Relationships Between Human Osteoblasts and Haemopoietic Cells in Bone Remodelling

人成骨细胞与造血细胞在骨重塑中的关系

基本信息

  • 批准号:
    nhmrc : 299031
  • 负责人:
  • 金额:
    $ 29.1万
  • 依托单位:
  • 依托单位国家:
    澳大利亚
  • 项目类别:
    NHMRC Project Grants
  • 财政年份:
    2004
  • 资助国家:
    澳大利亚
  • 起止时间:
    2004-01-01 至 2006-12-31
  • 项目状态:
    已结题

项目摘要

Bone diseases, such as osteoporosis and osteoarthritis, currently afflict more than 4 million Australians. These diseases are characterised by abnormal bone remodelling, which can result in a net loss of bone (for example, in osteoporosis) or abnormal bone structure (for example, in osteoarthritis). We are seeking to better understand the factors that regulate bone remodelling, and particularly the cells involved in this process. Physiological bone remodelling results from the intimate collaboration between osteoblasts and osteoclasts. Osteoblasts stimulate the formation of osteoclasts and also produce new bone at resporption sites. However, the way that the same type of cell can perform both these tasks, is not clear. Our studies are designed to increase our understanding of the development of human osteoblasts and of the factors that cause them to be sequentially pro-osteoclastic and then pro-osteogenic. We believe that an important factor in this process is vitamin D and we will test the hypothesis that this molecule is produced in bone and acts locally to regulate bone turnover.
骨病,如骨质疏松症和骨关节炎,目前折磨着400多万澳大利亚人。这些疾病的特征是异常的骨重塑,这可能导致骨的净损失(例如骨质疏松症)或异常的骨结构(例如骨关节炎)。我们正在寻求更好地了解调节骨重塑的因素,特别是参与这一过程的细胞。生理性骨重塑是成骨细胞和破骨细胞密切合作的结果。成骨细胞刺激破骨细胞的形成,并在反应部位产生新骨。然而,同一类型的细胞能够同时完成这两项任务的方式尚不清楚。我们的研究旨在增加我们对人类成骨细胞发育的理解,以及导致它们依次具有破骨性和成骨性的因素。我们相信这个过程中的一个重要因素是维生素D,我们将测试这种分子是在骨骼中产生的,并在局部调节骨骼更新的假设。

项目成果

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Prof Andrew Zannettino其他文献

Prof Andrew Zannettino的其他文献

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{{ truncateString('Prof Andrew Zannettino', 18)}}的其他基金

Tyrosine kinase receptor c-ros-oncogene 1 mediates Twist-1 haploinsufficiency induced craniosynostosis in children: A novel therapeutic target
酪氨酸激酶受体c-ros-癌基因1介导Twist-1单倍体不足引起的儿童颅缝早闭:一个新的治疗靶点
  • 批准号:
    nhmrc : 1120989
  • 财政年份:
    2017
  • 资助金额:
    $ 29.1万
  • 项目类别:
    Project Grants
Tyrosine kinase receptor c-ros-oncogene 1 mediates Twist-1 haploinsufficiency induced craniosynostosis in children: A novel therapeutic target
酪氨酸激酶受体c-ros-癌基因1介导Twist-1单倍体不足引起的儿童颅缝早闭:一个新的治疗靶点
  • 批准号:
    nhmrc : GNT1120989
  • 财政年份:
    2017
  • 资助金额:
    $ 29.1万
  • 项目类别:
    Project Grants
Skeletal endocrine signalling in the regulation of glucose metabolism
骨骼内分泌信号在葡萄糖代谢调节中的作用
  • 批准号:
    DP160100454
  • 财政年份:
    2016
  • 资助金额:
    $ 29.1万
  • 项目类别:
    Discovery Projects
A genomic approach towards an understanding of clonal evolution and disease progression in multiple myeloma
了解多发性骨髓瘤克隆进化和疾病进展的基因组方法
  • 批准号:
    nhmrc : 1065314
  • 财政年份:
    2014
  • 资助金额:
    $ 29.1万
  • 项目类别:
    Project Grants
Twist-1 inhibits MSC osteoblast differentiation during osteoporosis via direct regulation of the Wnt signalling pathway
Twist-1 通过直接调节 Wnt 信号通路抑制骨质疏松期间 MSC 成骨细胞分化
  • 批准号:
    nhmrc : 1046053
  • 财政年份:
    2013
  • 资助金额:
    $ 29.1万
  • 项目类别:
    Project Grants
Mesenchymal Stem Cell maintenance and recruitment during skeletal repair are dependent on EphB-ephrinB signalling
骨骼修复过程中间充质干细胞的维持和招募依赖于 EphB-ephrinB 信号传导
  • 批准号:
    nhmrc : 1023390
  • 财政年份:
    2012
  • 资助金额:
    $ 29.1万
  • 项目类别:
    NHMRC Project Grants
Twist-1 Mediated Regulation of Multipotential Mesenchymal Stem Cell Self-Renewal and Cell Fate Determination
Twist-1 介导的多能间充质干细胞自我更新和细胞命运决定的调节
  • 批准号:
    nhmrc : 626910
  • 财政年份:
    2010
  • 资助金额:
    $ 29.1万
  • 项目类别:
    NHMRC Project Grants
The role of TWIST family basic Helix-Loop-Helix transcription Factors in Bone Cell Commitment, Function and Repair
TWIST 家族基本 Helix-Loop-Helix 转录因子在骨细胞承诺、功能和修复中的作用
  • 批准号:
    nhmrc : 453497
  • 财政年份:
    2007
  • 资助金额:
    $ 29.1万
  • 项目类别:
    NHMRC Project Grants
Molecular and cellular mechanisms of skeletal disease mediated by plasma cell dyscrasias
浆细胞恶液质介导的骨骼疾病的分子和细胞机制
  • 批准号:
    nhmrc : 298935
  • 财政年份:
    2004
  • 资助金额:
    $ 29.1万
  • 项目类别:
    NHMRC Project Grants
Human osteoclast formation
人破骨细胞形成
  • 批准号:
    nhmrc : 157984
  • 财政年份:
    2001
  • 资助金额:
    $ 29.1万
  • 项目类别:
    NHMRC Project Grants

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