Mesenchymal Stem Cell maintenance and recruitment during skeletal repair are dependent on EphB-ephrinB signalling

骨骼修复过程中间充质干细胞的维持和招募依赖于 EphB-ephrinB 信号传导

• 批准号: nhmrc : 1023390
• 负责人: Prof Andrew Zannettino
• 金额: $ 40.8万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mesenchymal-stem-cell-ephrinb-signalling/110271
• 关键词: Mesenchymal; Stem; Cell; maintenance; recruitment

There is currently a steady increase in surgical intervention and rehabilitation therapy for bone related fractures due to trauma or osteoporosis as a consequence of an aging population. Bone regeneration involves the coordinated participation of skeletal precursor cells, blood vessels and immune cells recruited from the surrounding tissues. This proposal examines the mechanisms mediating the maintenance and recruitment of skeletal precursor cells to sites of bone damage.

目前，由于人口老龄化，由于创伤或骨质疏松症导致的骨相关骨折的手术干预和康复治疗稳步增加。骨再生涉及骨骼前体细胞、血管和从周围组织募集的免疫细胞的协调参与。该提案探讨了介导骨骼前体细胞维持和募集到骨损伤部位的机制。