Director for the proposed K12 genetics/genomics of lung training program. Formal Core Courses in genetics, genomics and proteomics will be taught at CNMC, GWU, and GU. The Didactic Research Curriculum will utilize the educational programs that have been developed to support K awards at CNMC and the other three participating institutions. Potential trainees will be drawn from all four participating institutions and aligned with mentors and projects that best match their interests and career trajectory. Research strengths of the proposed K12 lead and secondary mentors focus on asthma, lung remodeling, acute lung injury, sleep disorders, pediatric lung health, and health disparities in lung disease, as well as on genetics, genomics and proteomics. Technical strengths in genetics/genomics that will be used in research projects include single nucleotide polymorphism (SNP) association studies, mRNA and proteomic profiling, and bioinformatics. We propose to train three Basic and/or Clinical Translational Fellows per year, for a total of 6-8 trainees graduating from the rigorous program over the proposed 5 yr period.