AN EXERCISE INTERVENTION IN INSULIN-RESISTANT MINORITY ADOLESCENTS

对胰岛素抵抗的少数青少年的运动干预

• 批准号: 8167332
• 负责人: ERIC P. HOFFMAN
• 金额: $ 1.17万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167332
• 关键词: Adolescent; Adult; African American; American; Attenuated; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Development; Exercise; Funding; Grant; Hispanics; Hyperinsulinism; Incidence; Institution; Insulin Resistance; Intervention; Minority; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Physical activity; Play; Population; Prevalence; Puberty; Research; Research Personnel; Resources; Risk Factors; Role; Source; Training; United States National Institutes of Health; girls; high risk; insulin sensitivity; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increased incidence of pediatric type 2 diabetes parallels increased prevalence of obesity. Obesity is commonly accompanied by insulin resistance and hyperinsulinemia, which precedes and plays a major role in the development of type 2 diabetes. This phenomenon may be related with the fact that American adolescents, especially girls, are now becoming less physically active in early puberty, explaining the largely pubertal and post-pubertal onset of type 2 diabetes in adolescents. Although regular physical activity has been suggested to attenuate obesity and prevent type 2 diabetes in high-risk children and adolescents, the magnitude of exercise training-induced improvement in the risk factors for type 2 diabetes has been only recently studied in adults and not studied in pediatric populations. The objectives of this study are: 1) to determine the effects of exercise on insulin sensitivity in insulin-resistant African-American and Hispanic adolescents and 2) to determine the effects of exercise on fibrinolytic markers in insulin-resistant African-American and Hispanic adolescents.

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