Twist-1 inhibits MSC osteoblast differentiation during osteoporosis via direct regulation of the Wnt signalling pathway

Twist-1 通过直接调节 Wnt 信号通路抑制骨质疏松期间 MSC 成骨细胞分化

• 批准号: nhmrc : 1046053
• 负责人: Prof Andrew Zannettino
• 金额: $ 32.19万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/twist-1-inhibits-signalling-pathway/111815
• 关键词: Twist; inhibits; MSC; osteoblast; differentiation

There is a predicted dramatic increase in the number of orthopaedic related problems that require surgical intervention and rehabilitation therapy in the coming decade associated with higher incidences of bone diseases as a consequence of an aging population. This proposal seeks to determine whether the transcription factor, Twist-1 plays a central role in regulating the growth and differentiation of skeletal progenitors during bone loss following the onset of osteoporosis.

预计在未来十年内，需要手术干预和康复治疗的骨科相关问题的数量将急剧增加，这与人口老龄化导致的骨疾病发病率升高有关。该提案旨在确定转录因子Twist-1是否在骨质疏松症发作后骨丢失期间调节骨骼祖细胞的生长和分化中起核心作用。