A genomic approach towards an understanding of clonal evolution and disease progression in multiple myeloma

了解多发性骨髓瘤克隆进化和疾病进展的基因组方法

• 批准号: nhmrc : 1065314
• 负责人: Prof Andrew Zannettino
• 金额: $ 44.79万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomic-approach-an-multiple-myeloma/455160
• 关键词: genomic; approach; towards; understanding; clonal

Cancer development is associated with changes in the genetic composition of the cell. These changes involve the loss/gain of genetic material and/or changes in gene expression. Using sophisticated technology, we will define the changes in the genes that are associated with the transition from a benign to a malignant cancer state. We will examine this process in the blood cancer, multiple myeloma, in order to identify new treatment targets for this incurable disease.

癌症的发展与细胞基因组成的变化有关。这些变化涉及遗传物质的丧失/获得和/或基因表达的变化。使用尖端技术，我们将定义与从良性癌症状态向恶性癌症状态转变相关的基因变化。我们将在血癌、多发性骨髓瘤中研究这一过程，以确定这种不治之症的新治疗靶点。